The relation between effect of passive smoking on immune system in the lung and lung carcinogenesis
Project/Area Number |
20500606
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied health science
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Research Institution | Kyoto Sangyo University |
Principal Investigator |
TAKEUCHI Minoru Kyoto Sangyo University, 総合生命科学部, 教授 (70257773)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | 受動喫煙 / 副流煙 / 肺胞マクロファージ / 免疫機能 / DNA損傷 / 副流煙水溶性抽出物 / 肺癌 / 発癌 / 肺癌発生 / 8-OHdG |
Research Abstract |
Side-stream tobacco smoke(STS) increased the number and ROS productions of AM. Phagocytic activity, expressions of TNF-αmRNA and TLRs were inhibited by STS. STS induced DNA damage in AM. STS was a risk factor for DNA damage of AM and inhibited the immunological functions in AM mediated by DNA damage. The inhibition of immunological functions in AM by STS may be associated with carcinogenesis in the lung.
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Report
(4 results)
Research Products
(72 results)
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[Journal Article] Interleukin-28B acts synergistically with cisplatin to suppress the growth of head and neck squamous cell carcinoma.2011
Author(s)
Koichiro Yoshimoto, Tsunao Kishida, Hiroshi Nakano, Masahiro Matsui, Masaharu Shin-Ya, Taketoshi Shimada, Shigeru Nakai, Jiro Imanishi, Minoru Takeuchi, Yasuo Hisa, Osam Mazda.
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Journal Title
Journal of Immunotherapy. 34(2)
Pages: 139-48
Related Report
Peer Reviewed
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[Journal Article] Environmental mutagens may be implicated in emergence of drug-resistant microorganisms.
Author(s)
Miyahara, Emiko, Nishie, Makiko, Takumi, Shota, Miyanohara, Hiroaki, Nishi, Junichiro, Yoshiie, Kiyotaka, Oda, Hiroshi, Takeuchi, Minoru, Komatsu, Masaharu, Aoyama, Kohji, Horiuchi, Masahisa, Takeuchi, Toru.
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Journal Title
FEMS Microbiology Letters In press
Related Report
Peer Reviewed
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[Presentation] Cigarette Smoke Induces DNA Damage but not Apoptosis in Alveolar Macrophages.2010
Author(s)
Yuriko Hirono, Shinichi Inoue, Mayuko Miyagawa, Takahiro Ishida, Masaaki Sakura, Sumire Inaga, Osamu Mazda, Sonoko Nagai, Toru Takeuchi, K.E.Pinkerton, Minoru Takeuchi
Organizer
ATS 2010 International Conference
Place of Presentation
New Orleans, Louisiana
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[Presentation] Repair of DNA Damage in Alveolar Macrophages Induced by Cigarette Smoke Exposure.2009
Author(s)
Yuriko Hirono, Shinichi Inoue, Mayuko Miyagawa, Takahiro Ishida, Sumire Inaga, Tomonori Naguro, Osamu Mazda, Sonoko Nagai, Toru Takeuchi, K.E.Pinkerton, Minoru Takeuchi
Organizer
第68回日本癌学会学術総会
Place of Presentation
横浜
Related Report
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[Presentation] Inhibition of immunological functions in alveolar macrophages (AM) related with DNA damage by cigarette tobacco smoke exposure.2009
Author(s)
M Takeuchi, Y Hirono, M Miyagawa, S Inoue, T Ishida, S Inaga, T Naguro, T Takeuchi, S Nagai, K E pinkerton
Organizer
ATS 2009 International Conference
Place of Presentation
San Diego, California
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