Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Research Abstract |
Using senescent mice (24-month-old), I investigated the adaptive changes in SRF-linked molecule in skeletal muscle. In aged mice, we observed the mardked reductions in the amount of SRF (in cytosol fraction) and MRTF-A (nuclear fraction) proteins in quadriceps muscle. The expression levels of STARS, a possible SRF-upstream mediator, were also decreased in the muscle. Although voluntary exercise attenuated the sarcopenic symptom, there is no significant change in SRF-linked molecules.
|