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Development and Assessment of tomosynthesis reconstruction algorithm based on refraction contrast

Research Project

Project/Area Number 20500385
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionYamagata University

Principal Investigator

YUASA Tetsuya  Yamagata University, 大学院・理工学研究科, 教授 (30240146)

Co-Investigator(Renkei-kenkyūsha) ANDO Masami  東京理科大学, 教授 (30013501)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords放射光X線 / 屈折コントラスト / トモシンセシス / 乳がん / 早期診断 / 屈折コントラス
Research Abstract

A novel tomosynthesis imaging system for soft tissues using Laue-case analyzer is described. Since the imaging system obtains angular deviation by refraction from the projections simultaneously acquired in forwardly diffracted and diffracted directions, the measurement time as well as the radiation dose required decreases by one half compared to the conventional diffraction enhanced imaging (DEI) method. In addition, the proposed reconstruction algorithm derived from the quantitative relationship in measurement process produces images in no way inferior to refraction-contrast CT images from the viewpoint of morphological imaging in spite of one tenth the radiation dose of refraction-contrast CT imaging. We ex vivo imaged a lung tissue sample excised from a human using the system constructed at the vertical wiggler beamline PF-BL14C in KEK to demonstrate the efficacy of the proposed imaging protocol.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (38 results)

All 2011 2010 2009 2008 Other

All Journal Article (28 results) (of which Peer Reviewed: 28 results) Presentation (10 results)

  • [Journal Article] Convolution reconstruction algorithm for refraction-contrast computed tomography using a Laue-case analyzer for dark field imaging2011

    • Author(s)
      N.Sunaguchi, T.Yuasa, Q.Huo, M.Ando
    • Journal Title

      Optics Letters Vol.36, No.3

      Pages: 391-393

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Convolution reconstruction algorithm for refraction-contrast computed tomography using a Laue-case analyzer for dark field imaging2011

    • Author(s)
      N.Sunaguchi, T.Yuasa, Q.Huo, M.Ando
    • Journal Title

      Optics Letters

      Volume: 36 Pages: 391-393

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] X-ray refraction-contrast computed tomography images using dark field imaging optics2010

    • Author(s)
      N.Sunaguchi, T.Yuasa, Q.Huo, S.Ichihara, M.Ando
    • Journal Title

      Appl.Phys.Lett. Vol.97

      Pages: 153701-153701

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Use of synchrotron-based diffraction-enhanced imaging for visualization of soft tissues in invertebrates2010

    • Author(s)
      D.V.Rao, M.Swapna, R.Cesareo, A.Brunetti, Z.Zhong, T.Akatsuka, T.Yuasa, T.Takeda, G.E.Gigante
    • Journal Title

      Applied Radiation and Isotopes Vol.68, Iss.9

      Pages: 1987-1993

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 屈折コントラストによるCT 画像形成理論2010

    • Author(s)
      砂口尚輝,湯浅哲也
    • Journal Title

      Medical Imaging Technology Vol.28, No.2

      Pages: 96-101

    • NAID

      10026248442

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] X-ray refraction-contrast computed tomography images using dark field imaging optics2010

    • Author(s)
      N.Sunaguchi, T.Yuasa, Q.Huo, S.Ichihara, M.Ando
    • Journal Title

      Applied Physics Letters

      Volume: 97 Pages: 153701-153701

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of synchrotron-based diffraction-enhanced imaging for visualization of soft tissues in invertebrates2010

    • Author(s)
      D.V.Rao, M.Swapna, R.Cesareo, A.Brunetti, Z.Zhong, T.Akatsuka, T.Yuasa, T.Takeda, G.E.Gigante
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 68 Pages: 1987-1993

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 屈折コントラストによるCT画像形成理論2010

    • Author(s)
      砂口尚輝, 湯浅哲也
    • Journal Title

      Medical Imaging Technology 28

      Pages: 96-101

    • NAID

      10026248442

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Depth-resolving THz imaging with tomosynthesis2009

    • Author(s)
      N.Sunaguchi, Y.Sasaki, N.Maikusa, M.Kawai, T.Yuasa, C.Otani
    • Journal Title

      Optics Express Vol.17, No.12

      Pages: 9558-9570

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of the distribution of elements in snail shell with the use of synchrotron-based, micro-beam X-ray fluorescence spectrometry2009

    • Author(s)
      D.V.Rao, M.Swapna, R.Cesareo, A.Brunetti, T.Akatsuka, T.Yuasa, T.Takeda, G.Tromba, G.E.Gigante
    • Journal Title

      Journal of Trace Elements in Medicine and Biology Vol.23, Iss.4,

      Pages: 251-257

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] First experimental result with fluorescent x-ray CT based on sheet-beam geometory2009

    • Author(s)
      Q.Huo, H.Sato, T.Yuasa, T.Akatsuka, T.Takeda, J.Wu, Thet-Thet-Lwin, K.Hyodo
    • Journal Title

      X-Ray Spectrometry Vol.38, Iss.5

      Pages: 439-445

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synchrotron-induced X-ray fluorescence from rat bone and lumber vertebra of different age groups2009

    • Author(s)
      D.V.Rao, M.Swapna, R.Cesareo, A.Brunetti, T.Akatsuka, T.Yuasa, T.Takeda, G.Tromba, G.E.Gigante
    • Journal Title

      Nuclear Instruments and Methods in Physics Research B Vol.267, Iss.3

      Pages: 502-505

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] X-ray phase-contrast microtomography for visualizing renal microstructures of hamsters2009

    • Author(s)
      J.Wu, T.Takeda, Thet-Thet-Lwin, A.Momose, N.Sunaguchi, T.Fukami, T.Yuasa, T.Akatsuka
    • Journal Title

      Kidney International Vol.75, Iss.9

      Pages: 945-951

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Depth-resolving THz imaging with tomosynthesis2009

    • Author(s)
      N.Sunaguchi, Y.Sasaki, N.Maikusa, M.Kawai, T.Yuasa, C.Otani
    • Journal Title

      Optics Express 17

      Pages: 9558-9570

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of the distribution of elements in snail shell with the use of synchrotron-based, micro-beam X-ray fluorescence spectrometry2009

    • Author(s)
      D.V.Rao, M.Swapna, R.Cesareo, A.Brunetti, T.Akatsuka, T.Yuasa, T.Takeda, G.Tromba, G.E.Gigante
    • Journal Title

      Journal of Trace Elements in Medicine and Biology 23

      Pages: 251-257

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synchrotron-induced X-ray fluorescence from rat bone and lumber vertebra of different age groups2009

    • Author(s)
      D. V. Rao, M. Swapna, R. Cesareo, A. Brunetti, T. Akatsuka, T. Yuasa T. Takeda, G.. Tromba and G. E. Giaante
    • Journal Title

      NIM B 267

      Pages: 502-505

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] X-ray phase-contrast microtomography for visualizing renal microstructures ohamsters2009

    • Author(s)
      J. Wu, T. Takeda, Thet-Thet-Lwin, A. Momose, N. Sunaguchi, T. Fukami, T. Yuasa, T. Akatsuka
    • Journal Title

      Kidney International 75

      Pages: 945-951

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Refraction-based 2D, 2.5D and 3D medical imaging : Stepping forward to a clinical trial2008

    • Author(s)
      M.Ando, H.Bando, T.Endo, S.Ichihara, E.Hashimoto, K.Hyodo, T.Kunisada, G.Li, A.Maksimenko, K.Mori, D.Shimao, H.Sugiyama, T.Yuasa, E.Ueno
    • Journal Title

      European Journal of Radiology Vol.68S

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sheet-beam geometry for in vivo fluorescent x-ray computed tomography : proof-of-concept experiment in molecular imaging2008

    • Author(s)
      Q.Huo, T.Yuasa, T.Akatsuka, T.Takeda, J.Wu, Thet-Thet-Lwin, K.Hyodo, F.A.Dilmanian
    • Journal Title

      Optics Letters Vol.33, Iss.21

      Pages: 2494-2496

    • NAID

      120007138460

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of age-dependent cardiomyopathic model hamster obtained by fluorescent X-ray computed tomography using I127-IMP2008

    • Author(s)
      Thet-Thet-Lwin, T.Takeda, J.Wu, Q.Huo, T.Yuasa, K.Hyodo, T.Akatsuka
    • Journal Title

      Journal of Synchrotron Radiation Vol.15, Part 5

      Pages: 528-531

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Highly sensitive detection of the soft tissues based on refraction contrast by in-plane diffraction-enhanced imaging CT2008

    • Author(s)
      T.Yuasa, E.Hashimoto, A.Maksimenko, H.Sugiyama, Y.Arai, D.Shimao, S.Ichihara, M.Ando
    • Journal Title

      Nuclear Instruments and Methods in Physics Research A Vol.591

      Pages: 546-557

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 3-D Reconstruction of High-Grade Ductal Carcinoma In Situ of the Breast with Casting Type Calcifications using Refraction-Based X-Ray CT2008

    • Author(s)
      S.Ichihara, M.Ando, E.Hashimoto, A.Maksimenko, H.Sugiyama, C.Ohbayashi, T.Yuasa, K.Yamasaki, Y.Arai, K.Mori, T.Endo
    • Journal Title

      Virchows Archiv Vol.452, No.1

      Pages: 41-47

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Refraction-based 2D, 2.5D and 3D medical imaging : Stepping forward to a clinical trial2008

    • Author(s)
      M. Ando, H. Bando, T. Endo, S. I chihara, E. Hashimoto, K. Hyodo, T. Kunisada, G. Li, A. Maksimenko, K. Mori, D. Shimao, H. Sugiyam a, T. Yuasa, and E. Ueno
    • Journal Title

      uropean Journal of Radiology 68S

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sheet-beam geometry for in vivo fluorescent x-ray computed tomography : proof-of-concept experiment in molecular imaging2008

    • Author(s)
      Q. Huo, T. Yuasa, T. Akatsuka, T. Takeda, J. Wu, Thet-Thet-Lwin, K. Hyodo, F.A. Dilmanian
    • Journal Title

      Optics Letters 33

      Pages: 2494-2496

    • NAID

      120007138460

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of age-dependent cardiomyopathic model hamster obtained by flu orescent X-ray computed tomography using 1127-IMP2008

    • Author(s)
      Thet-The-Lwin, T. Takeda, J. Wu, Q. Huo, T. Yuasa, K. Hyodo, and T. Akatsuka
    • Journal Title

      Journal of Synchrotron Radiation 15

      Pages: 528-531

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly sensitive detection of the soft tissues based on refraction contrast by in-plane diffraction-enhanced imaging CT2008

    • Author(s)
      T. Yuasa, E. Hashimoto, A. Maksi menko, H. Sugiyama, Y. Arai, D. Shimao. S. Ichihara, and M. Ando
    • Journal Title

      NIM A 591

      Pages: 546-557

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3-D Reconstruction of High-Grade Ductal Carcinoma In Situ of the Breast with Casting Type Calcifications using Refraction-based X-Ray CT2008

    • Author(s)
      S. Ichihara, M. Ando, E. Hashimoto, A. Maksimenko, H. Sugiyama, C. Ohbayashi, T. Yuasa, K. Yamasaki, Y. Arai, K. Mori, and T. Endo
    • Journal Title

      Virchows Archiv 452

      Pages: 41-47

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] First experimental result with fluorescent x-Ray CT based on sheet-beam geometory

    • Author(s)
      Q. Huo, H. Sato, T. Yuasa, T. Aka tsuka, T. Takeda, J. Wu, Thet-Thet-Lwin, K. Hyodo
    • Journal Title

      X-Ray Spectrometry (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Reconstruction Algorithm of Refraction-Based Computed Tomography from Viewpoint of X-Ray Optics2011

    • Author(s)
      Tetsuya Yuasa
    • Organizer
      International Forum on Medical Imaging in Asia 2011
    • Place of Presentation
      Naha, Japan.
    • Year and Date
      2011-01-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Reconstruction Algorithm of Refraction-Based Computed Tomography from Viewpoint of X-Ray Optics2011

    • Author(s)
      湯浅哲也
    • Organizer
      International Forum on Medical Imaging in Asia 2011
    • Place of Presentation
      那覇てんぶす館(招待講演)
    • Year and Date
      2011-01-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 屈折コントラストX線CT再構成理論2010

    • Author(s)
      湯浅哲也
    • Organizer
      第27回センシングフォーラム
    • Place of Presentation
      群馬大学
    • Year and Date
      2010-09-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 世界に先駆けた屈折型CT技術開発と今後2010

    • Author(s)
      湯浅哲也
    • Organizer
      2010 年秋季第71回応用物理学会学術講演会
    • Place of Presentation
      長崎
    • Year and Date
      2010-09-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 世界に先駆けた屈折型CT技術開発と今後2010

    • Author(s)
      湯浅哲也
    • Organizer
      2010年秋季第71回応用物理学会学術講演会
    • Place of Presentation
      長崎大学(招待講演)
    • Year and Date
      2010-09-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 頭部MRI画像における形態の加齢変化2010

    • Author(s)
      二瓶光代, 足澤あや香, 田中美香, 深見忠典, 湯浅哲也, 呉勁, 川崎敬一, 石渡喜一, 石井賢二
    • Organizer
      電子情報通信学会MI研究会
    • Place of Presentation
      那覇市ぶんかテンブス館
    • Year and Date
      2010-01-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 放射線蛍光X線CTの解析的画像再構成アルゴリズムの開発2010

    • Author(s)
      中村俊輔, 霍慶凱, 湯浅哲也, 赤塚孝雄, 武田徹, 兵藤一行
    • Organizer
      電子情報通信学会MI研究会
    • Place of Presentation
      那覇市ぶんかテンブス館
    • Year and Date
      2010-01-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高コントラスト超音波血流イメージングに向けたサブハーモニックとセカンドハーモニック成分の融合手法2010

    • Author(s)
      新井博文, 舞草伯秀, 深見忠典, 湯浅哲也, 田村安孝, 赤塚孝雄
    • Organizer
      電子情報通信学会MI研究会
    • Place of Presentation
      那覇市ぶんかテンブス館
    • Year and Date
      2010-01-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] THz Tomography in digital tomosynthesis2009

    • Author(s)
      N.Sunaguchi, 舞草伯秀, M.Kawai, 湯浅哲也, Y.Sasaki, C.Otani
    • Organizer
      International Workshop on Teraherz Technology
    • Place of Presentation
      Osaka Univ.
    • Year and Date
      2009-12-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fluorescent X-Ray Computed Tomography towards Molecular Imaging : Proot-of-Concept Experiment2008

    • Author(s)
      T. Yuasa, Q. Huo, T. Akatsuka, K. Hyodo, and F. A. Dilmanian
    • Organizer
      CAARI2008
    • Place of Presentation
      Fort Worth, USA
    • Year and Date
      2008-08-15
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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