| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Research Abstract |
I investigated clinical significance of vagal nerve stimulation as an adjunct therapy to coronary reperfusion in patients with acute myocardial infarction. Using a rabbit model of myocardial ischemia reperfusion, I disclosed that early short term vagal nerve stimulation in myocardial ischemia reperfusion drastically attenuates cardiac remodeling and prevents cardiac failure in chronic phase. Using dogs, I investigated whether electrical stimulations directly applied to the heart can increase cardiac contractility thereby preventing unwanted side effects such as hypotension seen in vagal nerve stimulation. I disclosed that several methods previously reported failed to increase the contractility constantly in my experimental settings.
|
