Establishment of early phase dynamic imaging for therapeutic effect of chemotherapeutic agents

• Project/Area Number: 20500395
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Yokohama City University
• Principal Investigator: KUNISAKI Chikara 横浜市立大学, 市民総合医療センター, 教授 (70264611)
• Co-Investigator(Kenkyū-buntansha): KOSAKA Takashi 横浜市立大学, 市民総合医療センター, 助教 (50586906) ; 小野 秀高 横浜市立大学, 消化器・肝移植外科, 助教 (00453051)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 抗癌剤 / 遺伝子治療 / イメージング / 膵癌 / 制限増殖型アデノウイルス / 術中腹腔内イメージング / 化学療法後効果判定

Research Abstract

Conditionally Replicative Adenovirus(CRAd) is useful imaging tool for diagnosse of chemotherapy effect.

Research Products

• [Journal Article] Risk factors for lymph node metastasis in histologically poorly differentiated type early gastric cancer (2009)
  • Author(s): Chikara Kunisaki
  • Journal Title: Endoscopy 41 Pages: 498-503
  • Peer Reviewed
• [Journal Article] Validity of hepatic resection of colorectal liver metastasis in the elderly(75 years and older) (2009)
  • Author(s): Kazunori Nojiri
  • Journal Title: Anticancer Research 29 Pages: 583-588
  • Peer Reviewed
• [Journal Article] Surgical strategy for local recurrence after resection of rectal cancer (2009)
  • Author(s): Shoichi Fujii
  • Journal Title: Hepato-Gastroentegology 56 Pages: 667-671
  • Peer Reviewed
• [Journal Article] Reduction of postoperative abdominal adhesion and leus by a bioresorbable membrane (2009)
  • Author(s): Shoichi Fujii
  • Journal Title: Hepato-Gastroentegology 56 Pages: 725-728
  • Peer Reviewed
• [Journal Article] Evaluation of intraperitoneal lavage cytology before colorectal cancer resection (2009)
  • Author(s): Shoichi Fujii
  • Journal Title: Int J Colorectal Dis 24 Pages: 907-914
  • Peer Reviewed
• [Journal Article] A Y-shaped vinyl hood that creates pneumoperitoneum in laparoscopic rectal cancer surgery(Y-hood method): a new technique for laparoscopiclow anterior resection (2009)
  • Author(s): Shoichi Fujii
  • Journal Title: Surg Endosc (Epub aheed)
  • Peer Reviewed
• [Journal Article] Phase II Study of Weekly Paclitaxel as a Second-line Treatment for S-1-refractory Advanced Gastric Cancer (2009)
  • Author(s): Goro Matsuda
  • Journal Title: Aniticancer Research 29 Pages: 2863-2867
  • Peer Reviewed
• [Journal Article] Efficacy of chemoradiotherapy with low-dose cisplatin and continuous in fusion of 5-fluorouracil for unresectable squamous cell carcinoma of the esophagus (2009)
  • Author(s): Ryo Takagawa
  • Journal Title: Dis Esophagus 22 Pages: 2087-2092
  • Peer Reviewed
• [Journal Article] Predictive factors for surgical complications of laparoscopy-assisted distal gastrectomy for gastric cancer. (2008)
  • Author(s): Chikara Kunisaki
  • Journal Title: Surg Endosc. 12(Epub ahead)
  • NAID: 10030722690
  • Peer Reviewed
• [Journal Article] Phase I study of biweekly docetaxel and S-1 combination chemotherapy for advanced gastric cancer. (2008)
  • Author(s): Chikara Kunisaki
  • Journal Title: Anticancer Research 28 Pages: 2473-8
  • Peer Reviewed
• [Journal Article] Learning curve for laparoscopy-assisted distal gastrectomy with regionallymph node dissection for early gastric cancer. (2008)
  • Author(s): Chikara Kunisaki
  • Journal Title: Sure Laparosc Endosc Percutan Tech. 18 Pages: 236-41
  • Peer Reviewed
• [Journal Article] Impact of palliative gastrectomy in patients with incurable advanced gastric cancer. (2008)
  • Author(s): Chikara Kunisaki
  • Journal Title: Anticancer Research 28 Pages: 1309-15
  • Peer Reviewed
• [Journal Article] The influence of stage migration on the comparison of surgical outcomes between D2 gastrectomy and D3 gastrectomy (para-aortic lymph node dissection) : a multi-institutional retrospective study. (2008)
  • Author(s): Chikara Kunisaki
  • Journal Title: American Journal of Surgery 196 Pages: 358-63
  • Peer Reviewed
• [Journal Article] Prospective randomized controlled trial comparing the use of 3.5-mm and 4.8-mm staples in gastric surgery. (2008)
  • Author(s): Chikara Kunisaki
  • Journal Title: Hepatogastroenterology. 55 Pages: 1943-7
  • Peer Reviewed
• [Journal Article] Tumor diameter as a prognostic factor in patients with gastric cancer. (2008)
  • Author(s): Chikara Kunisaki
  • Journal Title: Ann Sure Oncol. 15 Pages: 1959-67
  • Peer Reviewed
• [Journal Article] Effect of obesity on intraoperative bleeding volume in open gastrectomy with D2 lymph-node dissection for gastric cancer. (2008)
  • Author(s): Makino Hirotomo
  • Journal Title: Patient Saf Surg. 24 Pages: 7-7
  • Peer Reviewed
• [Presentation] 早期胃癌に対する腹腔鏡補助下胃全摘術(LATG)の手技 (2009)
  • Author(s): 國崎主税
  • Organizer: 第71回日本臨床外科学会総会
  • Place of Presentation: 京都
  • Year and Date: 2009-11-21
• [Presentation] 食道癌に対する鏡視下切除術における反回神経周囲リンパ節郭清のコツと治療成績 (2009)
  • Author(s): 國崎主税
  • Organizer: 第71回日本臨床外科学会総会
  • Place of Presentation: 京都
  • Year and Date: 2009-11-20
• [Presentation] 早期胃癌に対する集学的治療における内科医と外科医の接点と役割 (2009)
  • Author(s): 國崎主税
  • Organizer: 第47回日本癌治療学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-23
• [Presentation] 胃癌における標準的腹腔鏡補助下幽門側胃切除術 (2009)
  • Author(s): 牧野洋知
  • Organizer: 第47回日本癌治療学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-23
• [Presentation] 食道癌術後における長期経腸栄養の有用性 (2009)
  • Author(s): 牧野洋知
  • Organizer: 第47回日本癌治療学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-22
• [Presentation] 早期胃癌に対する内視鏡治療の適応拡大と内視鏡手術の役割 (2009)
  • Author(s): 國崎主税
  • Organizer: 第51回日本消化器病学会大会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-15
• [Presentation] 制限増殖型アデノウィルスによる胃癌腹膜播種の治療とイメージング (2009)
  • Author(s): 小坂隆司
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] Impact of lymphovascular invasion in patients with T2N0 gastric cancer (2009)
  • Author(s): 國崎主税
  • Organizer: International Surgical Week 2009
  • Place of Presentation: Adelaide, Australia
  • Year and Date: 2009-09-08
• [Presentation] LADGの手術手技教育標準化 (2009)
  • Author(s): 國崎主税
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-18
• [Presentation] 制限増殖型アデノウイルスによる胃癌腹膜播種の遺伝子治療とイメージング (2009)
  • Author(s): 小坂隆司
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-17
• [Presentation] Stage IV胃癌に対する新規抗癌剤投与による手術の位置づけ (2009)
  • Author(s): 牧野洋知
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-17
• [Presentation] 腹腔鏡補助下幽門側胃切除術における手技に工夫 (2009)
  • Author(s): 國崎主税
  • Organizer: 第34回日本外科系連合学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-19
• [Presentation] Learning curve からみた鏡視下食道切除術の術者育成 (2009)
  • Author(s): 國崎主税
  • Organizer: 第34回日本外科系連合学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-18
• [Presentation] 食道癌に対する鏡視下手術の工夫 (2009)
  • Author(s): 牧野洋知
  • Organizer: 第34回日本外科系連合学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-18
• [Presentation] 壁深達度SE, SI進行胃癌、大腸癌の比較検討 (2009)
  • Author(s): 國崎主税
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-07
• [Presentation] 制限増殖型アデノウィルスベクターによる胃癌腹膜の遺伝子治療とイメージング (2009)
  • Author(s): 小坂隆司
  • Organizer: 第109回日本外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-04-03
• [Presentation] LATGにおけるDST EEA OrVilTM(Tilt-Top Plus)を用いたRoux-en-Y再建法 (2009)
  • Author(s): 國崎主税
  • Organizer: 第109回日本外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-04-03
• [Presentation] 食道癌に対する鏡視下手術のリンパ節郭清術のコツと pitfall (2009)
  • Author(s): 牧野洋知
  • Organizer: 第109回日本外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-04-02
• [Presentation] Conditionally Replicative Adenoviral Vectors for the Treatment and Visu alization of Gastric Cancer (2009)
  • Author(s): 小坂 隆司
  • Organizer: 第81回日本胃癌学会学術総会
  • Place of Presentation: 東京
• [Presentation] 腹腔鏡補助下幽門側胃切除術における肥満の影響 (2008)
  • Author(s): 牧野洋知
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎
• [Presentation] 胃癌に対する非治癒切除術の意義 (2008)
  • Author(s): 小野秀高
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎
• [Presentation] 進行胃癌に対するD2郭清術とD3郭清術(大動脈周囲リンパ節郭清術)の治療成績の比較検討に及ぼすstage migrationの影響 (2008)
  • Author(s): 小坂 隆司
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎
• [Presentation] 進行再発胃癌に対するbi-weekly TS1/Docetaxel 外来併用療法のPhase I study (2008)
  • Author(s): 小野秀高
  • Organizer: 第63回日本消化器外科学会総会
  • Place of Presentation: 札幌
• [Presentation] 上部進行胃癌に対する膵体尾部合併切除後膵液瘻に及ぼす肥満の影響 (2008)
  • Author(s): 小坂 隆司
  • Organizer: 第63回日本消化器外科学会定期学術総会
  • Place of Presentation: 札幌
• [Presentation] 腹腔鏡補助下幽門側胃切除術後B-I法再建 (2008)
  • Author(s): 牧野洋知
  • Organizer: 第34回神奈川胃癌治療研究会
  • Place of Presentation: 東京
• [Presentation] Transient Liver Dysfunction after Laparoscopy-assisted Distal Gastrectomy for Gastric Cancer. (2008)
  • Author(s): 牧野洋知
  • Organizer: 第11回世界内視鏡外科学会
  • Place of Presentation: 横浜
• [Presentation] 腹膜播種を有する胃癌に対する姑息的胃切除術の適応 (2008)
  • Author(s): 小野秀高
  • Organizer: 第46回日本癌治療学会総会
  • Place of Presentation: 名古屋
• [Presentation] Conditionally Replicative Adenoviral Vectors for the Treatment of Gastric Cancer. (2008)
  • Author(s): 小坂 隆司
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
• [Presentation] 制限増殖型アデノウイルスベクターを用いた胃癌微小転移病変のイメージング (2008)
  • Author(s): 小坂 隆司
  • Organizer: 第31回日本分子生物学学会年会
  • Place of Presentation: 神戸