Biochemical Mechanism of Coenzyme Q Redox Cycle for Showing Decreased Fatigue During Aerobic Exercise

• Project/Area Number: 20500587
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Kobe Gakuin University
• Principal Investigator: OKAMOTO Tadashi Kobe Gakuin University, 薬学部, 教授 (80194398)
• Co-Investigator(Kenkyū-buntansha): OKUNO Masaaki 神戸学院大学, 薬学部, 助教 (40359790)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: コエンザイムQ / ユビキノン / 有酸素運動 / 酸素ラジカル / 疲労 / コエンザイムQ10 / ユビキノール / 運動性疲労 / 酸化ストレス / 抗酸化作用 / エネルギー代謝

Research Abstract

The dynamics of CoQ10 antioxidant activities in vivo have not yet been fully elucidated, especially regarding the elimination of excessive oxygen radicals produced during intense aerobic exercise. The present study investigated the protective effects of CoQ10 against oxidative stress induced by aerobic swimming exercise.
Protective effects of CoQ10 were observed in 4-week CoQ10 administration such as decreasing in serum lactate level and serum LDH activities, elongation swimming duration. Moreover, NADPH-CoQ reductase activity also increased in CoQ10 administration group. These results suggest that the reduced form of CoQ10 with NADPH-CoQ reductase constituted a fundamental defense system against oxidative stress and fatigue induced by aerobic exercise.

Research Products

• [Journal Article] NADPH-dependent coenzyme Q reductase is the main enzyme responsible to the reduction of non-mitochondrial CoQ in cells (2008)
  • Author(s): Takayuki Takahashi, et al.
  • Journal Title: Biofactors 32 Pages: 59-70
  • Peer Reviewed
• [Presentation] ランチョンセミナー;コエンザイムQ10研究の薬学的アプローチと最近の話題 (2009)
  • Author(s): 岡本正志
  • Organizer: 第54回日本聴覚医学会総会・学術講演会
  • Place of Presentation: 新横浜プリンスホテル(横浜)
  • Year and Date: 2009-10-23
• [Presentation] コエンザイムQ10研究の薬学的アプローチと最近の話題 (2009)
  • Author(s): 岡本正志
  • Organizer: 第54回日本聴覚医学会総会(ランチョンセミナー)
  • Place of Presentation: 新横浜プリンスホテル(神奈川)
  • Year and Date: 2009-10-23
• [Presentation] 還元型コエンザイムQ10 研究の新しい展開 (2009)
  • Author(s): 岡本正志
  • Organizer: 第8回生体キノン研究会
  • Place of Presentation: 中央大学駿河台記念館(東京)(招待講演)
  • Year and Date: 2009-09-18