| Project/Area Number |
20500410
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kyushu University |
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Principal Investigator |
KANO Arihiro Kyushu University, 先導物質化学研究所, 准教授 (30403950)
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| Co-Investigator(Renkei-kenkyūsha) |
MARUYAMA Atsushi 九州大学, 先導物質化学研究所, 教授 (40190566)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 薬物伝達システム / 核酸医薬 / カチオン性高分子 / 腫瘍集積性 / 高分子構造・物性 / 生体材料 / 癌 / 光線力学療法 / PEG / PLL / 共重合体 |
|---|
| Research Abstract |
We previously showed that polyethyleneglycol-grafted poly-L-lysine (PLL-g-PEG) exerts long lifetime of nucleic acids medicine, such as siRNA, in blood circulation. It is conceivable that PLL-g-PEG is useful as a drug delivery carrier for tumor treatment. In this study, we examined the effects of PEG grafting ratio and the length of the PEG chain and PLL backbone on the stability of siRNA/PLL-g-PEG complex and the tumor accumulation. As the results, it was revealed that the higher PEG-grafted PLL, more than 30%, is efficiently accumulated in tumor tissues and even the affinity to the siRNA is augmented.
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