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Expression of bioactivity through nano-sized defects and its regulation

Research Project

Project/Area Number 20500413
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionMeiji University

Principal Investigator

AIZAWA Mamoru  Meiji University, 理工学部, 教授 (10255713)

Co-Investigator(Renkei-kenkyūsha) MATSUMOTO Morio  慶應義塾大学, 医学部, 准教授 (40209656)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords水酸アパタイト / 欠陥構造 / 透過型電子顕微鏡 / 骨芽細胞 / 生体活性 / 多孔質セラミックス / 骨伝導(生体活性) / 骨誘導 / 電子顕微鏡 / バイオセラミックス / アパタイト / 生体材料 / セラミックス / 細胞・組織 / ナノ構造
Research Abstract

Biological apatite presented in bone and teeth of mammals contains various minerals, and has lots of defects with nano-scale sizes in the crystal structure. In the present study, we fabricated hydroxyapatite ceramics including bone minerals (bone HAp ceramics) as model materials to clarify the relationship between nano-defect structure and bioactivity of biological apatite. The results of high-resolution transmission electron microscope (HR-TEM) revealed that bone HAp ceramics contained more defects and strains compared to pure HAp ceramics. In addition, osteoblasts derived from rat bone marrow cells were seeded on bone HAp ceramics, together with pure HAp ceramics as a control. The bone HAp ceramics promoted the differentiation into osteoblast compared to pure HAp ceramics. The present bone HAp ceramics may be expected as next-generation artificial bone graft.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (65 results)

All 2011 2010 2009 2008 Other

All Journal Article (18 results) (of which Peer Reviewed: 17 results) Presentation (44 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Cell proliferation, morphology and differentiation of Transgenic-cloned pig calvarial osteoblasts on the silicon-substituted hydorxyapatite ceramics fabricated viaultrasonic spray-pyrolysis technique2011

    • Author(s)
      M.Honda, K.Kikushima, T.Konishi, M.Mizumoto, H.Matsunari, H.Nagashima, M.Aizawa
    • Journal Title

      J.Aust.Ceram.Soc 47

      Pages: 37-41

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell proliferation, morphology and differentiation of Transgenic-cloned pig calvarial osteoblasts on the silicon-substituted hydorxyapatite ceramics fabricated via ultrasonic spray-pyrolysis technique2011

    • Author(s)
      M.Honda, K.Kikushima, T.Konishi, M.Mizumoto, H.Matsunari, H.Nagashima, M.Aizawa
    • Journal Title

      J.Aust.Ceram.Soc.

      Volume: 47 Pages: 37-41

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical composition and ultrastructure of apatite ceramics including bone minerals2010

    • Author(s)
      T.Miki, T.Fujino, Y.Yasutomi, T.Fukazawa, H.Yoshimura , M.Aizawa
    • Journal Title

      Archives of BioCeramics Research 10

      Pages: 141-144

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of biocompatible apatite sheets with various Ca/Pratios and carbonate ion contents for mouse osteoblastic cell culture and their evaluation2010

    • Author(s)
      H.Ueno, T.J.Fujimi, I.Okada, M.Aizawa
    • Journal Title

      J.Aust.Ceram.Soc 46

      Pages: 14-18

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Topographical analyses of proliferation and differentiation of osteoblasts in micro- and macro pores of apatite-fiber scaffold2010

    • Author(s)
      M.Honda, T.Fujimi, S.Izumi, K.Izawa, M.Aizawa, H.Morisue, T.Tsuchiya, N.Kanzawa
    • Journal Title

      J.Biomed.Mater.Res. : Part A 94A

      Pages: 937-944

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of biocompatible apatite sheets with various Ca/P ratios and carbonate ion contents for mouse osteoblastic cell culture and their evaluation2010

    • Author(s)
      H.Ueno, J.T.Fujimi, I.Okada, M.Aizawa
    • Journal Title

      J.Aust.Ceram.Soc.

      Volume: 46 Pages: 14-18

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical composition and ultrastructure of apatite ceramics including bone minerals2010

    • Author(s)
      T.Miki, T.Fujino, Y.Yasutomi, T.Fukazawa, H.Yoshimura, M.Aizawa
    • Journal Title

      Archives of BioCeramics Research

      Volume: 10 Pages: 141-144

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topographical analyses of proliferation and differentiation of osteoblasts in micro- and macro pores of apatite-fiber scaffold2010

    • Author(s)
      M.Honda, T.Fujimi, S.Izumi, K.Izawa, M.Aizawa, H.Morisue, T.Tsuchiya, N.Kanzawa
    • Journal Title

      J.Biomed.Mater.Res.: Part A

      Volume: 94A Pages: 937-944

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Silicon-substituted hydroxyapatite powders Prepared by ultrasonic spray-pyrolysis technique2009

    • Author(s)
      K.Kikushima, H.Yoshihisa, M.Aizawa
    • Journal Title

      Bioceramics 22

      Pages: 79-82

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of chelate-setting cement using apatite powder including bone minerals and its property2009

    • Author(s)
      T.Fujii, T.Fujino, S.Sato, K.Oribe, M.Aizawa
    • Journal Title

      Bioceramics 22

      Pages: 875-878

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of chelate-setting cements from silicon-substituted apatite powder prepared by ultrasonic spray-pyrolysis technique and its property2009

    • Author(s)
      K.Kikushima, K.Oribe, M.Aizawa
    • Journal Title

      Archives of BioCeramics Research 9

      Pages: 331-334

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo bone formation using three-dimensional scaffolds developed from a single crystal apatite fiber2009

    • Author(s)
      H.Morisue, M.Matsumoto, K.Chiba, H.Matsumoto, Y.Toyama, M.Aizawa, N.Kanzawa, T.J.Fujimi, H.Uchida, I.Okada
    • Journal Title

      J.Biomed.Mater.Res.A 90A

      Pages: 811-818

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] バイオセラミックスルネッサンス-次世代バイオセラミックスの二つの潮流-2009

    • Author(s)
      相澤守
    • Journal Title

      バイオマテリアル 27

      Pages: 73-74

    • NAID

      10024786290

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] バイオセラミックスルネッサンス -次世代バイオセラミックスの二つの潮流-2009

    • Author(s)
      相澤守
    • Journal Title

      バイオマテリアル 27

      Pages: 73-74

    • NAID

      10024786290

    • Related Report
      2009 Annual Research Report
  • [Journal Article] In vivo bone formation using three-dimensional scaffolds developed from a single crystal apatite fiber2009

    • Author(s)
      H. Morisue, M. Aizawa, 他
    • Journal Title

      J. Biomed. Mater. Res. A (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microstructural observation of calcium-deficient single crystal apatite fibers and phase changes during heating2008

    • Author(s)
      A.Taki, H.Yoshimura, M.Aizawa
    • Journal Title

      Key Engineer.Mater

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microenvironment of apatite-fiber scaffolda ffects cell proliferation and resulting cell differentiation2008

    • Author(s)
      M.Honda, S.Izumi, N.Kanzawa, T.Tsuchiya, M.Aizawa
    • Journal Title

      Key Engineer.Mater

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microstructural observation of calcium-deficient single crystalapatite fibers and phase changes during heating2008

    • Author(s)
      A. Taki, H. Yoshimura, M. Aizawa
    • Journal Title

      Key Eng 361-363

      Pages: 147-150

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] クサビラオレンジ蛍光遺伝子を導入したブタを用いた二極化した細孔構造を備えたβ-リン酸三カルシウム多孔体のin vivo 評価2011

    • Author(s)
      重光勇介・本田みちよ・水本みのり・松成ひとみ・竹内靖浩・長嶋比呂志・相澤守
    • Organizer
      日本セラミックス協会2011年年会
    • Place of Presentation
      静岡大学(浜松キャンパス)、日本セラミックス協会
    • Related Report
      2010 Final Research Report
  • [Presentation] クサビラオレンジブタ脛骨埋入による高強度化アパタイトファイバースキャフォルドの生体適合性評価2011

    • Author(s)
      鴈本拓也・島田愛生・安冨由美子・本田みちよ・水本みのり・松成ひとみ・竹内靖浩・長嶋比呂志・相澤守
    • Organizer
      日本セラミックス協会2011年年会
    • Place of Presentation
      静岡大学(浜松キャンパス)、日本セラミックス協会
    • Related Report
      2010 Final Research Report
  • [Presentation] クサビラオレンジ蛍光遺伝子を導入したブタを用いた二極化した細孔構造を備えたβ-リン酸三カルシウム多孔体のin vivo評価2011

    • Author(s)
      重光勇介・本田みちよ・水本みのり・松成ひとみ・竹内靖浩・長嶋比呂志・相澤守
    • Organizer
      日本セラミックス協会2011年年会
    • Place of Presentation
      静岡大学(浜松キャンパス)
    • Related Report
      2010 Annual Research Report
  • [Presentation] クサビラオレンジブタ脛骨埋入による高強度化アパタイトファイバースキャフォルドの生体適合性評価2011

    • Author(s)
      鴈本拓也・島田愛生・安冨由美子・本田みちよ・水本みのり・松成ひとみ・竹内靖浩・長嶋比呂志・相澤守
    • Organizer
      日本セラミックス協会2011年年会
    • Place of Presentation
      静岡大学(浜松キャンパス)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ケイ素含有アパタイトファイバーによる骨再生用スキャフォルドの作製とその評価2011

    • Author(s)
      木下友花里・S.M.Best・相澤守
    • Organizer
      日本セラミックス協会2011年年会
    • Place of Presentation
      静岡大学(浜松キャンパス)
    • Related Report
      2010 Annual Research Report
  • [Presentation] クサビラオレンジブタ頭蓋骨より単離した骨芽細胞の骨分化過程の解析2010

    • Author(s)
      本田みちよ・水本みのり・小西敏功・松成ひとみ・長嶋比呂志・相澤守
    • Organizer
      日本セラミックス協会生体関連材料部会第14回生体関連セラミックス討論会
    • Place of Presentation
      京都(京都テルサ)、日本セラミックス協会生体関連材料部会
    • Year and Date
      2010-12-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 二極化した細孔構造をそなえたβ-リン酸三カルシウム多孔体の作製と評価2010

    • Author(s)
      重光勇介・相澤守
    • Organizer
      日本セラミックス協会生体関連材料部会 第14回生体関連セラミックス討論会
    • Place of Presentation
      京都(京都テルサ)
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of Apatite-fiber Scaffolds for Tissue Engineering and Their Application to Bone and Liver Regenerations2010

    • Author(s)
      Mamoru Aizawa
    • Organizer
      Research Seminar : Angiogenesis Inhibition in Cancer and Biomaterial Scienc
    • Place of Presentation
      Health Science University of Mongolia(Invited lecture)
    • Year and Date
      2010-06-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cell proliferation, morphology and differentiation of Transgenic-clonedpig calvarial osteoblasts on the silicon-substituted hydorxyapatite ceramics fabricated via ultrasonic spray-pyrolysis technique2010

    • Author(s)
      M.Honda, K.Kikushima, T.Konishi, M.Mizumoto, H.Matsunari, H.Nagashima, M.Aizawa
    • Organizer
      International Symposium on Apatites and Correlative Biomaterials (ISACB 2010Sympsium)
    • Place of Presentation
      Cairns Convention Centre, Cairns, Australia
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨ミネラル含有アパタイトセラミックスによる骨芽細胞の分化誘導2010

    • Author(s)
      安冨由美子・三木拓也・相澤守
    • Organizer
      第32回日本バイオマテリアル学会大会
    • Place of Presentation
      広島,日本バイオマテリアル学会
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨ミネラル含有アパタイトセラミックスの化学組成とその超微細構造Q2010

    • Author(s)
      三木拓也・藤野匡敏・安冨由美子・深澤倫子・吉村英恭・相澤守
    • Organizer
      第32回日本バイオマテリアル学会大会
    • Place of Presentation
      広島,日本バイオマテリアル学会
    • Related Report
      2010 Final Research Report
  • [Presentation] ケイ素含有アパタイトセラミックス上で培養した骨芽細胞の増殖・形態および分化2010

    • Author(s)
      本田みちよ・菊島光一・水本みのり・小西敏功・相澤守
    • Organizer
      第32回日本バイオマテリアル学会大会
    • Place of Presentation
      広島,日本バイオマテリアル学会
    • Related Report
      2010 Final Research Report
  • [Presentation] Reconstruction of tissue-engineered bone through combination of an apatite-fiber scaffold, a radial-flow bioreactor and rat bone marrow cells2010

    • Author(s)
      J.Fukasawa, Y.Nakada, H.Maehashi, T.Matsuura, M.Aizawa
    • Organizer
      The 3rd International Congress on Ceramics (ICC3)
    • Place of Presentation
      Osaka International Convention Center, Osaka
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Chemical composition and ultrastructure of apatite ceramics including bone minerals2010

    • Author(s)
      T.Miki, T.Fujino, Y.Yasutomi, T.Fukazawa, H.Yoshimura, M.Aizawa
    • Organizer
      10th Asian BioCeramics Symposium 2010 (ABC 2010)
    • Place of Presentation
      Yogyakarta Prime Plaza Hotel, Yogyakarta, Indonesia
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] クサビラオレンジ蛍光遺伝子を導入したブタを用いた高強度化アパタイトファイバースキャフォルドのinvivo評価2010

    • Author(s)
      鴈本拓也・島田愛生・安冨由美子・本田みちよ・水本みのり・松成ひとみ・竹内靖浩・長嶋比呂志・相澤守
    • Organizer
      第20回無機リン化学討論会、宮城(東北大学青葉山キャンパス)
    • Place of Presentation
      日本無機リン化学会
    • Related Report
      2010 Final Research Report
  • [Presentation] ホウ素含有アパタイトセラミックスの特性評価2010

    • Author(s)
      市村達哉・三木拓也・相澤守
    • Organizer
      無機マテリアル学会第120回学術講演会
    • Place of Presentation
      上智大学(中央図書館)、無機マテリアル学会
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨ミネラル含有アパタイトセラミックスの化学組成と微細構造2010

    • Author(s)
      三木拓也・藤野匡敏・吉村英恭・相澤守
    • Organizer
      日本セラミックス協会2010年年会
    • Place of Presentation
      東京農工大学(小金井キャンパス)、日本セラミックス協会
    • Related Report
      2010 Final Research Report
  • [Presentation] ホウ素含有アパタイトセラミックスの特性評価2010

    • Author(s)
      市村達哉・三木拓也・相澤守
    • Organizer
      無機マテリアル学会第120回学術講演会
    • Place of Presentation
      上智大学(中央図書館)
    • Related Report
      2010 Annual Research Report
  • [Presentation] クサビラオレンジ蛍光遺伝子を導入したブタを用いた高強度化アパタイトファイバースキャフォルドのin vivo評価2010

    • Author(s)
      鴈本拓也・島田愛生・安冨由美子・本田みちよ・水本みのり・松成ひとみ・竹内靖浩・長嶋比呂志・相澤守
    • Organizer
      第20回無機リン化学討論会
    • Place of Presentation
      宮城(東北大学青葉山キャンパス)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨ミネラル含有アパタイトセラミックスによる骨芽細胞の分化誘導2010

    • Author(s)
      安冨由美子・三木拓也・相澤守
    • Organizer
      第32回日本バイオマテリアル学会大会
    • Place of Presentation
      広島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨ミネラル含有アパタイトセラミックスの化学組成とその超微細構造2010

    • Author(s)
      三木拓也・藤野匡敏・安冨由美子・深澤倫子・吉村英恭・相澤守
    • Organizer
      第32回日本バイオマテリアル学会大会
    • Place of Presentation
      広島
    • Related Report
      2010 Annual Research Report
  • [Presentation] ケイ素含有アパタイトセラミックス上で培養した骨芽細胞の増殖・形態および分化2010

    • Author(s)
      本田みちよ・菊島光一・水本みのり・小西敏功・相澤守
    • Organizer
      第32回日本バイオマテリアル学会大会
    • Place of Presentation
      広島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛍光タンパク質を用いた生体材料の骨誘導能評価システムの構築2010

    • Author(s)
      初川淳一・湯沢琴・相澤守・神澤信行
    • Organizer
      第32回日本バイオマテリアル学会大会
    • Place of Presentation
      広島
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of biocompatible apatite sheets with various Ca/P ratios and carbonate ion contents for mouse osteoblastic cell culture and their evaluation2010

    • Author(s)
      H.Ueno, T.J.Fujimi, I.Okada, M.Aizawa
    • Organizer
      International Symposium on Apatites and Correlative Biomaterials (ISACB 2010 Sympsium)
    • Place of Presentation
      Cairns Convention Centre, Cairns, Australia
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cell proliferation, morphology and differentiation of Transgenic-cloned pig calvarial osteoblasts on the silicon-substituted hydorxyapatite ceramics fabricated via ultrasonic spray-pyrolysis technique2010

    • Author(s)
      M.Honda, K.Kikushima, T.Konishi, M.Mizumoto, H.Matsunari, H.Nagashima, M.Aizawa
    • Organizer
      International Symposium on Apatites and Correlative Biomaterials (ISACB 2010 Sympsium)
    • Place of Presentation
      Cairns Convention Centre, Cairns, Australia
    • Related Report
      2010 Annual Research Report
  • [Presentation] Fabrication of chelate-setting cements from silicon-substituted apatite powder prepared by ultrasonic spray-pyrolysis technique and its property2009

    • Author(s)
      K.Kikushima, K.Oribe, M.Aizawa
    • Organizer
      Asia BioCeramics Symposium 2009 (ABC2009)
    • Place of Presentation
      Nagoya,Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Preparation of Silicon-substituted hydroxyapatite powders by ultrasonic spray-pyrolysis technique and its sinterability2009

    • Author(s)
      K.Kikushima, H.Yoshihisa, M.Aizawa
    • Organizer
      The 26th International Japan-Korea Seminar on Ceramics
    • Place of Presentation
      Tsukuba, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨ミネラル含有アパタイトを出発原料としたキレート硬化型セメントの作製とその材料特性2009

    • Author(s)
      藤井拓也・藤野匡敏・水本みのり・佐藤静磨・織部一弥・相澤守
    • Organizer
      第31回日本バイオマテリアル学会大会
    • Place of Presentation
      京都,日本バイオマテリアル学会
    • Related Report
      2010 Final Research Report
  • [Presentation] ホウ素含有アパタイトセラミックスの作製とその評価2009

    • Author(s)
      市村達哉・相澤守
    • Organizer
      第199回学術講演会
    • Place of Presentation
      大垣,無機マテリアル学会
    • Related Report
      2010 Final Research Report
  • [Presentation] Fabrication of chelate-setting cement using apatite powder including bone minerals and its property2009

    • Author(s)
      T.Fujii, T.Fujino, S.Sato, K.Oribe,M.Aizawa
    • Organizer
      22^<nd> International Symposium on Ceramics in Medicine (ISCM)
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Characterization of Silicon-substituted hydroxyapatite powders Prepared by ultrasonic spray-pyrolysis technique2009

    • Author(s)
      K.Kikushima, H.Yoshihisa, M.Aizawa
    • Organizer
      22^<nd> International Symposium on Ceramics in Medicine (ISCM)
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 超音波噴霧熱分解法を用いて調製したケイ素含有アパタイトによるキレート硬化型セメントの作製とその評価2009

    • Author(s)
      菊島光一,織部一弥,相澤守
    • Organizer
      第19回無機リン化学討論会
    • Place of Presentation
      東京医科歯科大学,日本無機リン化学会
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨ミネラル含有アパタイトを用いたキレート硬化型セメントの作製とその材料特性2009

    • Author(s)
      藤井拓也・藤野匡敏・水本みのり・佐藤静磨・織部一弥・相澤守
    • Organizer
      日本セラミックス協会2009年年会
    • Place of Presentation
      東京理科大学(野田キャンパス)、日本セラミックス協会
    • Related Report
      2010 Final Research Report
  • [Presentation] 超音波噴霧熱分解法を用いて調製したケイ素含有アパタイトによるキレート硬化型セメントの作製とその評価2009

    • Author(s)
      菊島光一, 織部一弥, 相澤守
    • Organizer
      第19回無機リン化学討論会
    • Place of Presentation
      東京医科歯科大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨ミネラル含有アパタイトを出発原料としたキレート硬化型セメントの作製とその材料特性2009

    • Author(s)
      藤井拓也, 藤野匡敏, 水本みのり, 佐藤静磨, 織部一弥, 相澤守
    • Organizer
      第31回日本バイオマテリアル学会大会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Preparation of Silicon-substituted hydroxyapatite powders by ultrasonic spray-pyrolysis technique and its sinterability2009

    • Author(s)
      K.Kikushima, H.Yoshihisa, M.Aizawa
    • Organizer
      The 26^<th> International Japan-Korea Seminar on Ceramics
    • Place of Presentation
      Tsukuba, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fabrication of chelate-setting cements from silicon-substituted apatite powder prepared by ultrasonic spray-pyrolysis technique and its property2009

    • Author(s)
      K.Kikushima, K.Oribe, M.Aizawa
    • Organizer
      Asia BioCeramics Symposium 2009 (ABC2009)
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fabrications of hydroxyapatite ceramics including bone minerals and their microstructure2008

    • Author(s)
      T.Fujino, Y.Sekine, T.Fukazawa, H.Yoshimura, M.Aizawa
    • Organizer
      The IUMRS International Conference in Asia2008
    • Place of Presentation
      Nagoya Congress Center
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨ミネラル含有アパタイトセラミックスの特性評価2008

    • Author(s)
      藤野匡敏・関根由莉菜・深澤倫子・吉村英恭・相澤守
    • Organizer
      無機マテリアル学会第117回学術講演会
    • Place of Presentation
      沖縄(沖縄県立博物館・美術館),無機マテリアル学会
    • Related Report
      2010 Final Research Report
  • [Presentation] 超音波噴霧熱分解法によるケイ素含有アパタイトの合成とその粉体性状2008

    • Author(s)
      菊島光一・吉久甫・相澤守
    • Organizer
      日本無機リン化学会第18回無機リン化学討論会
    • Place of Presentation
      奈良(奈良新公会堂)、日本無機リン化学会
    • Related Report
      2010 Final Research Report
  • [Presentation] Preparation of apatite powder including bone minerals and its ceramics processing2008

    • Author(s)
      T.Fujino, M.Aizawa
    • Organizer
      8th World Biomaterials Congress (WBC)
    • Place of Presentation
      Amsterdam Netherland
    • Related Report
      2010 Final Research Report
  • [Presentation] Preparation of apatite powder including bone minerals and its ceramics processing2008

    • Author(s)
      T. Fujino, M. Aizawa
    • Organizer
      8^<th> World Biomaterials Congress (WBC)
    • Place of Presentation
      Amsterdam, Netherland
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨ミネラル含有アパタイトセラミックスの特性評価2008

    • Author(s)
      藤野匡敏, 関根由莉菜, 深澤倫子, 吉村英恭, 相澤守
    • Organizer
      無機マテリアル学会第117回学術講演会
    • Place of Presentation
      沖縄(沖縄県立博物館・美術館)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Fabrications of hydroxy apatite ceramics including boneminerals and their microstructure2008

    • Author(s)
      T. Fujino, Y. Sekine, T. Fukazawa, H. Yoshimura, M. Aizawa
    • Organizer
      The IUMRS International Conference in Asia 2008
    • Place of Presentation
      Nagoya Congress Center
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.isc.meiji.ac.jp/~chem/aizawa

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.isc.meiji.ac.jp/~chem/aizawa/aizawa.html

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] リン酸カルシウム多孔体およびその製造方法2011

    • Inventor(s)
      相澤守・重光勇介・長嶋比呂志
    • Industrial Property Rights Holder
      学校法人明治大学・昭和医科工業
    • Industrial Property Number
      2011-062997
    • Filing Date
      2011-03-22
    • Related Report
      2010 Annual Research Report 2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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