Does habitual voluntary exercise attenuate sarcopenic symptom?

• Project/Area Number: 20500575
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Toyohashi University of Technology
• Principal Investigator: SAKUMA Kunihiro Toyohashi University of Technology, 総合教育院, 准教授 (60291176)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 加齢 / 骨格筋 / 運動 / 筋肥大 / サルコペニア / SRF / サルコペニア(加齢性筋肉減弱症) / 筋萎縮

Research Abstract

Using senescent mice (24-month-old), I investigated the adaptive changes in SRF-linked molecule in skeletal muscle. In aged mice, we observed the mardked reductions in the amount of SRF (in cytosol fraction) and MRTF-A (nuclear fraction) proteins in quadriceps muscle. The expression levels of STARS, a possible SRF-upstream mediator, were also decreased in the muscle. Although voluntary exercise attenuated the sarcopenic symptom, there is no significant change in SRF-linked molecules.

Research Products

• [Journal Article] Oxidative stress and skeletal muscle dysfunction with aging. (2011)
  • Author(s): Aoi W, Sakuma K
  • Journal Title: Curr Aging Sci in press
  • Peer Reviewed
• [Journal Article] Yamaguchi A : The functional role of calcineurin in hypertrophy, regeneration, and disorders of skeletal muscle. (2010)
  • Author(s): Sakuma K
  • Journal Title: J Biomed Biotechnol 2010 : Article ID 721219 Pages: 8-8
  • Peer Reviewed
• [Journal Article] Yamaguchi A : Molecular mechanisms in aging and current strategies to counteract sarcopenia. (2010)
  • Author(s): Sakuma K
  • Journal Title: Curr Aging Sci 3 Pages: 90-101
  • Peer Reviewed
• [Journal Article] Muscle contractile activity regulates Sirt3 protein expression in rat skeletal muscles. (2010)
  • Author(s): Hokari F, Kawasaki E, Sakai A, Koshinaka K, Sakuma K, Kawanaka K
  • Journal Title: J Appl Physiol 109 Pages: 332-340
  • Peer Reviewed
• [Journal Article] Expression profile of Notch-1 in mechanically overloaded plantaris muscle of mice. (2010)
  • Author(s): Akiho M, Nakashima H, Sakata M, Yamasa Y, Yamaguchi A, Sakuma K
  • Journal Title: Life Sci 86 Pages: 59-65
  • Peer Reviewed
• [Journal Article] The functional role of calcineurin in hypertrophy, regeneration, and disorders of skeletal muscle. (2010)
  • Author(s): Sakuma K, Yamaguchi A
  • Journal Title: Journal of Biomedicine and Biotechnology Volume: 2010 Pages: 2010-8
  • Peer Reviewed
• [Journal Article] Molecular mechanisms in aging and current strategies to counteract sarcopenia. (2010)
  • Author(s): Sakuma K, Yamaguchi A
  • Journal Title: Current Aging Science Volume: 3 Pages: 90-101
  • Peer Reviewed
• [Journal Article] Muscle contractile activity regulates Sirt3 protein expression in rat skeletal muscles. (2010)
  • Author(s): Hokari F, Kawasaki E, Sakai A, Koshinaka K, Sakuma K, Kawanaka K
  • Journal Title: Journal of Applied Physiology Volume: 109 Pages: 332-340
  • Peer Reviewed
• [Journal Article] Expression profile of Notch-1 in mechanically overloaded plantaris muscle of mice. (2010)
  • Author(s): Akiho M.nakashima H, Sakata M, Yamasa Y, Yamaguchi A, Sakuma K
  • Journal Title: Life Sciences Volume: 86 Pages: 59-65
  • Peer Reviewed
• [Journal Article] The adaptive responses in several mediators linked with hypertrophy and atrophy of skeletal muscle after lower limb unloading in humans. (2009)
  • Author(s): Sakuma K, Watanabe K, Hotta N, Koike T, Ishida K, Katayama K, Akima H
  • Journal Title: Acta Physiol(Oxf) 197 Pages: 151-159
  • Peer Reviewed
• [Journal Article] The expression pattern of PKCtheta in satellite cells of normal and regenerating muscle in the rat. (2009)
  • Author(s): Tokugawa S, Sakuma K, Fujiwara H, Hirata M, Oda R, Morisaki S, Yasuhara M, Kubo T
  • Journal Title: Neuropathology 29 Pages: 211-218
  • Peer Reviewed
• [Journal Article] The expression pattern of PKCtheta in satellite cells of normal and regenerating muscle in the rat (2009)
  • Author(s): Tokugawa S, Sakuma K, Fujiwara H, Hirata M, Oda R, Morisaki S, Yasuhara M, Kubo T
  • Journal Title: Neuropathology 29 Pages: 211-218
  • Peer Reviewed
• [Journal Article] The adaptive responses in several mediators linked with hypertrophy and atrophy of skeletal muscle after lower limb unloading in humans (2009)
  • Author(s): Sakuma K, Watanabe K, Hotta N, Koike T, Ishida K, Katayama K, Akima H
  • Journal Title: Acta Physiol (Oxf) 197 Pages: 151-159
  • Peer Reviewed
• [Journal Article] Age-related reductions in expression of serum response factor and myocardin- related transcription factor A in mouse skeletal muscles. (2008)
  • Author(s): Sakuma K, Akiho M, Nakashima H, Akima H, Yasuhara M
  • Journal Title: Biochim Biophys Acta Mol Basis Dis 1782 Pages: 453-461
  • Peer Reviewed
• [Journal Article] Cyclosporin A modulates cellular localization of MEF2C protein and blocks fiber hypertrophy in the overloaded soleus muscle of mice. (2008)
  • Author(s): Sakuma K, Akiho M, Nakashima H, Nakao R, Hirata M, Inashima S, Yamaguchi A, Yasuhara M
  • Journal Title: Acta Neuropath(Berl) 115 Pages: 663-674
  • Peer Reviewed
• [Journal Article] Expression of mRNA for specific fibroblast growth factors associates with that of the myogenic markers MyoD and PCNA in regenerating and overloaded rat plantaris muscle. (2008)
  • Author(s): Tanaka Y, Yamaguchi A, Fujikawa T, Sakuma K, Morita I, Ishii K
  • Journal Title: Acta Physiol(Oxf) 194 Pages: 149-159
  • Peer Reviewed
• [Journal Article] Age-related reductions in expression of serum response factor and myocardin-related transcription factor A in mouse skeletal muscles. (2008)
  • Author(s): Sakuma K, Akiho M, Nakashima H, Akima H, Yasuhara M
  • Journal Title: Biochim Biophys Acta Mol Basis Dis 1782 Pages: 453-461
  • Peer Reviewed
• [Journal Article] Cyclosporin A modulates cellular localization of MEF2C protein and blocks fiber hypertrophy in the overloaded soleus muscle of mice. (2008)
  • Author(s): Sakuma K, Akiho M, Nakashima H, Nakao R, Hirata M, Inashiraa S, Yamaguchi A, Yasuhara M
  • Journal Title: Acta Neuropath (Berl) 115 Pages: 663-674
  • Peer Reviewed
• [Journal Article] Expression of mRNA for specific fibroblast growth factors associates with that of the myogenic markers MyoD and PCNA in regenerating and overloaded rat plantaris muscle. (2008)
  • Author(s): Tanaka Y, Yamaguchi A, Fujikawa T, Sakuma K, Morita I, Ishii K
  • Journal Title: Acta Physiol (Oxf) 194 Pages: 149-159
  • Peer Reviewed
• [Presentation] 加齢性筋肉減弱症(サルコペニア)に対する自発性走運動の効果-神経栄養因子の変化に着目して- (2010)
  • Author(s): 佐久間邦弘、須藤みず紀、青井渉、山口明彦、狩野豊
  • Organizer: 第65回日本体力医学会
  • Place of Presentation: 千葉商科大学
  • Year and Date: 2010-09-16
• [Presentation] 発育期のラットの骨格筋成長に対するFGF-7の発現抑制の影響 (2010)
  • Author(s): 山口明彦、佐久間邦弘、森田勲
  • Organizer: 第65回日本体力医学会
  • Place of Presentation: 千葉商科大学
  • Year and Date: 2010-09-16
• [Presentation] 加齢性筋肉減弱症(サルコペニア)に対する自発性走運動の効果-神経栄養因子の変化に着目して- (2010)
  • Author(s): 佐久間邦弘, 山口明彦, 須藤みず紀, 青井渉, 狩野豊
  • Organizer: 第65回日本体力医学会
  • Place of Presentation: 千葉
• [Presentation] 発育期のラットの骨格筋成長に対するFGF-7の発現抑制の影響 (2010)
  • Author(s): 山口明彦, 佐久間邦弘, 森田勲
  • Organizer: 第65回日本体力医学会
  • Place of Presentation: 千葉
• [Presentation] ヒラメ筋肥大時における新生児型 (Neonatal) ミオシン陽性細胞の形態的特徴-カルシニューリン経路に着目して- (2009)
  • Author(s): 佐久間邦弘
  • Organizer: 第64回日本体力医学会大会
  • Place of Presentation: 新潟市 朱鷺メッセ
  • Year and Date: 2009-09-18
• [Presentation] ヒラメ筋肥大時における新生児型(Neonatal)ミオシン陽性細胞の形態的特徴-カルシニューリン経路に着目して- (2009)
  • Author(s): 佐久間邦弘, 山口明彦
  • Organizer: 第64回日本体力医学会
  • Place of Presentation: 新潟
• [Presentation] ヒラメ筋の代償性肥大における胎児型(Embryonic)ミオシンの発現様相-カルシニューリン経路に着目して- (2008)
  • Author(s): 佐久間 邦弘
  • Organizer: 第63回日本体力医学会大会
  • Place of Presentation: 別府市 別府ビーコンプラザ
  • Year and Date: 2008-09-19
• [Presentation] 筋肥大時のNotch-1およびFOXO1の発現様相 (2008)
  • Author(s): 佐久間 邦弘
  • Organizer: 第16回日本運動生理学会大会
  • Place of Presentation: 奈良市 帝塚山大学
  • Year and Date: 2008-08-03
• [Presentation] ヒラメ筋の代償性肥大における胎児型(Embryonic)ミオシンの発現様相-カルシニューリン経路に着目して- (2008)
  • Author(s): 佐久間邦弘
  • Organizer: 第63回日本体力医学会
  • Place of Presentation: 大分
• [Presentation] 筋肥大時のNotch-1およびFOXO1の発現様相 (2008)
  • Author(s): 佐久間邦弘
  • Organizer: 第16回日本運動生理学会
  • Place of Presentation: 奈良
• [Book] Cell Aging(Sarcopenia : molecular mechanisms and current therapeutic strategies.) (2011)
  • Author(s): Sakuma K, Yamaguchi A
  • Publisher: Nova Science Publishers, NY(in press)
• [Book] Recent Research Developments in LifeSciences(Serum response factor-dependent pathway : potential mediators of growth, regeneration, and hypertrophy of skeletal muscle.) (2011)
  • Author(s): Sakuma K, Yamaguchi A
  • Publisher: Research Signpost, India(in press)
• [Book] 運動生理学のニューエビデンス(筋萎縮)(編集宮村実晴) (2010)
  • Author(s): 佐久間邦弘
  • Publisher: 真興交易医書出版部
• [Book] 運動生理学のニューエビデンス (2010)
  • Author(s): 佐久間邦弘
  • Publisher: 真興交易医書出版部
• [Remarks] ホームページ等
  • URL: http://www.health.tut.ac.jp/sakuma/index.html