| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Achieving a firm attachment between a tendon and a metal remains a major challenge in orthopedic surgery In this study, we developed a simple model for evaluating the strength of this attachment using bioactive porous titanium, and confirmed whether bone morphogenic protein-2 (BMP-2) can be a help in achieving a firm attachment by ectopic bone formation. Rectangular plate-shaped implants were soak-loaded with BMP-2 (B+ group) and were implanted within the patellar tendon of a rabbit. Implants without BMP-2 (B- group) were used as controls, and they were harvested at 4 and 8 weeks postoperation for mechanical tests and for histological and histomorphometric study. The pull-out failure load of the B+ group was significantly higher than that of the B- group and new bone was more prevalent within the pores and around the implants in the B+ group than in the 13-group.
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