The effects of exercise-induced stress on the brains of spontaneously hypertensive rats

• Project/Area Number: 20500588
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Kawasaki Medical School
• Principal Investigator: MIYAMOTO Osamu Kawasaki Medical School, 医学部, 教授 (00253287)
• Co-Investigator(Kenkyū-buntansha): SUMITANI Kazunori 香川大学, 医学部, 教務職員 (40294772)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: ダークニューロン / 海馬 / 高血圧発症モデルラット / 運動ストレス / 酸化障害 / エイコサペンタエン酸 / 高血圧自然発症ラット / 神経細胞 / 活性酸素 / 運動 / ストレス / 酸化ストレス

Research Abstract

The effects of hard exercise on the brains were investigated using spontaneously hypertensive rats (SHR). The dark neurons appeared in the hippocampus in SHR after 3-wk exercise, but not in normotensive rats. Protein carbonylation were observed in the SHR brains and the appearance of dark neurons was inhibited by administration of eicosapentaenoic acid. These results suggest that the exercise-induced oxidative stress damages brain and SHR is vulnerable to oxidative stress.

Research Products

• [Journal Article] Anti-oxidative effects of D-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat (2011)
  • Author(s): Nakamura T, Tanaka S, Hirooka K, Toyoshima T, Kawai N, Tamiya T, Shiraga F, Tokuda M, Keep R, Itano T, Miyamoto O
  • Journal Title: Neurosci lett Vol.487 Pages: 103-106
  • Peer Reviewed
• [Journal Article] Anti-oxidative effects of D-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat (2011)
  • Author(s): Nakamura Takehiro
  • Journal Title: Neurosci Letter Volume: 487巻 Pages: 103-106
  • Peer Reviewed
• [Journal Article] Stage- and region-specific cyclooxygenase expression and effects of a selective COX-1 inhibitor in the mouse amygdala kindling model (2009)
  • Author(s): Tanaka S, Nakamura T, Sumitani K, Takahashi F, Konishi R, Itano T, Miyamoto O
  • Journal Title: Neurosci Res Vol.65 Pages: 79-87
  • NAID: 10027500467
  • Peer Reviewed
• [Journal Article] 運動による脳虚血耐性獲得とその機序の解明 (2009)
  • Author(s): 宮本修
  • Journal Title: 両備てい園記念財団試験研究論叢 Vol.24 Pages: 115-121
• [Journal Article] Stage- and region-specific cyclooxygenase expression and effects of a selective COX-1 inhibitor in the mouse amygdala kindling model (2009)
  • Author(s): Tanaka Shinji
  • Journal Title: Neurosci Res 65巻 Pages: 79-87
  • Peer Reviewed
• [Journal Article] 運動による脳虚血耐性獲得とその機序の解明 (2009)
  • Author(s): 宮本修
  • Journal Title: 生物学に関する試験研究論叢 24巻 Pages: 115-121
• [Journal Article] 3CB2, a marker of radial glia, expression after experimental intracerebral hemorrhage : role of thrombin (2008)
  • Author(s): Nakamura T, Miyamoto O, Toyoshima T, Hirooka K, Kawai N, Shiraga F, Tamiya T, Xi G, Keep R, Itano T
  • Journal Title: Brain Res Vol.1226 Pages: 156-162
  • Peer Reviewed
• [Journal Article] Both amacrine and bipolar cells release glutamate in the ratretina after ischemia/reperfusion insult in vitro (2008)
  • Author(s): Du Ying
  • Journal Title: Curr Eye Res 33 Pages: 782-788
  • Peer Reviewed
• [Journal Article] 3CB2, a marker of radial glia, expression after experimental intracerebral hemorrhage : role of thrombin (2008)
  • Author(s): Nakamura Takehiro
  • Journal Title: Brain Res 1226 Pages: 156-162
  • Peer Reviewed
• [Journal Article] Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage (2008)
  • Author(s): Nakamura Takehiro
  • Journal Title: Stroke 39 Pages: 463-469
  • Peer Reviewed
• [Presentation] 脳梗塞後の短期間運動が認知機能の回復に及ぼす効果 (2010)
  • Author(s): 氷見直之,高橋尚,古我知成,丸山恵美,国安勝司,宮本修
  • Organizer: 第65回日本体力医学会
  • Place of Presentation: 市川市
  • Year and Date: 2010-09-16
• [Presentation] 脳梗塞後の短期間運動が認知機能の回復に及ぼす効果 (2010)
  • Author(s): 氷見直之
  • Organizer: 第65回日本体力医学会
  • Place of Presentation: 千葉商科大学(市川市)
  • Year and Date: 2010-09-16
• [Presentation] キンドリングマウスにおけるNG2細胞の形態的変化について (2010)
  • Author(s): 板野俊文,中川利孝,田中眞司,中村丈洋,豊島哲彦,宮本修
  • Organizer: 第87回日本生理学会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-05-20
• [Presentation] マイクロスフェア注入による脳梗塞ラットに対する運動の初期効果 (2010)
  • Author(s): 氷見直之、高橋尚、中村恵美、国安勝司、成田和彦、古我知成、宮本修
  • Organizer: 第87回日本生理学会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-05-19
• [Presentation] マイクロスフェア注入による脳梗塞がトレッドミル走行時の乳酸性閾値に及ぼす影響 (2010)
  • Author(s): 高橋尚、氷見直之、国安勝司、宮本修、古我知成
  • Organizer: 第87回日本生理学会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-05-19
• [Presentation] Stage- and region-specific cyclooxygenase expression and effects of a selective COX-1 inhibitor in the mouse amygdala kindling model (2009)
  • Author(s): Miyamoto O, Tanaka S, Nakamura T, Konishi R, Itano T
  • Organizer: International Congress of Physiological Sciences
  • Place of Presentation: kyoto
  • Year and Date: 2009-08-01
• [Presentation] Delayed protease inhibitor treatment reduces brain damage after intracerebral hemorrhage in rat (2009)
  • Author(s): Nakamura T, Okabe N, Lu F, Kuroda Y, Tamiya T, Miyamoto O, Itano T
  • Organizer: International Congress of Physiological Sciences
  • Place of Presentation: Kyoto
  • Year and Date: 2009-08-01
• [Presentation] Delayed serine protease inhibitor treatment reduces brain damage after intracerebral hemorrhage in rat (2009)
  • Author(s): Nakamura Takehiro
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2009-08-01
• [Presentation] ラット脳出血モデルにおける運動によるプレコンディショニングの効果 (2008)
  • Author(s): 住谷和則、中村丈洋、山神眞一、宮本賢作、宮本修
  • Organizer: 第63回日本体力医学会
  • Place of Presentation: 別府市
  • Year and Date: 2008-09-18
• [Presentation] ラット脳出血モデルにおける運動によるプレコンディショニングの効果 (2008)
  • Author(s): 住谷和則
  • Organizer: 第63回日本体力医学会大会
  • Place of Presentation: 大分県別府市
  • Year and Date: 2008-09-18