Development of method of euglycemic hyperinsulinemic glucose clamp technique using analysis of insulin action in peripheral tissue
| Project/Area Number |
20500392
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kumamoto University |
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Principal Investigator |
FURUKAWA Noboru Kumamoto University, 大学院・生命科学研究部, 講師 (90335795)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMODA Seiya 熊本大学, 大学院・生命科学研究部, 助教 (60398203)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | インスリン抵抗性 / グルコースクランプ / two-compartment model / グルコースクランプ法 |
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| Research Abstract |
Analyzing the two-compartment model by using the relationship between plasma and peripheral tissue glucose concentration, we developed the new index α for reflecting the insulin resistance. We demonstrated that highly correlation (r=0.872) between M value and α(60) which was calculated by pattern of glucose infusion rate during 60 min after hyperinsulinemic euglycemic glucose clamp technique. Our results showed that newly developed index α was useful method for evaluating insulin resistance.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Caloric restriction decreases ER stress in liver and adipose tissue in ob/ob mice.2011
Author(s)
Tsutsumi A, Motoshima H, Kondo T, Kawasaki S, Matsumura T, Hanatani S, Igata M, Ishii N, Kinoshita H, Kawashima J, Taketa K, Furukawa N, Tsuruzoe K, Nishikawa T, Araki E
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Journal Title
Biochem Biophys Res Commun. 404
Pages: 339-344
Related Report
Peer Reviewed
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[Journal Article] Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy malesubjects.2010
Author(s)
Kondo T, Sasaki K, Adachi H, Nakayama Y, Hatemura M, Matsuyama R, Tsuruzoe K, Furukawa N, Motoshima H, Morino (Koga) S, Yamashita Y, Miyamura N, Kai H, Araki E
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Journal Title
Obesity Research and Clinical Practice
NAID
Related Report
Peer Reviewed
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[Journal Article] Predictors of coronary heart disease in Japanese patients with type 2 diabetes : Screening for coronary artery stenosis using multidetector computed tomography.2010
Author(s)
Nishioka H, Furukawa N, Shimoda S, Nishida K, Nakaura T, Maeda T, Goto R, Miyamura N, Awai K, Yamashita Y, Araki E
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Journal Title
J Diabetes Invest 1
Pages: 50-55
Related Report
Peer Reviewed
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[Journal Article] Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues.2009
Author(s)
Xue B, Pulinilkunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, Kahn BB.
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Journal Title
Mol Cell Biol. 29
Pages: 4563-4573
Related Report
Peer Reviewed
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[Journal Article] Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis.2009
Author(s)
Adachi H, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N, Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa N, Tsuruzoe K, Kawashima J, Takeya M, Yamashita S, Koh GY, Nagy A, Suda T, Oike Y, Araki E
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Journal Title
Biochem Biophys Res Commun. 379
Pages: 806-1
Related Report
Peer Reviewed
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[Journal Article] Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues.2008
Author(s)
Kojima K, Motoshima H, Tsutsumi A, Igata M, Matsumura T, Kondo T, Kawashima J, Ichinose K, Furukawa N, Inukai K, Katayama S, Goldstein BJ, Nishikawa T, Tsuruzoe K, Araki E
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Journal Title
Biochem Biophys Res Commun. 376
Pages: 434-438
Related Report
Peer Reviewed
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[Presentation] The Effect of a Newly Generated Histone Deacetylase Inhibitor on Gluconeogenesis in Liver.2010
Author(s)
Oiso H, Furukawa N, Suefuji M, Ito A, Furumai R, Nakagawa J, Yoshida M, Nishino N, Araki E
Organizer
The 70th Annual Meeting of American Diabetes Association
Place of Presentation
Orange Country Convention Center, Orlando, USA, Poster
Related Report
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[Presentation] The role of histone deacetylase on gluconeogenesis inliver.2009
Author(s)
Furukawa N, Oiso H, Suefuji M, Ito A, Furumai R, Nakagawa J, Yoshida M, Nishino N, Araki E
Organizer
15th Korea-Japan Symposium of Diabetes Mellitus.
Place of Presentation
International Convention Center Jeju, Jeju island, Korea
Related Report
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[Presentation] アキレス腱反射の定量化の試み2009
Author(s)
西田健朗, 渡辺栄一郎, 岩下真一, 山田聡子, 下田誠也, 水流添覚, 古川昇, 谷川富夫, 廣瀬豊樹, 丸山英樹,荒木栄一
Organizer
第52回日本糖尿病学会総会
Place of Presentation
大阪国際会議場、大阪
Related Report
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