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Development of an image reconstruction algorithm for ultra high spatial-resolution and quantitative SPECT in a selected small region

Research Project

Project/Area Number 20500435
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

ZENIYA Tsutomu  National Cardiovascular Center Research Institute, 画像診断医学部, 室長 (50443487)

Co-Investigator(Renkei-kenkyūsha) IIDA Hidehiro  独立行政法人国立循環器病研究センター, 画像診断医学部, 部長 (30322720)
WATABE Hiroshi  大阪大学, 医学系研究科, 准教授 (40280820)
HAYASHI Takuya  独立行政法人理化学研究所, 分子イメージング科学研究センター, 副チームリーダー (50372115)
KOSHINO Kazuhiro  独立行政法人国立循環器病研究センター, 画像診断医学部, 研究員 (90393206)
TERAMOTO Noboru  大阪大学, 医学系研究科, 特任研究員 (40372114)
KUDO Hiroyuki  筑波大学, システム情報工学研究科, 教授 (60221933)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords画像診断 / 核医学 / SPECT / 画像再構成アルゴリズム / 分子機能定量 / 高解像度 / トランケーション / シミュレーション / 生体機能 / 画像 / アルゴリズム / 定量 / コリメータ / ピンホール
Research Abstract

We developed an image reconstruction algorithm for SPECT system to quantitatively image molecular functions in a selected small region with ultra high spatial resolution. In addition, for imaging with high sensitivity, we applied this algorithm to the system consisting of multiple detectors with multi-pinholes. The computer simulation showed that the combination of this high sensitive system and truncation compensated reconstruction algorithm can provide high-resolution image with high S/N ratio and no effect of truncation in a small region of human brain.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2010 2009 2008

All Journal Article (11 results) (of which Peer Reviewed: 4 results) Presentation (14 results)

  • [Journal Article] Multicenter evaluation of a standard protocol for rest and acetazolamide cerebral blood flow assessment using a quantitative SPECT reconstruction program and split-dose 123I-iodoamphetamine.2010

    • Author(s)
      Iida H, Nakagawara J, Hayashida K, Fukushima K, Watabe H, Koshino K, Zeniya T, Eberl S.
    • Journal Title

      J Nucl Med Vol.52、No.10

      Pages: 1624-1631

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] High resolution brain imaging with combined parallel-hole and pinhole collimation2010

    • Author(s)
      Huang Q, Zeniya T, Kudo H, Iida H, Gullberg GT.
    • Journal Title

      2010 IEEE Nuclear Science Symposium Conference Record

      Pages: 3145-3148

    • Related Report
      2010 Final Research Report
  • [Journal Article] 頭部SPECTにおけるコリメータ開口補正およびモンテカルロ法に基づく散乱線補正を用いた画像再構成法の定量精度評価.2010

    • Author(s)
      崎本智則、銭谷勉、石田健二、渡部浩司、平野祥之、Antti Sohlberg、湊小太郎、飯田秀博
    • Journal Title

      Med Imag Tech Vol.28、No.2

      Pages: 135-144

    • NAID

      10026248551

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multicenter evaluation of a standardized protocol for rest and acetazola mide cerebral blood flow assessment using a quantitative SPECT recons truction program and split-dose 123I-iodoamphetamine.2010

    • Author(s)
      Iida H, Zeniya T, et al.
    • Journal Title

      Journal of Nuclear Medicine

      Volume: 51 Pages: 1624-1631

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High resolution brain imaging with combined parallel-hole and pinhole collimation.2010

    • Author(s)
      Huang Q, Zeniya T, et al.
    • Journal Title

      2010 IEEE Nuclear Science Symposium Conference Record

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 頭部SPECTにおけるコリメータ開口補正およびモンテカルロ法に基づく散乱線補正を用いた画像再構成法の定量精度評価2010

    • Author(s)
      崎本智則、銭谷勉, 他
    • Journal Title

      日本医用画像工学会誌Medical Imaging Technology 28巻

      Pages: 135-144

    • NAID

      10026248551

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conceptual design of high resolution and quantitative SPECT system for imaging a selected small ROI of human brain.2009

    • Author(s)
      Zeniya T, Hirano Y, Sakimoto T, Ishida K, Watabe H, Teramoto N, Kudo H, Minato K, Hatazawa J, Iida H
    • Journal Title

      2009 IEEE Nuclear Science Symposium Conference Record

      Pages: 3484-3486

    • Related Report
      2010 Final Research Report
  • [Journal Article] 小動物の高解像度イメージング2009

    • Author(s)
      銭谷勉、飯田秀博
    • Journal Title

      Isotope News No.659

      Pages: 109-110

    • Related Report
      2010 Final Research Report
  • [Journal Article] 小動物の高解像度SPECTイメージング2009

    • Author(s)
      銭谷勉
    • Journal Title

      Isotope News 659

      Pages: 7-9

    • NAID

      10025107610

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 高解像度定量ピンホールSPECTイメージング-小動物から臨床へ-2008

    • Author(s)
      銭谷勉、渡部浩司、工藤博幸、飯田秀博
    • Journal Title

      映像情報メディカル Vol.40、No.13

      Pages: 1210-1215

    • Related Report
      2010 Final Research Report
  • [Journal Article] 高解像度定量ピンホールSPECTイメージング-小動物から臨床へ-2008

    • Author(s)
      銭谷勉
    • Journal Title

      映像情報メディカル 40

      Pages: 1210-1215

    • Related Report
      2008 Annual Research Report
  • [Presentation] 高解像度定量画像再構成法のI-123対応とファントム実験による定量精度評価2010

    • Author(s)
      銭谷勉
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      大宮
    • Year and Date
      2010-11-11
    • Related Report
      2010 Final Research Report
  • [Presentation] 高解像度定量画像再構成法のI-123対応とファントム実験による定量精度評価2010

    • Author(s)
      銭谷勉, 他
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      大宮ソニックシティ(埼玉)
    • Year and Date
      2010-11-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Evaluation of a new image reconstruction for high resolution and quantification in I-123 brain SPECT2010

    • Author(s)
      銭谷勉
    • Organizer
      Society of Nuclear Medicine's 57th Annual Meeting
    • Place of Presentation
      Salt Lake City(USA)
    • Year and Date
      2010-06-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Evaluation of a new image reconstruction for high resolution and quant ification in I-123 brain SPECT2010

    • Author(s)
      Zeniya T, et al.
    • Organizer
      Society of Nuclear Medicine's 57th Annual Meeting
    • Place of Presentation
      Salt Palace Convention Center(Salt Lake City, USA)
    • Year and Date
      2010-06-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Conceptual design of high resolution and quantitative SPECT system for imaging a selected small ROI of human brain2009

    • Author(s)
      銭谷勉
    • Organizer
      2009 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Place of Presentation
      Orlando(USA)
    • Year and Date
      2009-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Conceptual design of high resolution and quantitative SPECT system for imaging a selected small ROI of human brain2009

    • Author(s)
      Zeniya T, et al.
    • Organizer
      2009 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Place of Presentation
      Hilton hotel(Orlando, USA)
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 頭部用局所高解像度定量SPECT装置の開発2009

    • Author(s)
      銭谷勉
    • Organizer
      第49回日本核医学学術総会
    • Place of Presentation
      旭川
    • Year and Date
      2009-10-01
    • Related Report
      2010 Final Research Report
  • [Presentation] 頭部用局所高解像度定量SPECT装置の開発2009

    • Author(s)
      銭谷勉, 他
    • Organizer
      第49回日本核医学会学術総会
    • Place of Presentation
      旭川グランドホテル(北海道)
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] RI分子標的診断を可能にする高解像度SPECT撮像装置の開発2009

    • Author(s)
      銭谷勉
    • Organizer
      第48回日本生体医工学会大会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-25
    • Related Report
      2010 Final Research Report
  • [Presentation] RI分子標的診断を可能にする高解像度SPECT撮像装置の開発2009

    • Author(s)
      銭谷勉, 他
    • Organizer
      第48回日本生体医工学会大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小視野検出器を利用した臨床用局所高解像度定量SPECTの検討2008

    • Author(s)
      銭谷勉
    • Organizer
      第48回日本核医学学術総会
    • Place of Presentation
      千葉
    • Year and Date
      2008-10-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 小視野高解像度検出器と大視野低解像度検出器を組み合わせた局所高解像度定量SPECTの検討2008

    • Author(s)
      銭谷勉
    • Organizer
      第48回日本核医学学術総会
    • Place of Presentation
      千葉
    • Year and Date
      2008-10-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 小視野検出器を利用した臨床用局所高解像度定量SPECTの検討2008

    • Author(s)
      銭谷勉
    • Organizer
      日本核医学会学術総会
    • Place of Presentation
      千葉幕張メッセ
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 小視野高解像度検出器と大視野低解像度検出器を組み合わせた局所高解像度定量SPECTの検討2008

    • Author(s)
      銭谷勉
    • Organizer
      日本核医学会学術総会
    • Place of Presentation
      千葉幕張メッセ
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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