| Project/Area Number |
20500373
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Kobe University |
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Principal Investigator |
ITO Takashi Kobe University, 大学院・医学研究科, 助手 (30135793)
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| Co-Investigator(Kenkyū-buntansha) |
SHIOMI Masashi 神戸大学, 大学院・医学研究科, 准教授 (50226106)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 育種学 / モデル動物 / 循環器・高血圧 / 糖尿病 / 動物 / メタボリックシンドローム / 内臓脂肪の蓄積 / 動脈硬化 / 高脂血症 / インスリン抵抗性 / 疾患モデル動物 / 血糖値 / 血清中性脂肪 |
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| Research Abstract |
In the present study, we have developed an animal model for metabolic syndrome by improving the WHHLMI rabbit, an animal model for spontaneous coronary atherosclerosis and myocardial infarction, and have analyzed influences of visceral fat accumulation on progression of atherosclerosis. To develop WHHLMI rabbits with metabolic syndrome, we carried out selective breeding using indices of serum levels of blood sugar and immunoreactive insulin. Metabolic syndrome of this rabbits was inherited from the parents to the offspring. Accumulation of visceral fat was increased with aging, and related to area of atherosclerotic lesions in the aorta. These results suggested that WHHLMI rabbits is a good animal model for metabolic syndrome.
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