| Project/Area Number |
20500415
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
RUMIANA Bakalova National Institute of Radiological Sciences, 分子イメージング研究センター, 主任研究員 (30469936)
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| Research Collaborator |
AOKI Ichio 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (10319519)
ZHIVKO Zhelev 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任技術員 (60511532)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ナノバイオ材料 / 分子イメージング / 複合画像 / 量子ドット / MRI / 蛍光イメージング / マルチプローブ / シリカ / 大腸がん / 大腸癌 / マルチモーダル / in vivoイメージング / 腫瘍 |
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| Research Abstract |
The purpose of these experiments is to clarify whether this probe is appropriate for early diagnostics of colon cancer using combined fluorescence/MR imaging. We applied two multimodal quantum dot probes (QD-probe) for cancer imaging in experimental animals, using fluorescent imaging and magnetic resonance imaging. QD-probe (conjugated with PEG and B72.3 using carbodiimide) was injected into the tail vain of the mouse. 7T-MRI and optical imaging allows visualization of the tumor in the early stage. Our research has been reported as manuscripts in peer-reviewed journals and presentations on scientific conferences.
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