Mechanisms on muscle atrophy by long-term bed rest with or without rehabilitation on in old age
| Project/Area Number |
20500470
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
YAMAUCHI Hideki Jikei University School of Medicine, 医学部, 講師 (60220224)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 加齢 / 安静臥床 / 筋萎縮 / 筋変性 / リハビリテーション / 速筋化 / 高齢期 / 腓腹筋 / 赤色部 / 白色部 / 間欠的再荷重 / タンパク質発現 / 足底筋 / ミオシン重鎖分子種 / クエン酸合成酵素 / 萎縮 / 脂肪酸β酸化酵素 / PGC1α / HSP25 / 抵抗運動 / ストレスタンパク質 / ミオスタチン / Akt |
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| Research Abstract |
For establishment of effective exercise conditions to reduce muscle atrophy with shifts to the faster characteristics by the physical inactivity, we examined the effects of continuous exercise with low load and intermittent exercise with high load that carried out during bed rest in young, middle, and old age. As a result, in both fast- and slow-twitch muscle, the muscle atrophy by bed rest became remarkable, but shifts to the faster characteristics became less with aging. Inhibitory effects was similar between both exercise regimens in the slow-twitch muscle in all aging stages, but reduction effect on an muscle atrophy was higher with intermittent exercise with high load than continuous exercise with low load in the fast-twitch muscle.
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Report
(4 results)
Research Products
(7 results)
