| Project/Area Number |
20500476
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kibi International University |
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Principal Investigator |
HIRAGAMI Fukumi Kibi International University, 保健科学部, 教授 (60278976)
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| Co-Investigator(Kenkyū-buntansha) |
KANO Yoshio 吉備国際大学, 保健科学部, 教授 (70116200)
AKIYAMA Junichi 吉備国際大学, 保健科学部, 准教授 (00309600)
MOTODA Hirotoshi 吉備国際大学, 保健科学部, 講師 (30278999)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 正常ヒト線維芽細胞 / 温熱刺激 / 三次元様増殖 / p38 MAPK / Hsp27 |
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| Research Abstract |
The aim of this study was to elucidate the cellular mechanisms underlying the therapeutic effects of heat. To that end, we studied the optimal heat conditions for enhancement of pressed silk-mediated 3D-like proliferation of normal human dermal fibroblasts as well as the responses to heat shock of cells and intracellular signaling pathways. We observed changes in the 3D-like proliferation pattern induced by heat treatment at 43℃ for 10 min and found that activation of p38 MAPK and Hsp27 by the same heat treatment is associated with 3D-like cell proliferation.
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