Cortical neurons whose axons spared from a spinal cord hemisection : how do they concern motor recovery?

• Project/Area Number: 20500457
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Prefectural University of Hiroshima
• Principal Investigator: TAKEMOTO Hidenori Prefectural University of Hiroshima, 保健福祉学部, 助教 (10453218)
• Co-Investigator(Renkei-kenkyūsha): KANEMURA Naohiko 埼玉県立大学, 保健医療福祉学部, 講師 (20379895) ; TOBIMATSU Yoshiko 国立障害者リハビリテーションセンター(研究所), 義肢装具技術研究部, 部長 (20172174)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 脊髄半切 / 運動回復 / 錐体路ニューロン / 軸索の可塑性 / 神経棘の可塑性

Research Abstract

The aim of this study was to clarify changes in dendritic spines of cortical neurons which form sprouting in denervated area following a spinal cord hemisection. To detect neurons which form sprouting, it turned out that retrograde tracer should be injected into denervated area immediately after hemisection, and that tracers which are transported within neurites via specific membrane molecules should be used. On the other hand, analyses for changes in dendritic spines of cortical neurons which form sprouting after a spinal cord hemisection are under continuation now.

Research Products

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