Effects of prolyl hydroxylase inhibitor treatment on oxygen sensing mechanism in skeletal muscles

• Project/Area Number: 20500571
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Hokkaido University of Education
• Principal Investigator: SUZUKI Junichi Hokkaido University of Education, 教育学部, 准教授 (80261379)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: スポーツ生理学 / 運動生理学 / 酸素センシング機構 / 生体酸素センサー / 血管新生 / 低酸素適応 / 毛細血管

Research Abstract

Recently a family of O2-dependent prolyl hydroxylase domain-containing enzymes has been identified as a cellular oxygen sensing mechanism. Reduced prolyl hydroxylase activity facilitates an accumulation of hypoxia-inducible factor (HIF-1alpha). This study was designed to examine the effects of prolyl hydroxylase inhibitor, supplementation on muscle oxygen sensing mechanism. The present results suggest that prolyl hydroxylase inhibitor facilitates capillary angiogenesis and glycolytic enzyme activity via HIF-1alpha upregulation in hind-leg muscles.

Research Products

• [Journal Article] Effects of prolyl hydroxylase inhibitor on fiber type composition and metabolic enzyme activities in rat soleus muscle. (2011)
  • Author(s): SUZUKI Junichi
  • Journal Title: 北海道教育大学紀要(自然科学編) 第61巻 Pages: 7-11
  • NAID: 110008428951
• [Journal Article] Effects of Prolyl Hydroxylase Inhibitor on Fiber Type Composition and Metabolic Enzyme activities in Rat Soleus Muscle. (2011)
  • Author(s): SUZUKI Junichi
  • Journal Title: 北海道教育大学紀要(自然科学編) Volume: 61 Pages: 7-11
  • NAID: 110008428951
• [Presentation] Prolyl hydroxylase抑制剤の投与は運動依存性毛細血管新生を促進する. (2010)
  • Author(s): 鈴木淳一
  • Organizer: 第18回大会
  • Place of Presentation: 鹿児島
  • Year and Date: 2010-08-01
• [Presentation] Prolyl hydroxylase抑制剤の投与は運動依存性毛細血管新生を促進する (2010)
  • Author(s): 鈴木淳一
  • Organizer: 日本運動生理学会第18回大会
  • Place of Presentation: 鹿児島大学
  • Year and Date: 2010-08-01
• [Presentation] Prolyl hydroxylase抑制剤の投与が骨格筋の運動依存性毛細血管新生に及ぼす影響 (2009)
  • Author(s): 鈴木淳一
  • Organizer: 日本運動生理学会
  • Place of Presentation: 慈恵会医科大学
  • Year and Date: 2009-07-26
• [Presentation] Prolyl hydroxylase抑制剤の投与が骨格筋の運動依存 性毛細血管新生に及ぼす影響 (2009)
  • Author(s): 鈴木淳一
  • Organizer: 日本運動生理学会 第17回大会
  • Place of Presentation: 東京
  • Year and Date: 2009-07-25
• [Presentation] Prolyl hydroxylase抑制剤の投与が骨格筋の毛細血管新生と代謝酵素活性に及ぼす影響 (2008)
  • Author(s): 鈴木淳一
  • Organizer: 日本運動生理学会
  • Place of Presentation: 帝塚山大学
  • Year and Date: 2008-08-03
• [Presentation] Prolyl hydroxylase抑制剤の投与が骨格筋の毛細血管 新生と代謝酵素活性に及ぼ す影響 (2008)
  • Author(s): 鈴木淳一
  • Organizer: 日本運動生理学会第16回大会
  • Place of Presentation: 奈良
  • Year and Date: 2008-08-02