Neuromuscular junction remodeling : a study of molecular mechanism
| Project/Area Number |
20500443
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kanazawa University |
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Principal Investigator |
MIAKI Hiroichi (2010) Kanazawa University, 保健学系, 准教授 (60251964)
洲崎 俊男 (2009) Kanazawa University, 保健学系, 准教授 (40171194)
立野 勝彦 (2008) Kanazawa University, 保健学系, 教授 (40092788)
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| Co-Investigator(Kenkyū-buntansha) |
TACHINO Katsuhiko 金沢大学, 保健学系, 教授 (40092788)
SUSAKI Toshio 金沢大学, 保健学系, 准教授 (40171194)
TANAKA Shoji 金沢大学, 保健学系, 助教 (70422657)
INAOKA Pureiadesu Chiharu 金沢大学, 保健学系, 助教 (90507386)
三秋 泰一 金沢大学, 保健学系, 准教授 (60251964)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | リハビリテーション / 再生 / 脱神経筋 / リモデリング / 神経再生 |
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| Research Abstract |
This scientific research in rehabilitation medicine was performed in order to clarify the pathological changes and repair mechanism of neuromuscular junction after tibial nerve denervation. The factors related to the maintenance and repair of neuromuscular junction function were studied by immunohistological observation and molecular biology analysis. Our results indicated that a factor relevant to muscle repair and a factor participant in neuromuscular junction maturity were increased. Further investigation is needed to ascertain the correlation between those factors.
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Report
(4 results)
Research Products
(2 results)
