| Project/Area Number |
20500437
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
|
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| Research Institution | Tohoku University |
|---|
Principal Investigator |
ITO Osamu Tohoku University, 大学院・医学系研究科, 准教授 (00361072)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
KANAZAWA Masayuki 東北大学, 大学院・医学系研究科, 非常勤講師 (60282050)
KOHZUKI Masahiro 東北大学, 大学院・医学系研究科, 教授 (70234698)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
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| Keywords | リハビリテーション医学 / リハビリテーション / 酸化ストレス / 循環器・高血圧 / 脂質 / 動物 |
|---|
| Research Abstract |
H_2O_2, among reactive oxygen species, upregulates the nitric oxide (NO) production and NO synthase (NOS) expression and controls glomerular filtration rate (GFR) in the kidney of spontaneously hypertensive rats (SHR). Exercise training (EX) upregulates the NO production and NOS expression in the kidney of SHR, and H_2O_2mediates these effects of EX. Superoxide dismutase mimetic, tempol enhances these effects of EX in SHR, such as antihypertension, increase of GFR and upregulation of the NO production and NOS expression in the kidney.
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