| Project/Area Number |
20500384
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
OOTA SATOSHI The Institute of Physical and Chemical Research, 情報解析技術室, 専任研究員 (30391890)
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| Co-Investigator(Kenkyū-buntansha) |
ATSUSHI Yoshiki 独立行政法人理化学研究所, 実験動物開発室, 室長 (40212310)
KAZUHIRO Kawamura 筑波大学, 数理物質科学研究科, 准教授 (40204771)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 筋骨格モデル / 逆運動学 / 運動機能 / 進化的相同性 / モーションキャプチャ / 写像 / 機能解放学的情報 / 実験用マウス / 筋腱構造 / X線CTスキャン / 進化 / Musculoskeletal model / Mutant mouse / Inverse kinematics / 突然変異マウス / 骨格モデル / 歩行データ |
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| Research Abstract |
We developed a musculoskeletal computer model for laboratory mice, whose genetic backgrounds have been established. We employed the motion capture technology to establish a totally new framework for mouse motor function analyses with the musculoskeletal computer model. To develop a reliable musculoskeletal computer model for laboratory mice, we devised a new method to map information on a human musculoskeletal model onto a mouse skeletal model. Furthermore, we performed validation and improvement of the model by using 3-dimensional geometries of tendon tissues reconstructed from sliced data of a transgenic mouse.
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