| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Research Abstract |
This study was investigated to clarify from the point view of an intracellular signaling pathway involving protein synthesis and proteolysis, and satellite cell whether or not the heat stress, antioxidant (astaxanthin ; Ax) administration, or their combinations can be an effective strategy for suppression of muscular atrophy and facilitation of restoration from muscular atrophy. The results obtained in this study suggested that heat stress and Ax administration attenuates muscle atrophy and accelerates the recovery from atrophy, due in part, to the promotion of protein synthesis and/or the suppression of protein degradation by HSP, and the activation of satellite cells.
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