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To evaluate the effect of low reactive level laser on overactive bladder

Research Project

Project/Area Number 20500417
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionChiba University

Principal Investigator

UCHIYAMA Tomoyuki  Chiba University, 医学部附属病院, 助教 (70345015)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Tatsuya  千葉大学, 医学部附属病院, 助教 (50375755)
Research Collaborator YAMAGUCHI Chiharu  千葉大学, 医学部附属病院, 検査技師
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords神経因性膀胱 / 過活動膀胱 / 排尿障害 / レーザー / 頻尿
Research Abstract

We reconsidered the effect of low reactive level laser on bladder function in normal rats and overactive bladder in rats with various conditions such as spinal cord injury, Parkinson's disease and cystitis, and evaluated the safety of this new method. Based on these results, we apply for a patent in Japan and we decided to apply for a investigator-initiated trial to institutional review board/ethics committees in our hospital. We also developed a new method and devise by using near-infrared spectroscopy (NIRS) to evaluate urinary urgency as a main symptom of overactive bladder and detrusor overactivity as a pathologic background of overactive bladder. And we evaluated and considered the usefulness of this method and device in human. We also apply for a patent in Japan about this new idea.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (13 results)

All 2010 2009 2008 Other

All Presentation (7 results) Remarks (3 results) Patent(Industrial Property Rights) (3 results)

  • [Presentation] Real time change in prefrontal cortex related to normal and overactive bladder: A functional near-infrared spectroscopy(fNIRS)study2010

    • Author(s)
      山口千晴、内山智之, ほか
    • Organizer
      International Continence Society 2010
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Real time change in prefrontal cortex related to normal and overactive bladder : A functional near-infrared spectroscopy (fNIRS) study.2010

    • Author(s)
      山口千晴、内山智之
    • Organizer
      International Continence Society
    • Place of Presentation
      トロント、カナダ
    • Related Report
      2010 Final Research Report
  • [Presentation] 蓄尿に関連した前頭前野の特異的かつ経時的な活動について2010

    • Author(s)
      山口千晴、内山智之
    • Organizer
      日本老年泌尿器学会
    • Place of Presentation
      東京、東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 蓄尿およびその異常に関連した前頭前野の特異的かつ経時的な活動について2010

    • Author(s)
      山口千晴、内山智之
    • Organizer
      日本排尿機能学会
    • Place of Presentation
      甲府、山梨
    • Related Report
      2010 Final Research Report
  • [Presentation] Photo-stimulating effects of low reactive level laser on micturition function in rats2009

    • Author(s)
      内山智之
    • Organizer
      6^<th> Annual Meeting of International Society for Autonomic Neuroscience
    • Place of Presentation
      シドニー オーストラリア
    • Year and Date
      2009-09-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Low reactive level laser ameliorate storage dysfunction without aggravating voiding function.2009

    • Author(s)
      内山智之
    • Organizer
      International Continence Society
    • Place of Presentation
      サンフランシスコ、米国
    • Related Report
      2010 Final Research Report
  • [Presentation] Photo-stimulating effects of low reactive level laser on micturition function.2009

    • Author(s)
      内山智之
    • Organizer
      6^<th> Annual Meeting of International Society for Autonomic Neuroscience
    • Place of Presentation
      シドニー、オーストラリア
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks] H20年度千葉大学新技術説明会「レーザーを用いた排尿障害の新規治療法および治療機器」

    • URL

      http://jstshingi.jp/abst/p/08/828/chiba9.pdf

    • Related Report
      2010 Final Research Report
  • [Remarks] H22年度千葉大学新技術説明会「近赤外線分光法を用いた新たな排尿機能検査法」

    • URL

      http://www.jstshingi.jp/abst/p/10/1062/chiba8.pdf

    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 排尿障害の診断・病態解析に対する近赤外分析装置の用途2010

    • Inventor(s)
      山口千晴、内山智之、山本達也、柳澤充、桑原聡、野村文夫、榊原隆次
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Number
      2010-189954
    • Filing Date
      2010-08-26
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 排尿障害の診断・病態解析に対する近赤外分析装置の用途2010

    • Inventor(s)
      山口千晴, 内山智之
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Number
      2010-189954
    • Filing Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 排尿障害の改善及び/又は治療に使用するレーザーの用途2008

    • Inventor(s)
      内山智之
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Number
      2008-012066
    • Filing Date
      2008-01-22
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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