Development of a musculoskeletal computer model for laboratory mice

• Project/Area Number: 20500384
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory animal science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: OOTA SATOSHI The Institute of Physical and Chemical Research, 情報解析技術室, 専任研究員 (30391890)
• Co-Investigator(Kenkyū-buntansha): ATSUSHI Yoshiki 独立行政法人理化学研究所, 実験動物開発室, 室長 (40212310) ; KAZUHIRO Kawamura 筑波大学, 数理物質科学研究科, 准教授 (40204771)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 筋骨格モデル / 逆運動学 / 運動機能 / 進化的相同性 / モーションキャプチャ / 写像 / 機能解放学的情報 / 実験用マウス / 筋腱構造 / X線CTスキャン / 進化 / Musculoskeletal model / Mutant mouse / Inverse kinematics / 突然変異マウス / 骨格モデル / 歩行データ

Research Abstract

We developed a musculoskeletal computer model for laboratory mice, whose genetic backgrounds have been established. We employed the motion capture technology to establish a totally new framework for mouse motor function analyses with the musculoskeletal computer model. To develop a reliable musculoskeletal computer model for laboratory mice, we devised a new method to map information on a human musculoskeletal model onto a mouse skeletal model. Furthermore, we performed validation and improvement of the model by using 3-dimensional geometries of tendon tissues reconstructed from sliced data of a transgenic mouse.

Research Products

• [Journal Article] CT image segmentation using structural analysis. (2010)
  • Author(s): Hishida H., T.Michikawa, Y.Ohtake, H.Suzuki, S.Oota
  • Journal Title: Proceedings of the 6th international conference on Advances in visual computing.(Springer-Verlag, Las Vegas, NV, USA.) Pages: 39-48
  • Peer Reviewed
• [Journal Article] A new framework for studying the isochore evolution : estimation of the equilibrium GC content based on the temporal mutation rate model. (2010)
  • Author(s): Oota S., K.Kawamura, Y.Kawai, N.Saitou
  • Journal Title: Genome Biol Evol 2 Pages: 558-571
  • Peer Reviewed
• [Journal Article] Development of a coarse-grained skeletal model of laboratory mouse and its biomechanical applications. Reviewed electric materials. (2010)
  • Author(s): Oota S., A.Yoshiki, Y.Fujita, J.Humphries, K.Fukami-Kobayashi, Y.Obata, T.Rowe, Y.Nakamura
  • Journal Title: 1st International Conference on Applied Bionics and Biomechanics (ICABB-2010)(VENICE, ITALY.)
  • Peer Reviewed
• [Journal Article] Development of a coarse-grained skeletal model of laboratory mouse and its biomechanical applications (2010)
  • Author(s): Oota, S., A.Yoshiki, Y.Fujita, J.Humphries, K.Fukami-Kobayashi, Y.Obata, T.Rowe, Y.Nakamura
  • Journal Title: Proceeding in 1st International Conference on Applied Bionics and Biomechanics (ICABB-2010) Volume: (Electric proceeding)
  • Peer Reviewed
• [Journal Article] A new framework for studying the isochore evolution : estimation of the equilibrium GC content based on the temporal mutation rato model (2010)
  • Author(s): Oota, S., K.Kawamura, Y.Kawai, N.Saitou
  • Journal Title: Genome Biol Evol Volume: 2 Pages: 558-571
  • Peer Reviewed
• [Journal Article] CT image segmentation using structural analysis (2010)
  • Author(s): Hishida, H., T.Michikawa, Y.Ohtake, H.Suzuki, S.Oota
  • Journal Title: Proceedings of the 6th international conference on Advances in visual computing Volume: 3 Pages: 39-48
  • Peer Reviewed
• [Journal Article] Unique inbred strain MSM/Ms established from the Japanese wild mouse. (2009)
  • Author(s): Moriwaki K., N.Miyashita, A.Mita, H.Gotoh, K.Tsuchiya, H.Kato, K.Mekada, CNoro, S. Oota, A.Yoshiki, Y.Obata, H.Yonekawa, T.Shiroishi
  • Journal Title: Exp Anim 58 Pages: 123-134
  • NAID: 10024838237
  • Peer Reviewed
• [Journal Article] Four-dimensional quantitative analysis of the gait of mutant mice using coarse-grained motion capture (2009)
  • Author(s): Oota S., K.Mekada, Y.Fujita, J.Humphries, K.Fukami-Kobayashi, Y.Obata, R.T., Y.A.
  • Journal Title: EMBS '09. 31st Annual International Conference of the IEEE. Pages: 5227-5230
  • Peer Reviewed
• [Journal Article] Four-dimensional quantitative analysis of the gait of mutant mice using coarse-grained motion capture (2009)
  • Author(s): Oota S, Mekada K, Fujita Y, Humphries J, Fukami-Kobayashi K, Obata Y, Rowe T, Yoshiki A.
  • Journal Title: Conf Proc IEEE Eng Med Biol Soc. 1 Pages: 5227-5230
  • Peer Reviewed
• [Presentation] CT Image Segmentation using Structural Analysis. (2010)
  • Author(s): HISHIDA H., T.MICHIKAWA, Y.OHTAKE, H.SUZUKI, S.OOTA
  • Organizer: 6th International Symposium on Visual Computing (ISVC06)
  • Place of Presentation: Las Vegas, Nevada, USA
  • Year and Date: 2010-11-30
• [Presentation] CT Image Segmentation using Structural Analysis. (2010)
  • Author(s): HISHIDA, H.
  • Organizer: 6th International Symposium on Visual Computing (ISVC06)
  • Place of Presentation: Las Vegas
  • Year and Date: 2010-11-30
• [Presentation] Development of a coarse-grained skeletal model of laboratory mouse and its applications. (2010)
  • Author(s): Oota S., A.Yoshiki, Y.Fujita, J.Humphries, K.Fukami-Kobayashi, Y.Obata, T.Rowe, Y.Nakamura
  • Organizer: 1st International Conference on Applied Bionics and Biomechanics
  • Place of Presentation: Venice, Italy
  • Year and Date: 2010-10-15
• [Presentation] Development of a coarse-grained skeletal model of laboratory mouse and its applications (2010)
  • Author(s): Oota, S.
  • Organizer: 1st International Conference on Applied Bionics and Biomechanics
  • Place of Presentation: Venice
  • Year and Date: 2010-10-15
• [Presentation] Analysis on mutant specific gait patterns of mutant mice with inverse dynamics. (2010)
  • Author(s): Oota S., Y.Nakamura, Y.Obata, A.Yoshiki
  • Organizer: Neuro 2010
  • Place of Presentation: Nagoya
  • Year and Date: 2010-09-04
• [Presentation] Analysis on mutant specific gait patterns of mutant mice with inverse dynamics (2010)
  • Author(s): Oota, S.
  • Organizer: Neuro 2010
  • Place of Presentation: Nagoya
  • Year and Date: 2010-09-04
• [Presentation] (2010)
  • Author(s): Oota S., A.Yoshiki, H.Yokota, Y.Obata, Y.Nakamura, R.Himeno
  • Organizer: Of Mice and Men : Biomechanical Modeling as a Tool to Translate Bone Biology Research into Clinical Practice 6th World Congress of Biomechanics (WCB 2010)
  • Place of Presentation: Singapore
  • Year and Date: 2010-08-05
• [Presentation] Of Mice and Men : Biomechanical Modeling as a Tool to Translate Bone Biology Research into Clinical Practice (2010)
  • Author(s): Oota, S.
  • Organizer: 6th World Congress of Biomechanics (WCB 2010)
  • Place of Presentation: Singapore
  • Year and Date: 2010-08-05
• [Presentation] A new approach to analyze mutant specific gait patterns of mutant mice (2009)
  • Author(s): Oota S
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-09-18
• [Presentation] Four-dimensional quantitative analysis of the gait of mutant mice using coarse-grained motion capture (2009)
  • Author(s): Oota S
  • Organizer: 31^<st> Annual International Conference of the IEEE Engineering in Medicine and Biology Sciety
  • Place of Presentation: Hilton Minneapolis, Minnesota, USA
  • Year and Date: 2009-09-05
• [Presentation] 定量的な歩行パターン解析のための突然変異マウス筋骨格系モデルの構築 (2008)
  • Author(s): 太田聡史
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-09
• [Remarks] ホームページ等
  • URL: http://web.me.com/satoshi.oota/M.T.R./Home.html
• [Remarks]
  • URL: http://www.youtube.com/watch?v=_tPUfHKLquE
• [Remarks]
  • URL: http://web.me.com/satoshi.oota/Mouse_motor_functions/Objectives.html
• [Remarks]
  • URL: http://www.brc.riken.go.jp/lab/animal/mailnews/nm200910_02e.html