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Development of vagal nerve stimulation therapy by computational management of hemodynamics in acute myocardial infarction

Research Project

Project/Area Number 20500404
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

UEMURA Kazunori  National Cardiovascular Center Research Institute, 循環動態制御部, 室長 (10344350)

Co-Investigator(Renkei-kenkyūsha) ZHENG Can  高知大学, 医学部・循環制御学講座, 助教 (50443495)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords急性心筋梗塞 / 迷走神経 / 心室リモデリング / 心不全 / 心筋間質蛋白分解酵素 / 心筋収縮力 / 心臓電気刺激 / 迷走神経刺激 / 電気刺激 / 心室収縮力 / 心臓超音波 / 再灌流療法 / 炎症
Research Abstract

I investigated clinical significance of vagal nerve stimulation as an adjunct therapy to coronary reperfusion in patients with acute myocardial infarction. Using a rabbit model of myocardial ischemia reperfusion, I disclosed that early short term vagal nerve stimulation in myocardial ischemia reperfusion drastically attenuates cardiac remodeling and prevents cardiac failure in chronic phase. Using dogs, I investigated whether electrical stimulations directly applied to the heart can increase cardiac contractility thereby preventing unwanted side effects such as hypotension seen in vagal nerve stimulation. I disclosed that several methods previously reported failed to increase the contractility constantly in my experimental settings.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (34 results)

All 2011 2010 2009 2008 Other

All Journal Article (16 results) (of which Peer Reviewed: 9 results) Presentation (11 results) Remarks (2 results) Patent(Industrial Property Rights) (5 results) (of which Overseas: 3 results)

  • [Journal Article] Peak systolic mitral annulus velocity reflects the status of ventricular-arterial coupling -theoretical andexperimental analyses.2011

    • Author(s)
      Uemura K, Kawada T, Sunagawa K, Sugimachi M
    • Journal Title

      J Am Soc Echocardiogr. 24

      Pages: 582-91

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peak systolic mitral annulus velocity reflects the status of ventricular-arterial coupling-theoretical and experimental analyses.2011

    • Author(s)
      Uemura K, et al.
    • Journal Title

      J Am Soc Echocardiogr.

      Volume: 24(5) Pages: 582-91

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic characteristics of baroreflex neural and peripheral arcs are preserved in spontaneously hypertensive rats.2011

    • Author(s)
      Kawada T, et al.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol.

      Volume: 300(1)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early short-term vagal nerve stimulation attenuates cardiac remodeling after reperfused myocardial infarction.2010

    • Author(s)
      Uemura K, Zheng C, Li M, Kawada T, Sugimachi M
    • Journal Title

      J Card Fail. 16

      Pages: 689-99

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 心筋梗塞に伴う急性心不全および慢性心不全に対する医工学的アプローチ2010

    • Author(s)
      上村和紀, 李梅花, 砂川賢二, 杉町勝
    • Journal Title

      循環器病研究の進歩 31

      Pages: 61-67

    • Related Report
      2010 Final Research Report
  • [Journal Article] 急性心不全におけるコンピュータ制御による包括的な循環管理2010

    • Author(s)
      上村和紀, 杉町勝, 砂川賢二
    • Journal Title

      医学のあゆみ 232

      Pages: 564-569

    • Related Report
      2010 Final Research Report
  • [Journal Article] 急性左心不全の血行動態を自動的に管理する世界初の治療システム開発の試み2010

    • Author(s)
      上村和紀, 杉町勝, 砂川賢二
    • Journal Title

      臨床医のための循環器診療 12

      Pages: 51-53

    • Related Report
      2010 Final Research Report
  • [Journal Article] 心臓機能と循環の統合的理解の進歩-コンピューター制御が可能になった血行動態と心臓エネルギー代謝-2010

    • Author(s)
      上村和紀, 杉町勝, 砂川賢二
    • Journal Title

      循環制御 30

      Pages: 149-156

    • Related Report
      2010 Final Research Report
  • [Journal Article] 心筋梗塞に伴う急性心不全および慢性心不全に対する医工学的アプローチ2010

    • Author(s)
      上村和紀, ら
    • Journal Title

      循環器病研究の進歩

      Volume: 31 Pages: 61-67

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Early Short-Term Vagal Nerve Stimulation Attenuates Cardiac Remodeling After Reperfused Myocardial Infarction.2010

    • Author(s)
      Uemura K, et al.
    • Journal Title

      Journal of Cardiac Failure. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 急性心不全におけるコンピュータ制御による包括的な循環管理2010

    • Author(s)
      上村和紀, 他
    • Journal Title

      医学のあゆみ 232

      Pages: 564-569

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 急性左心不全の血行動態を自動的に管理する世界初の治療システム開発の試み2010

    • Author(s)
      上村和紀, 他
    • Journal Title

      臨床医のための循環器診療 12

      Pages: 51-53

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Computationally managed bradycardia improved cardiac energetics while restoringnormalhemodynamics inheart failure.2009

    • Author(s)
      上村和紀, 砂川賢二, 杉町勝
    • Journal Title

      Ann Biomed Eng. 37

      Pages: 82-93

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of endogenous acetylcholine release during brief ischemia in the rabbit ventricle : a possible trigger for ischemic preconditioning.2009

    • Author(s)
      Kawada T, et al.
    • Journal Title

      Life Science 85

      Pages: 597-601

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Computationally managed bradycardia improved cardiac energetics while restoring normal hemodynamics in heart failure2009

    • Author(s)
      Kazunori Uemura
    • Journal Title

      Ann Biomed Eng 37巻

      Pages: 82-93

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II disproportionally attenuates dynamic vagal and sympathetic heart rate controls2009

    • Author(s)
      Toru Kawada
    • Journal Title

      Am J Physiol Heart Circ Physiol (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Relationship betweenPulse Wave Velocity and the Aortic Input Impedance parameters2011

    • Author(s)
      上村和紀, 他
    • Organizer
      第75回日本循環器学会総会・学術集会
    • Place of Presentation
      横浜(開催予定であったが、東日本大震災により中止となった。)
    • Related Report
      2010 Final Research Report
  • [Presentation] Peak systolic mitral annulus velocity depends on status of ventriculo-arterial coupling2010

    • Author(s)
      Uemura K
    • Organizer
      ESC 2010
    • Place of Presentation
      ストックホルム スェーデン
    • Year and Date
      2010-08-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] Peak Systolic Mitral Annulus Velocity Depends on Status of Ventriculo-arterial Coupling2010

    • Author(s)
      上村和紀, 他
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Peak systolic mitralannulus velocity depends on status of ventriculo-arterial coupling2010

    • Author(s)
      上村和紀, 他
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Continuous monitoringof cardiac output bypressure anddoppler velocity profiles ofeasily accessible peripheral artery2010

    • Author(s)
      上村和紀, 他
    • Organizer
      第49回日本生体医工学会大会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Peak systolic mitralannulus velocity depends on status of ventriculo-arterial coupling2010

    • Author(s)
      上村和紀, 他
    • Organizer
      欧州心臓病学会2010
    • Place of Presentation
      ストックホルム スェーデン
    • Related Report
      2010 Final Research Report
  • [Presentation] 心臓機能と循環の統合的理解の進歩-コンピュータ-制御が可能になった血行動態と心臓エネルギー代謝-2009

    • Author(s)
      上村和紀, 他
    • Organizer
      第30回日本循環制御医学会総会 シンポジウム1
    • Place of Presentation
      鹿児島
    • Year and Date
      2009-06-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Blockade of a7-Nicotinic Acetylcholine Receptors Attenuates Cardio-protective Effects of Donepezil in Rats with Extensive Myocardial Infarction2009

    • Author(s)
      李梅花
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Early short-term vagal nerve stimulation improves left ventricular function and attenuates myocardial structural remodeling after reperfused myocardial infarction2009

    • Author(s)
      上村和紀, 他
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 除細動器・心臓再同期装置に組み込み可能な、心拍出量モニターシステム2009

    • Author(s)
      上村和紀, 他
    • Organizer
      第48回日本生体医工学会大会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 迷走神経を、3日間電気刺激するだけで冠再灌流された心筋梗塞後の心臓リモデリングを改善できる2009

    • Author(s)
      上村和紀, 他
    • Organizer
      第48回日本生体医工学会大会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.ncvc.go.jp/res/divisions/cardiovascular_dynamics/index.html

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 心疾患治療システム2011

    • Inventor(s)
      上村和紀
    • Industrial Property Rights Holder
      国立循環器病研究センター, 他
    • Acquisition Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 心疾患治療システム2010

    • Inventor(s)
      上村和紀, 神谷厚範, 杉町勝, 砂川賢二
    • Industrial Property Rights Holder
      財団法人ヒューマンサイエンス振興財団
    • Acquisition Date
      2010-04-22
    • Related Report
      2010 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 心臓酸素消費量自動最小化システムおよびこれを用いた心疾患治療システム2010

    • Inventor(s)
      杉町勝, 上村和紀, 神谷厚範, 砂川賢二.
    • Industrial Property Rights Holder
      財団法人ヒューマンサイエンス振興財団、株式会社フジキン
    • Acquisition Date
      2010-09-10
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 心疾患治療システム2009

    • Inventor(s)
      上村和紀, 他
    • Industrial Property Rights Holder
      国立循環器病センター総長
    • Acquisition Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 心室容積連続自動測定装置2008

    • Inventor(s)
      砂川賢二、上村和紀
    • Industrial Property Rights Holder
      独立行政法人宇宙航空研究開発機構、独立行政法人国立循環器病研究センター
    • Acquisition Date
      2008-09-26
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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