Relation of apex-to-base dispersion in diastolic lengthening to left ventricular diastolic function evaluated by tissue tracking system
| Project/Area Number |
20500420
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Yamaguchi University |
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Principal Investigator |
MURATA Kazuya Yamaguchi University, 医学部・附属病院, 講師 (60314803)
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| Co-Investigator(Kenkyū-buntansha) |
WADA Yasuaki 山口大学, 医学部・附属病院, 助教 (50448297)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 超音波医学 / 心不全 / 医用システム / 生理学 / 解析学 / 肥大型心筋症 |
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| Research Abstract |
METHODS : We obtained basal and apical LV short-axis views in 27 patients with non-obstructive HCM and 25 healthy volunteers. Eight equiangular points on the endo-myocardium at end-diastole were placed in each view, and the movements of these points were automatically tracked using a two-dimensional echocardiographic tissue tracking system. Time-LV radial shortening curves were obtained and averaged. The time intervals from the aortic valve closure to the point of the first 40% of peak lengthening (T_<40>) were measured in each view. RESULTS : The time difference in the T_<40> between the apex and base (Δ-T_<40>) in the HCM group was greater than that in the control group. There were good linear correlations between the Δ-T_<40> and the LV early diastolic echo-parameters and the LV mass index. CONCLUSIONS : Our results suggested that apical non-uniformity resulted in loss of active mechanical coordination of apex-to-basal lengthening, which could contribute to global LV diastolic impairment.
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Report
(4 results)
Research Products
(73 results)
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[Presentation] Loading stress echocardiography predicts deterioration of heart failure in patients with impaired relaxation transmitral pattern.2010
Author(s)
Yasuaki Wada, Kazuya Murata, Shinichi Okuda, Takeo Tanaka, Chikage Kihara, Kosuke Uchida, Hiroko Yoshino, Takehisa Susa, Kouichi Harada, Masunori Matsuzaki
Organizer
21^<st> Annual Scientific Sessions American Society of Echocardiography.
Place of Presentation
San Diego, USA
Year and Date
2010-06-13
Related Report
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[Presentation] Left ventricular Apical Rotation, but not Basal Rotation Contributes to Twist in Normal Subjects : Evaluation by a Novel Automated Three Dimensional wall Motion Tracking Technique.2009
Author(s)
Takeo Tanaka, Kazuya Murata, Chikage Kihara, Hiroko Yoshino, Yoshio Nose, Takehisa Susa, Shinichi Okuda, Yasuaki Wada, Masunori Matsuzaki
Organizer
82^<nd> Scientific Sessions American Heart Association
Place of Presentation
Orland, USA
Year and Date
2009-11-15
Related Report
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