Application of bioactive titanium for high performance orthopedic reconstruction surgery
| Project/Area Number |
20500407
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKEMOTO Mitsuru Kyoto University, 医学研究科, 助教 (00456873)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJIBAYASHI Syunsuke 京都大学, 医学研究科, 助教 (30362502)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 人工骨 / 多孔性チタン / 生体活性 / BMP / 軟部組織接着能 / Rapid prototyping / レーザープリンティング |
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| Research Abstract |
Achieving a firm attachment between a tendon and a metal remains a major challenge in orthopedic surgery In this study, we developed a simple model for evaluating the strength of this attachment using bioactive porous titanium, and confirmed whether bone morphogenic protein-2 (BMP-2) can be a help in achieving a firm attachment by ectopic bone formation. Rectangular plate-shaped implants were soak-loaded with BMP-2 (B+ group) and were implanted within the patellar tendon of a rabbit. Implants without BMP-2 (B- group) were used as controls, and they were harvested at 4 and 8 weeks postoperation for mechanical tests and for histological and histomorphometric study. The pull-out failure load of the B+ group was significantly higher than that of the B- group and new bone was more prevalent within the pores and around the implants in the B+ group than in the 13-group.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Osteoinduction of porous Ti implants with a channel structure fabricated by selective laser melting.2011
Author(s)
Fukuda A, Takemoto M, Saito T, Fujibayashi S , Neo M, Pattanayak DK, Matsushita T, Sasaki K, Nishida N, Kokubo T, Nakamura T.
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Journal Title
Acta Biomater. 7(5)
Pages: 2327-2336
Related Report
Peer Reviewed
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