Effects of lengthening contractions on signaling molecules expressions in muscular protein synthesis and degradation
| Project/Area Number |
20500584
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Nippon Sport Science University |
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Principal Investigator |
NAKAZATO Koichi Nippon Sport Science University, 大学院・体育科学研究科, 教授 (00307993)
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| Co-Investigator(Kenkyū-buntansha) |
OCHI Eisuke 明治学院大学, 教養教育センター, 講師 (90468778)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | スポーツ生理学 / 伸張性収縮 / 角速度 / 神経損傷 / p75NTR / シュワン細胞 / タンパク質分解 / 筋肥大 / 筋損傷 |
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| Research Abstract |
We performed eccentric contractions (ECs) with fast (180 deg/sec : 180ECs) and slow (30 deg/sec : SLOWECs) velocities on rat gastrocnemius and examined effects on protein synthesis and degradation. Obtained results are shown below. (1) 30ECs induced protein synthesis. On the other hand, 180ECs induced protein degradation. (2) Especially in 180ECs, we found evidences for both AMPK activation and sciatic nerve injury. Eccentric contractions induce either protein synthesis or degradation depending on angular velocity.
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Report
(4 results)
Research Products
(14 results)
