| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Ghrelin, a peptide produced in the stomach, stimulates feeding and growth hormone secretion. I studied here whether ghrelin improved muscle atrophy, metabolic syndrome, and bedridden. Ghrelin treatment in mice exposed to hindlimb suspension-induced muscle atrophy increased insulin signal (anabolic function), and decreased expressions of atrophy-related E3 ubiquitin ligases (catabolic function). These anti-atrophic functions by ghrelin were indirectly effect in mice skeletal muscle. To exert ghrelin-induced anti-atrophic functions was necessary for increases of growth hormone secretion and food intake. Ghrelin treatment was effective for the prevention and improvement of muscle atrophy.
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