| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Implantation of autologous cultured periosteal sheets produce clinically effective bone regeneration in periodontal and oral surgical therapy. However, preparation of these sheets usually requires six weeks. To make this therapy more efficient and flexible, we developed a preservation method for the cultured periosteal sheet that maintained biopotency for the clinical application. As a result, we have found that human periosteum tissue segments that pre-cultured for two weeks before cryopreservation maintained their potency of cell growth and responses to standard osteogenic induction at high level after thawing.
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