Development of cryopreservation of cultured periosteum sheets for hard tissue regeneration
| Project/Area Number |
20500406
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomedical engineering/Biological material science
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
KOGAMI Hiroyuki Niigata University, 医歯学系, 助教 (10463978)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAWASE Tomoyuki 新潟大学, 医歯学系, 准教授 (90191999)
OKUDA Kazuhiro 新潟大学, 医歯学系, 准教授 (00169228)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 細胞・組織工学 / 自家移植 / 硬組織再生 / 凍結保存 / 細胞・組織 / 再生医学 |
|---|
| Research Abstract |
Implantation of autologous cultured periosteal sheets produce clinically effective bone regeneration in periodontal and oral surgical therapy. However, preparation of these sheets usually requires six weeks. To make this therapy more efficient and flexible, we developed a preservation method for the cultured periosteal sheet that maintained biopotency for the clinical application. As a result, we have found that human periosteum tissue segments that pre-cultured for two weeks before cryopreservation maintained their potency of cell growth and responses to standard osteogenic induction at high level after thawing.
|
Report
(4 results)
Research Products
(18 results)
