| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Research Abstract |
METHODS : We obtained basal and apical LV short-axis views in 27 patients with non-obstructive HCM and 25 healthy volunteers. Eight equiangular points on the endo-myocardium at end-diastole were placed in each view, and the movements of these points were automatically tracked using a two-dimensional echocardiographic tissue tracking system. Time-LV radial shortening curves were obtained and averaged. The time intervals from the aortic valve closure to the point of the first 40% of peak lengthening (T_<40>) were measured in each view. RESULTS : The time difference in the T_<40> between the apex and base (Δ-T_<40>) in the HCM group was greater than that in the control group. There were good linear correlations between the Δ-T_<40> and the LV early diastolic echo-parameters and the LV mass index. CONCLUSIONS : Our results suggested that apical non-uniformity resulted in loss of active mechanical coordination of apex-to-basal lengthening, which could contribute to global LV diastolic impairment.
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