The effects of therapeutic exercise on the endothelial cell, monocyte and platelet functions and atherosclerosis in metabolic syndrome

• Project/Area Number: 20500462
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Saitama Medical University
• Principal Investigator: KURABAYASHI Hitoshi Saitama Medical University, 医学部, 准教授 (70192036)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 運動療法 / 脳梗塞 / 動脈硬化 / メタボリック症候群 / 血小板活性化 / 線溶機能 / 血管内皮障害 / 炎症性サイトカイン / リハビリテーション / 脳卒中 / 血小板

Research Abstract

Atherosclerosis causes platelet activation, endothelial dysfunction and coagulation fibrinolytic disorder, resulting in thrombosis. The aim of this study is to determine the effect of continuing exercise on the prevention of atherosclerosis. Therapeutic exercise decreased endothelial dysfunction, platelet activation and coagulation activity but increased fibrinolytic capacity in patients with cerebral infarction. It is suggested that therapeutic exercise has a role in secondary prevention for cerebral infarction.

Research Products

• [Journal Article] Platelet activation is caused not by aging but by atherosclerosis. (2010)
  • Author(s): Kurabayashi H, Kubota K, Hishinuma A, Majima M
  • Journal Title: Arch Gerontol Geriat 51 Pages: 205-208
  • Peer Reviewed
• [Journal Article] Platelet activation is caused not by aging but by atherosclerosis (2010)
  • Author(s): Kurabayashi H
  • Journal Title: Archives of Gerontology and Geriatrics Volume: 51 Pages: 205-208
  • Peer Reviewed
• [Journal Article] Successful treatment of pulmonary aspiration due to brain stem infarction by using cough exercise based on swallowing scintigraphy : preliminary observations. (2009)
  • Author(s): Kanai N, Kurabayashi H, Nakamata N, Yamamoto E, Hishinuma A, Suzuki E, Majima M
  • Journal Title: Dysphagia 24 Pages: 434-437
  • Peer Reviewed
• [Journal Article] Is insulin resistance related to recurrence of stroke or incident of ischemic heart disease in patients with stroke? Preliminary report. (2009)
  • Author(s): Hishinuma A, Majima M, Kurabayashi H
  • Journal Title: J Stroke Cerebrovasc Dis 18 Pages: 294-297
  • Peer Reviewed
• [Journal Article] リハビリテーションによる高齢脳卒中患者の機能的自立度FIM の解析 (2009)
  • Author(s): 倉林均、菱沼亜紀子、内田龍制、牧田茂、間嶋満
  • Journal Title: 埼玉医誌 44 Pages: 311-316
• [Journal Article] Successful treatment of pulmonary aspiration due to brain stem infarction by using cough exercise based on swallowing scintigraphy (2009)
  • Author(s): Kanai N
  • Journal Title: Dysphagia 24 Pages: 434-437
  • Peer Reviewed
• [Journal Article] Is insulin related to recurrence of stroke or incident of ischemic heart disease in patients with stroke? (2009)
  • Author(s): Hishinuma A
  • Journal Title: Journal of Stroke and Cerebrovascular Diseases 18 Pages: 294-297
  • Peer Reviewed
• [Journal Article] Insulin resistance in patients with stroke is related to visceral fat obesity and adipocytokines. (2008)
  • Author(s): Hishinuma A, Majima M, Kurabayashi H
  • Journal Title: J Stroke Cerebrovasc Dis 17 Pages: 175-180
  • Peer Reviewed
• [Journal Article] 生活習慣病における血管内皮・単球・血小板の機能と動脈硬化進展の機序の解明 (2008)
  • Author(s): 倉林均
  • Journal Title: 埼医大雑誌 35 Pages: 39-41
• [Journal Article] Insulin resistance in patients with stroke is related to visceral fat obesity and adipocytokines (2008)
  • Author(s): Hishinuma A
  • Journal Title: Journal of Stroke and Cerebrovascular Diseases 17 Pages: 175-180
  • Peer Reviewed
• [Presentation] 脳卒中高齢者のリハビリテーションによる機能的自立度FIM の改善(続報) (2010)
  • Author(s): 倉林均
  • Organizer: 第52回日本老年医学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-25
• [Presentation] Special lecture : Magic and charm of hot-spring therapy-From traditional medicine to modern medical science- (2010)
  • Author(s): Kurabayashi H
  • Organizer: The 21st Japan China Korea Joint Conference on Occupational Health
  • Place of Presentation: Utsunomiya, Japan
  • Year and Date: 2010-06-12
• [Presentation] 脳梗塞の運動療法による抗血栓効果の解析 (2010)
  • Author(s): 倉林均
  • Organizer: 第47回日本リハビリテーション医学会学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2010-05-20
• [Presentation] Special lecture. Magic and charm of hot-spring therapy.-From traditional medicine to modern medical science- (2010)
  • Author(s): 倉林均
  • Organizer: The 21st Japan China Korea Joint Conference on Occupational Health.
  • Place of Presentation: Utsunomiya
  • Year and Date: 2010-01-12
• [Presentation] 高グリセリド血症を有する脳卒中患者で、糖尿病の既往歴のない患者における耐糖能障害の検討 (2009)
  • Author(s): 間嶋満
  • Organizer: 第43回日本リハビリテーション医学会関東地方会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-12
• [Presentation] 高齢脳梗塞のリハビリテーション中の血管内皮、凝固・線溶、血小板マーカーの変動 (2009)
  • Author(s): 倉林均
  • Organizer: 第51回日本老年医学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2009-06-19
• [Presentation] 高齢脳梗塞のリハビリテーション中の血管内皮、凝固・線溶、血小板マーカーの変動 (2009)
  • Author(s): 倉林均
  • Organizer: 日本老年医学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-06-19
• [Presentation] 脳卒中患者の内臓脂肪とアディポサイトカインの改善に対する歩行の効果 (2009)
  • Author(s): 菱沼亜紀子
  • Organizer: 第46回日本リハビリテーション医学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2009-06-05
• [Presentation] 嚥下シンチグラフィー評価と咳嗽練習により誤嚥が改善したワレンベルグ症候群の1例 (2009)
  • Author(s): 倉林均
  • Organizer: 第46回日本リハビリテーション医学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2009-06-04
• [Presentation] 血管内皮、血小板、凝固線溶系の指標による脳卒中の機能的予後の予測 (2009)
  • Author(s): 倉林均
  • Organizer: 第46回埼玉県医学会総会
  • Place of Presentation: さいたま
  • Year and Date: 2009-02-22
• [Presentation] Chronic kidney disease (CKD) を合併した脳卒中患者におけるインスリン抵抗性改善のための運動は、CKD のどのstage まで許容されるか (2008)
  • Author(s): 間嶋満
  • Organizer: 第41回日本リハビリテーション医学会関東地方会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-12-13
• [Presentation] 単球、CRP、DD、ELAM と脳卒中の機能予後との関連 (2008)
  • Author(s): 倉林均
  • Organizer: 第50回日本老年医学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2008-06-19
• [Presentation] 単球, CRP, ELAMと脳卒中の機能的予後との関連 (2008)
  • Author(s): 倉林均
  • Organizer: 日本老年医学会学術集会
  • Place of Presentation: 千葉県幕張
  • Year and Date: 2008-06-19
• [Presentation] リハビリテーションによる高齢脳卒中患者の機能的自立度FIM の解析 (2008)
  • Author(s): 倉林均
  • Organizer: 第105回日本内科学会講演会
  • Place of Presentation: 東京
  • Year and Date: 2008-04-13
• [Book] NHKテレビテキスト「きょうの健康」入浴事故を防ぐ! (2008)
  • Author(s): 倉林 均
  • Total Pages: 4
  • Publisher: 日本放送出版協会
• [Remarks] ホームページ等
  • URL: http://www.saitama-med.ac.jp/uinfo/rehabilitation/http://www013.upp.so-net.ne.jp/balneology-res/
• [Remarks]
  • URL: http://www.saitama-med.ac.jp/uinfo/rehabilitation/
• [Remarks]
  • URL: http://www013.upp.so-net.ne.jp/balneology-res/