| Project/Area Number |
20500421
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Kagawa University |
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Principal Investigator |
SENDA Shoichi Kagawa University, 医学部附属病院, 教授 (30145049)
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| Co-Investigator(Kenkyū-buntansha) |
MASUGATA Hisashi 香川大学, 医学部附属病院, 講師 (70263910)
GODA Fuminori 香川大学, 医学部附属病院, 准教授 (90294769)
山上 あゆむ 香川大学, 医学部附属病院, 医員 (30403786)
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| Research Collaborator |
YAMAGAMI Ayumu 公立福生病院, 内科, 医師 (30403786)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | メタボリックシンドローム / 心機能 / 血管機能 / 心血管危険因子 / 超音波 / 心血管機能 / 動脈硬化 |
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| Research Abstract |
We elucidated the cardiac structure and function of patients with metabolic syndrome by analyzing echocardiographic findings in patients with metabolic syndrome. The relative wall thickness, LV mass index, and LV ejection fraction demonstrated no difference between the two groups. However, the ratio of E to A (E/A) of transmitral flow demonstrated significant difference between the metabolic syndrome and the non-metabolic syndrome groups. Patients with metabolic syndrome demonstrated LV diastolic dysfunction even if they have neither LV hypertrophy nor systolic dysfunction. Moreover, we elucidated the LV function in patients with hypertension (HT) and diabetes (DM) in various age strata. The strain and strain rate assessed by tissue Doppler echocardiography (TDE) in the HT group and DM group showed lower values than those in the healthy control subjects in each age stratum. Furthermore, the strain and strain rate in the HT+DM group showed the lowest values among all four groups in each age stratum. Although HT or DM affected normal age-related changes in LV function, the coexistence of HT and DM had a more harmful effect on the normal age-related changes than HT alone or DM alone.
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