Basic Approach on Novel Synthetic Pulmonary Surfactant as Intelligent Nano-Medicine
| Project/Area Number |
20500414
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomedical engineering/Biological material science
|
|---|
| Research Institution | Nagasaki International University |
|---|
Principal Investigator |
SHIBATA Wosamu Nagasaki International University, 薬学部・薬学科, 教授 (10117129)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAKAHARA Hiromichi 長崎国際大学, 薬学部・薬学科, 助教 (00513235)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 肺サーファクタント / ナノ医薬 / 超薄膜 / 表面・界面物性 / インテリジェント・ナノ材料 / Langmuir単分子膜 / 表面電位-面積等温線 / 原子間力顕微鏡(AFM) / 蛍光顕微鏡(FM) / 偏光変調赤外反射吸収法(PM-IRRAS) / 肺サーファクタン / 表面・界面特性 / 偏光変調反射赤外分光法 / 原子間力顕微鏡 / 蛍光顕微鏡 / 多角入射分解分光法 |
|---|
| Research Abstract |
Our novel lung surfactant (LS) preparations show following : An electrostatic interaction between phosphatidylglycerol and peptide prevents irreversible transformation for the peptide from α-helix to β-sheet structures. And added partially fluorinated amphiphiles may be useful potential additives for synthetic LS preparations destined for treatment of RDS in premature infants and in adults.
|
Report
(4 results)
Research Products
(159 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Book] Mode of interaction of artificial pulmonary surfactant with an amphiphilic α-helical peptide at the air/water interface, Colloids in Biotechnology, Surfactant Science Series 152, M.Fanun, Ed.2010
Author(s)
O.Shibata, H.Nakahara, S.Lee
Total Pages
29
Publisher
CRC Press, Boca Raton, FL, 2010, pp9-38 SBN978-1-4398-3080-2-9000
Related Report
-
-
[Book] Influence of pulmonary surfactant protein mimics on model lung surfactant, In Biobased Surfactants and Detergents : Synthesis, Properties, and Applications, D.G.Hayes, D.Kitamoto, D.K.Y.Solaiman, R.D.Ashby, Eds.2009
Author(s)
H.Nakahara, S.Lee, O.Shibata^*
Total Pages
33
Publisher
AOCS Press, Urbana, IL, USA, 2009, pp157-190 SBN978-189399767-7-9000
Related Report
-
-
-
-
-
-
-
-
-
