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Neuromuscular junction remodeling : a study of molecular mechanism

Research Project

Project/Area Number 20500443
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKanazawa University

Principal Investigator

MIAKI Hiroichi (2010)  Kanazawa University, 保健学系, 准教授 (60251964)

洲崎 俊男 (2009)  Kanazawa University, 保健学系, 准教授 (40171194)

立野 勝彦 (2008)  Kanazawa University, 保健学系, 教授 (40092788)

Co-Investigator(Kenkyū-buntansha) TACHINO Katsuhiko  金沢大学, 保健学系, 教授 (40092788)
SUSAKI Toshio  金沢大学, 保健学系, 准教授 (40171194)
TANAKA Shoji  金沢大学, 保健学系, 助教 (70422657)
INAOKA Pureiadesu Chiharu  金沢大学, 保健学系, 助教 (90507386)
三秋 泰一  金沢大学, 保健学系, 准教授 (60251964)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsリハビリテーション / 再生 / 脱神経筋 / リモデリング / 神経再生
Research Abstract

This scientific research in rehabilitation medicine was performed in order to clarify the pathological changes and repair mechanism of neuromuscular junction after tibial nerve denervation. The factors related to the maintenance and repair of neuromuscular junction function were studied by immunohistological observation and molecular biology analysis. Our results indicated that a factor relevant to muscle repair and a factor participant in neuromuscular junction maturity were increased. Further investigation is needed to ascertain the correlation between those factors.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (2 results)

All 2009 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Remarks (1 results)

  • [Journal Article] Molecular biological changes in reloaded skeletal muscles after rat hindlimb suspension2009

    • Author(s)
      Tsuji, K., Inaoka, PT., Tanaka, S., Tachio, K.
    • Journal Title

      21

      Pages: 221-226

    • NAID

      10025401759

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Remarks] ホームページ等

    • URL

      http://phys_ther.w3.kanazawa-u.ac.jp/

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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