Reconstruction of a genetic model rat of hypertension : Construction of double to four-fold congenic strains

• Project/Area Number: 20500374
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory animal science
• Research Institution: Shimane University
• Principal Investigator: CUI Zh Shimane University, 医学部, 助教 (50379690)
• Co-Investigator(Kenkyū-buntansha): NABIKA Toru 島根大学, 医学部, 教授 (50180534)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 疾患モデル / コンジェニックラット

Research Abstract

Reconstruction of a genetic model rat of hypertension : Construction of double to four-fold congenic strains

Research Products

• [Journal Article] A 1.8-Mbp fragment on chromosome 1 affects sympathetic response to stress : evaluation in reciprocal congenic strains between stroke-prone spontaneously hypertensive rat and Wistar-Kyoto rat. (2011)
  • Author(s): Xiao B, Harada Y, Kawakami K, Nabika T.
  • Journal Title: J Hypertens. 29(2) Pages: 257-265
• [Journal Article] Characterizing photothrombotic distal middle cerebral artery occlusion and YAG laser-induced reperfusion model in the Izumo strain of spontaneously hypertensive rats. (2011)
  • Author(s): Yao H, Nabika T.
  • Journal Title: Cell Mol Neurobiol. 31(1) Pages: 57-63
• [Journal Article] Blood pressure-independent factors determine the susceptibility to delayed neuronal death in the stroke-prone spontaneously hypertensive rats. (2010)
  • Author(s): Sakurai-Yamashita Y, Nabika T, Niwa M.
  • Journal Title: Cell Mol Neurobiol. 30(2) Pages: 283-287
• [Journal Article] Quantitative analysis of delayed neuronal death in the hippocampal subfields of SHRSP and SHR. (2009)
  • Author(s): Daisu M, Hatta T, Sakurai-Yamashita Y, Nabika T, Moritake K.
  • Journal Title: Cell Mol Neurobiol. 29(4) Pages: 557-262
• [Journal Article] Relation of blood pressure quantitative trait locus on rat chromosome 1 to hyperactivity of rostral ventrolateral medulla. (2009)
  • Author(s): Iigaya K, Kumagai H, Nabika T, Harada Y, Onimaru H, Oshima N, Takimoto C, Kamayachi T, Saruta T, Itoh H.
  • Journal Title: Hypertension. 53(1) Pages: 42-48
• [Journal Article] Genetic effects of blood pressure quantitative trait loci on hypertension-related organ damage : evaluation using multiple congenic strains. (2008)
  • Author(s): Ishikawa N, Harada Y, Maruyama R, Masuda J, Nabika T.
  • Journal Title: Hypertens Res. 31(9) Pages: 1773-1779
• [Journal Article] Sympathetic regulation of renal function in stroke-prone spontaneously hypertensive rats congenic for chromosome 1 blood pressure quantitative trait loci. (2008)
  • Author(s): Wang T, Takabatake T, Kobayashi Y, Nabika T.
  • Journal Title: Clin Exp Pharmacol Physiol. 35(11) Pages: 1365-1370
• [Journal Article] Sympathetic regulation of the renal functions in rats reciprocally congenic for chromosome 1 blood pressure quantitative trait locus. (2008)
  • Author(s): Wang T, Nabika T, Notsu Y, Takabatake T.
  • Journal Title: Hypertens Res. 31(3) Pages: 561-568
• [Presentation] Synergic effect of two QTLs on chromosome 1 and 18 accounts for the difference of stroke-susceptibility between SHR and SHRSP ; A study on a double-congenic strain. (2010)
  • Author(s): Cui ZH
  • Organizer: The XVIIIth International Workshop on Genetic Systems in the Rat.
  • Place of Presentation: 京都市
  • Year and Date: 2010-12-01
• [Presentation] SHRSP/IzmとSHR/Izmのコンジェニックラットによる脳卒中関連遺伝子の探索 (2010)
  • Author(s): 崔宗虎
  • Organizer: 第57回日本実験動物学会総会
  • Place of Presentation: 京都市
  • Year and Date: 2010-05-14
• [Presentation] Synergic effect of two QTLs on chromosome 1 and 18 accounts for the difference of stroke-susceptibility between SHR and SHRSP ; A study on a double-congenic strain. (2010)
  • Author(s): Cui ZH, Ozawa T, Gandolgor T-A, Xiao B, Kawakami K, Nabika T
  • Organizer: The X VIII th International Workshop on Genetic Systems in the Rat.
  • Place of Presentation: Kyoto, Japan.
• [Presentation] Effect of a 1.8-Mbp genomic fragment on chromosome 1 on sympathetic response to stressors : Evalution in reciprocal congenic strains between SHRSP and WKY. (2010)
  • Author(s): Xiao B,, Nabika T
  • Organizer: The X VIII th International Workshop on Genetic Systems in the Rat.
  • Place of Presentation: Kyoto, Japan.
• [Presentation] ラット第1染色体上の1.5Mbpの領域がSHRSPのストレス反応性に関与する (2010)
  • Author(s): 並河徹
  • Organizer: 第33回日本高血圧学会総会
  • Place of Presentation: 福岡
• [Presentation] Effect of a small genomic fragment on chromosome 1 on sympathetic response to stressors : Evaluation in reciprocal congenic strains between SHRSP and WKY. (2010)
  • Author(s): Xiao B,, Nabika T
  • Organizer: 6^<th> International ISP Congress and 14^<th> International SHR Sympsium.
  • Place of Presentation: Montreal, Canada.
• [Presentation] 心血管疾患のモデル動物:SHR and beyond. (2009)
  • Author(s): 並河徹
  • Organizer: 第32回日本高血圧学会総会
  • Place of Presentation: 大津市
• [Presentation] Circadian Variations in Systolic Blood Pressure, Heart Rate and Locomotor Activity in Congenic Rats. (2009)
  • Author(s): Kawamura H, Mitsubayashi H, Saito N, Nabika T
  • Organizer: 63^<rd> High Blood Pressure Research Conference 2009, InterContinental Chicago O'Hare Hotel
  • Place of Presentation: Chicago, IL
• [Presentation] SHRSP/Izmより良いコンジェニック・ラットの活動量と血圧の関係 (2009)
  • Author(s): 河村博, 三ツ林裕巳, 斎藤昇, 石山芳則, 並河徹
  • Organizer: 第45回高血圧関連疾患モデル学会学術総会
  • Place of Presentation: 東京都
• [Presentation] A small fragment on chromosome 1 controls urinary volume and norepinephrine excretion during cold stress. (2009)
  • Author(s): 肖冰, 並河徹
  • Organizer: 第45回高血圧関連疾患モデル学会学術総会
  • Place of Presentation: 東京都
• [Presentation] Circadian Variations in Arterial Pressure, Heart Rate and Locomotor Activity in Congenic Rats. (2009)
  • Author(s): Kawamura H, Mitsubayashi H, Saito N, Ishiyama Y, Kadota T, Nabika T
  • Organizer: Proceedings of the XXXVI International Congress of Physiological Sciences (IUPS2009) Function of Life: Elements and Integration
  • Place of Presentation: Kyoto, Japan
• [Presentation] 脳卒中関連QTL領域におけるmicrosatellite markerの多型検索 (2009)
  • Author(s): 崔宗虎, 平嶋司, 渡邊武, 並河徹
  • Organizer: 第56回日本実験動物学会総会
  • Place of Presentation: さいたま市
• [Presentation] Ship2遺伝子多型はラット耐糖能に関与しない. (2008)
  • Author(s): 肖 冰(崔5番目)
  • Organizer: 第44回高血圧関連疾患モデル学会学術総会
  • Place of Presentation: 出雲市
  • Year and Date: 2008-11-21
• [Presentation] Evaluation of the Sympathetic Response to the Cold Stress in a Series of Reciprocal Congenic Strains for the Chromosome-1 QTL. (2008)
  • Author(s): Nabika T (崔4番目)
  • Organizer: 13^<th> International SHR Symposium
  • Place of Presentation: プラハ
  • Year and Date: 2008-06-20
• [Presentation] Ship2遺伝子多型はラット耐糖能に関与しない (2008)
  • Author(s): 肖冰, 原田祐治, 川上浩平, 網野寛, 崔宗虎, 並河徹
  • Organizer: 第44回高血圧関連疾患モデル学会学術総会
  • Place of Presentation: 出雲市
• [Presentation] SHRSPにおける海馬CA1領域遅発性神経死の定量解析 (2008)
  • Author(s): 大洲光裕, 八田稔久, 山下康子, 並河徹, 森竹浩三
  • Organizer: 第44回高血圧関連疾患モデル学会学術総会
  • Place of Presentation: 出雲市
• [Presentation] メタボリックシンドロームモデルラット(SHR/cp)に対する給餌制限の効果 (2008)
  • Author(s): 川上浩平, 下崎俊介, 頓宮美樹, Sultana Razia, 土倉覚, 野村正人, 小林裕太, 並河徹, 山田高也
  • Organizer: 第44回高血圧関連疾患モデル学会学術総会
  • Place of Presentation: 出雲市
• [Presentation] 脳卒中感受性領域のコンジェニックラットにおける表現形質検索 (2008)
  • Author(s): 崔宗虎, 原田祐治, 並河徹
  • Organizer: 第44回高血圧関連疾患モデル学会学術総会
  • Place of Presentation: 出雲市
• [Presentation] コンジェニックラット(WKYpch1.0)における慢性的な環境ストレス負荷による血圧への影響 (2008)
  • Author(s): 仲本みのり, 大屋祐輔, 山里正演, 崎間敦, 並河徹, 瀧下修一
  • Organizer: 第31回日本高血圧学会総会
  • Place of Presentation: 札幌
• [Presentation] SHRSPをもとに作成したコンジェニックラットを用いた高血圧関連形質の解析 (2008)
  • Author(s): 並河徹
  • Organizer: 第31回日本高血圧学会総会
  • Place of Presentation: 札幌
• [Presentation] Evaluation of the Sympathetic Response to the Cold Stress in a Series of Reciprocal Congenic Strains for the Chromosome-1 QTL. (2008)
  • Author(s): Nabika T, Wang T, Xiao B, Cui ZH, Kawakami K, Notsu Y, Masuda J
  • Organizer: 13^<th> International SHR Symposium
  • Place of Presentation: Prague
• [Presentation] Rat Models?Tools for Understanding Genotype as an Interface between Environment and Phenotype. (2008)
  • Author(s): Nabika T
  • Organizer: 13^<th> International SHR Symposium
  • Place of Presentation: Prague
• [Presentation] SHRSPをもとに作成したコンジェニックラットを用いた高血圧関連形質の解析 (2008)
  • Author(s): 石川典由, 原田祐治, 益田順一, 並河徹
  • Organizer: 日本実験動物科学技術2008(第55回日本実験動物学会総会,第42回日本実験動物技術者協会総会:両総会の合同大会)
  • Place of Presentation: 仙台市
• [Remarks] ホームページ等