Impacts of Ultrasound Exposure to Adipose Tissue in Metabolic Syndrome

• Project/Area Number: 20500422
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: Kagawa University
• Principal Investigator: OHMORI Koji 香川大学, 医学部, 准教授 (00263913)
• Co-Investigator(Kenkyū-buntansha): KOHNO Masakazu 香川大学, 医学部, 教授 (20153489) ; NOMA Takahisa 香川大学, 医学部附属病院, 講師 (20363202) ; MURAO Koji 香川大学, 医学部, 教授 (20291982) ; SHINOMIYA Kaori 香川大学, 医学部附属病院, 助教 (70380160) ; ISHIHARA Yasuhiro 香川大学, 医学部附属病院, 助教 (80532689) ; HASAN Ul arif 香川大学, 医学部, 外国人研究者 (00570368) ; YOSHIDA Junji 香川大学, 医学部附属病院, 助教 (50448370) ; YUKIIRI Kazushi 香川大学, 医学部附属病院, 講師 (30346647)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 脂肪前駆細胞 / スタチン / ピオグリタゾン / アディポサイトカイン / 細胞周期 / アンチエイジング / 肥満 / インスリン抵抗性 / サイクリン依存性キナーゼ / 脂肪細胞 / 超音波 / ピタバスタチン / 肥満モデルマウス / アディポネクチン / アディポカイン / 細胞培養

Research Abstract

Because ultrasound radiation alone did not ameliorate adipocyte dysfunction, we investigated the molecular target of frequently used drugs as the adjunct therapy. Pitavastatin enhanced adipocyte proliferation/ maturation, increased small adipocyte count, preserved adiponectin level, and improved insulin resistance ; pioglitazone suppressed a cell-cycle inhibiting factor and increased adipocyte count. Thus, therapeutic ultrasound with the adjunctive drugs would include cell-cycle inhibitors.

Research Products

• [Journal Article] Pioglitazone promotes preadipocyte proliferation by downregulating p16(Ink4a) (2011)
  • Author(s): Hasan AU, Ohmori K, Hashimoto T, Kamitori K, Hirata Y, Ishihara Y, Okamoto N, Noma T, Kosaka H, Tokuda M, Kohno M
  • Journal Title: Biochem Biophys Res Commun Volume: 411(2) Pages: 375-80
  • Peer Reviewed
• [Journal Article] Lipid peroxidation-induced VEGF expression in the skin of KKA(y) obese mice. (2011)
  • Author(s): 中井浩三
  • Journal Title: Exp Dermatol Volume: (掲載確定)
  • Peer Reviewed
• [Journal Article] Beneficial direct adipotropic actions of pitavastatin in vitro and their manifestations in obese mice (2010)
  • Author(s): Ishihara Y, Ohmori K, Mizukawa M, Hasan AU, Noma T, Kohno M
  • Journal Title: Atherosclerosis Volume: 212(1) Pages: 131-8
  • Peer Reviewed
• [Journal Article] Beneficial direct adipotropic actions of pitavastatin in vitro and their manifestations in obese mice. (2010)
  • Author(s): 石原靖大
  • Journal Title: Atherosclerosis Volume: 212 Pages: 131-138
  • Peer Reviewed
• [Presentation] PPAR-gamma enhances adipogenesis by down-regulating a cell cycle inhibitor, p16INK4a, in adipocytes (2010)
  • Author(s): 野間貴久
  • Organizer: ESC (European Society of Cardiology) Congress2010.
  • Place of Presentation: スウェーデン ストックホルム
  • Year and Date: 2010-08-30
• [Presentation] Pioglitazone exerts proliferatory and anti-aging actions in adipocytes by suppressing Ink4a/Arf locus transcripts. (2010)
  • Author(s): アリフハサン
  • Organizer: The 3^<rd> Joint Symposium between Chiang Mai University and Kagawa University
  • Place of Presentation: タイ チェンマイチェンマイ大学(招待講演)
  • Year and Date: 2010-08-24
• [Presentation] Beneficial Direct adipotropic actions of pitavastatin in vitro and their manifestations in a mouse model of obesity (2010)
  • Author(s): Ishihara Y(代表), Ohmori K, Hasan U A, Noma T, Iwado Y, Murakami K, Namba T, Kitaizumi K, Okamoto N, Kohno M
  • Organizer: 第42回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 岐阜市
  • Year and Date: 2010-07-15
• [Presentation] Pioglitazone links PPAR・dependent adipogenesis pathways to tumor suppressor p53 pathways through p16 (2010)
  • Author(s): Hasan, A. U(代表), Ohmori K, Hashimoto T, Kamitori K, Hirata Y, Ishihara Y, Okamoto N, Noma T, Tokuda M, and Kohno M
  • Organizer: The 3^<rd> Joint Symposium between Chiang Mai University and Kagawa University
  • Place of Presentation: タイ国、チェンマイ市
• [Presentation] PPAR-γenhances adipogenesis by down-regulating a cell cycle inhibitor, p16INK4a, in adipocytes (2010)
  • Author(s): Hasan, A. U.(代表), Ohmori K, Hashimoto T, Kamitori K, Hirata Y, Ishihara Y, Okamoto N, Noma T, Tokuda M, and Kohno M
  • Organizer: Annual Meeting of European Society of Cardiology
  • Place of Presentation: スウェーデン国、ストックホルム市
• [Presentation] 脂肪細胞に対するピタバスタチンの効果について (2008)
  • Author(s): 石原靖大, 大森浩二, 吉田潤史, 野間貴久, 河野雅和ら
  • Organizer: 2nd Kagawa Life Style Disease Seminar
  • Place of Presentation: 高松市
  • Year and Date: 2008-10-20