The effects of exercise-induced stress on the brains of spontaneously hypertensive rats
| Project/Area Number |
20500588
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
MIYAMOTO Osamu Kawasaki Medical School, 医学部, 教授 (00253287)
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| Co-Investigator(Kenkyū-buntansha) |
SUMITANI Kazunori 香川大学, 医学部, 教務職員 (40294772)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ダークニューロン / 海馬 / 高血圧発症モデルラット / 運動ストレス / 酸化障害 / エイコサペンタエン酸 / 高血圧自然発症ラット / 神経細胞 / 活性酸素 / 運動 / ストレス / 酸化ストレス |
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| Research Abstract |
The effects of hard exercise on the brains were investigated using spontaneously hypertensive rats (SHR). The dark neurons appeared in the hippocampus in SHR after 3-wk exercise, but not in normotensive rats. Protein carbonylation were observed in the SHR brains and the appearance of dark neurons was inhibited by administration of eicosapentaenoic acid. These results suggest that the exercise-induced oxidative stress damages brain and SHR is vulnerable to oxidative stress.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Anti-oxidative effects of D-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat2011
Author(s)
Nakamura T, Tanaka S, Hirooka K, Toyoshima T, Kawai N, Tamiya T, Shiraga F, Tokuda M, Keep R, Itano T, Miyamoto O
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Journal Title
Neurosci lett Vol.487
Pages: 103-106
Related Report
Peer Reviewed
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[Journal Article] 3CB2, a marker of radial glia, expression after experimental intracerebral hemorrhage : role of thrombin2008
Author(s)
Nakamura T, Miyamoto O, Toyoshima T, Hirooka K, Kawai N, Shiraga F, Tamiya T, Xi G, Keep R, Itano T
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Journal Title
Brain Res Vol.1226
Pages: 156-162
Related Report
Peer Reviewed
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