Prediction of metabolic syndrome for the prevention of life style diseases

• Project/Area Number: 20500616
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Osaka University
• Principal Investigator: TAKIHARA Keiko Osaka University, 保健センター, 教授 (70252640)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 生活習慣病 / 過酸化脂質 / 肥満 / 内臓脂肪 / 動脈硬化 / サイトカイン

Research Abstract

Among classical metabolic syndrome risk factors, the abdominal obesity plays pivotal role for the progression of atherosclerosis. In addition to adipocytokine, oxidative stress is an important pathogenic factor for the onset of metabolic syndrome.

Research Products

• [Journal Article] Pulmonary arterial hypertension associated with chronic active Epstein-Barr virus infection. (2011)
  • Author(s): T.Hashimoto, Y.Sakata, K.Yamauchi-Takihara, I.Komuro
  • Journal Title: Internal Medicine 50 Pages: 119-124
• [Journal Article] What we learned from pandemic H1N1influenza A. (2011)
  • Author(s): 瀧原圭子
  • Journal Title: Cardiovasc Res 89 Pages: 483-484
• [Journal Article] Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-Met signaling. (2011)
  • Author(s): W.Shioyama, Y.Nakaoka, K.Yamauchi-Takihara, T.Kodama, T.Hirano, N.Mochizuki, I.Komuro
  • Journal Title: Circ Res 108 Pages: 664-675
• [Journal Article] 肺高血圧症:どのように検査し診断するか (2011)
  • Author(s): 溝手勇、瀧原圭子
  • Journal Title: Heart View 15 Pages: 14-19
• [Journal Article] Pulmonary arterial hypertension associated with chronic active Epstein-Barr virus infection. (2011)
  • Author(s): T.Hashimoto, Y.Sakata, T.Maeda, Y.Arita, W.Shioyama, Y.Nakaoka, K.Aozasa, Y.Kanakura, K.Yamauchi-Takihara, I.Komuro.
  • Journal Title: Internal Medicine Volume: 50 Pages: 119-124
  • Peer Reviewed
• [Journal Article] What we learned from pandemic H1N1 influenza A. (2011)
  • Author(s): K.Yamauchi-Takihara
  • Journal Title: Cardiovasc Res Volume: 89 Pages: 483-484
  • Peer Reviewed
• [Journal Article] The efficacy of Tocilizumab in a patient with pulmonary arterial hypertension associated with Castleman's disease. (2010)
  • Author(s): Y.Arita, Y.Sakata, Y.Kanakura, K.Yamauchi-Takihara
  • Journal Title: Heart Vessels 25 Pages: 444-447
• [Journal Article] Pulmonary arterial hypertension associated with bone marrow transplantation. (2010)
  • Author(s): H.Nakaoka, Y.Sakata, K.Yamauchi-Takihara
  • Journal Title: J Cardiol Cases 2
• [Journal Article] SHP2 negatively regulates skeletal a-actin gene expression downstream of Gp130 signaling in cardiomyocytes. (2010)
  • Author(s): Y.Nakaoka, W.Shioyama, K.Yamauchi-Takihara, T.Hirano, I.Komuro, N.Mochizuki
  • Journal Title: J Mol Cell Cardiol 49 Pages: 157-164
• [Journal Article] 特集:循環器疾患と他臓器疾患肺高血圧症に対する新しい薬物療法 (2010)
  • Author(s): 瀧原圭子
  • Journal Title: 循環器内科 67 Pages: 351-358
• [Journal Article] 特集:肺動脈性肺高血圧症エンドセリン受容体拮抗薬 (2010)
  • Author(s): 瀧原圭子
  • Journal Title: 循環器内科 67 Pages: 494-499
• [Journal Article] 混合性結合組織病に合併した肺動脈性肺高血圧症に対するボセンタンの著効例 (2010)
  • Author(s): 瀧原圭子
  • Journal Title: モダンフィジシャン臨時増刊号 30 Pages: 80-83
• [Journal Article] 特集:心筋症・心筋 (2010)
  • Author(s): 神谷千津子、瀧原圭子
  • Journal Title: 炎産褥期心筋症総合臨床 59 Pages: 1809-1814
• [Journal Article] 特集:心血管疾患における性差医療序文 (2010)
  • Author(s): 瀧原圭子
  • Journal Title: 循環器内科 68 Pages: 97-98
• [Journal Article] The efficacy of Tocilizumab in a patient with pulmonary arterial hypertension associated with Castleman's disease (2010)
  • Author(s): Y.Arita, Y.Sakata, T.Sudo, T.Maeda, K.Matsuoka, K.Tamai, K Higuchi, W.Shioyama, Y.Nakaoka, Y.Kanakura, K.Yamauchi-Takihara.
  • Journal Title: Heart Vessels Volume: 25 Pages: 444-447
  • Peer Reviewed
• [Journal Article] Pulmonary arterial hypertension associated with bone marrow transplantation. (2010)
  • Author(s): H.Nakaoka, Y.Sakata, M.Yamamoto, Y.Arita, W.Shioyama, Y.Nakaoka, S.Yamashita, I.Komuro, K.Yamauchi-Takihara.
  • Journal Title: J Cardiol Cases Volume: 2
  • Peer Reviewed
• [Journal Article] SHP2 negatively regulates skeletal a-actin gene expression downstream of Gp130 signaling in cardiomyocytes. (2010)
  • Author(s): Y.Nakaoka, W.Shioyama, K.Higuchi, Y.Arita, T.Kuroda, Y.Fujio, K.Yamauchi-Takihara, T.Hirano, I.Komuro, N.Mochizuki.
  • Journal Title: J Mol Cell Cardiol Volume: 49 Pages: 157-164
  • Peer Reviewed
• [Journal Article] 循環器疾患と他臓器疾患:肺高血圧症に対する新しい薬物療法 (2010)
  • Author(s): 瀧原圭子
  • Journal Title: 循環器内科 Volume: 67 Pages: 351-358
• [Journal Article] 肺動脈性肺高血圧症:エンドセリン受容体拮抗薬 (2010)
  • Author(s): 瀧原圭子
  • Journal Title: 循環器内科 Volume: 67 Pages: 494-499
• [Journal Article] 心筋症・心筋炎基礎と臨床の最前線2010:産褥期心筋症 (2010)
  • Author(s): 神谷千津子, 瀧原圭子
  • Journal Title: 総合臨床 Volume: 59 Pages: 1809-1814
• [Journal Article] 心血管疾患における性差医療:序文 (2010)
  • Author(s): 瀧原圭子
  • Journal Title: 循環器内科 Volume: 68 Pages: 97-98
• [Journal Article] The efficacy of Tocilizumab in a patient with pulmonary arterial hypertension associated with Castleman's disease (2010)
  • Author(s): Y.Arita, Y.Sakata, T.Sudo, T.Maeda, K.Matsuoka, K.Tamai, K.Higuchi, W.Shioyama, Y.Nakaoka, Y.Kanakura, K.Yamauchi-Takihara
  • Journal Title: Heart Vessels (in press)
  • Peer Reviewed
• [Journal Article] Pulmonary arterial hypertension associated with bone marrow trans plantation (2010)
  • Author(s): H.Nakaoka, Y.Sakata, M.Yamamoto, T.Maeda, Y.Arita, W.Shioyama, Y.Nakaoka, Y.Kanakura, S.Yamashita, I.Komuro, K.Yamauchi-Takihara
  • Journal Title: J Cardiol Cases (in press)
  • Peer Reviewed
• [Journal Article] Clinical significance of plasma endothelin-1 level after bosentan administration in pulmonary arterial hypertension. (2009)
  • Author(s): Y.Hiramoto, Y.Fujio, K.Yamauchi-Takihara
  • Journal Title: J Cardiol 53 Pages: 374-380
• [Journal Article] 特集:心不全2009心不全病態におけるサイトカインの関与 (2009)
  • Author(s): 瀧原圭子
  • Journal Title: 総合臨床 58 Pages: 574-579
• [Journal Article] メタボリックシンドローム・リスクファクターのなかで最も重要なものは腹部肥満である (2009)
  • Author(s): 瀧原圭子、西田誠、守山敏樹、杉田義郎
  • Journal Title: メタボリックシンドローム 5 Pages: 123-128
• [Journal Article] 混合性結合組織病(MCTD)に合併した肺高血圧症に対するベラプロストナトリウム徐放錠の著効例 (2009)
  • Author(s): 瀧原圭子
  • Journal Title: リウマチ科 42 Pages: 236-240
• [Journal Article] 特集:肺高血圧症-基礎と臨床の最前線 肺高血圧病態におけるサイトカインの関与 (2009)
  • Author(s): 瀧原圭子
  • Journal Title: 総合臨床 58 Pages: 2242-2245
• [Journal Article] 循環器疾患で重要な神経体液性因子-基礎から臨床へ-サイトカイン (2009)
  • Author(s): 瀧原圭子
  • Journal Title: Heart View 13 Pages: 105-112
• [Journal Article] Clinical significance of plasma endothelin-1 level after bosentan administration in pulmonary arterial hypertension (2009)
  • Author(s): Y.Hiramoto, W.Shioyama, K.Higuchi, Y.Arita, T.Kuroda, Y.Sakata, Y.Nakaoka, Y.Fujio, K.Yamauchi-Takihara
  • Journal Title: J Cardiology 53 Pages: 374-380
  • Peer Reviewed
• [Journal Article] メタボリックシンドローム・リスクファクターのなかで最も重要なものは腹部肥満である-炎症マーカーとIMTによる検討- (2009)
  • Author(s): 瀧原圭子, 西田誠, 守山敏樹, 杉田義郎
  • Journal Title: メタボリックシンドローム 5 Pages: 123-128
• [Journal Article] 特集 : 肺高血圧症-基礎と臨床の最前線 肺高血圧病態におけるサイトカインの関与 (2009)
  • Author(s): 瀧原圭子
  • Journal Title: 総合臨床 58 Pages: 2242-2245
• [Journal Article] (2009)
  • Author(s): 瀧原圭子
  • Journal Title: 重症心不全の予防と治療 北風政史 編(中外医学社) Pages: 21-26
• [Journal Article] Granulocyte colony-stimulating factor prevents reperfusion injury after heart preservation. (2008)
  • Author(s): T.Higuchi, K.Yamauchi-Takihara, Y.Sawa
  • Journal Title: Ann Thorac Surg 85 Pages: 1367-1373
• [Journal Article] gp130 signaling and heart failure (Review). (2008)
  • Author(s): 瀧原圭子
  • Journal Title: Future Cardiology 4 Pages: 427-437
• [Journal Article] サイトカインシグナルによる心不全の制御機構 (2008)
  • Author(s): 瀧原圭子、中岡良和
  • Journal Title: 心臓 40 Pages: 181-186
• [Journal Article] 特集:心筋症の最前線6-d (2008)
  • Author(s): 瀧原圭子
  • Journal Title: サイトカインHeart View 12 Pages: 982-987
• [Journal Article] 特集:禁煙を科学する (2008)
  • Author(s): 瀧原圭子
  • Journal Title: 循環器疾患総合臨床 57 Pages: 2136-2140
• [Journal Article] Granulocyte colony-stimulating factor prevents reperfusion injury after heart preservation (2008)
  • Author(s): T.Higuchi, K.Yamauchi-Takihara, G.Matsumiya, N.Fukushima, H.Ichikawa, T.Kuratani, Y.Maehata, Y.Sawa
  • Journal Title: Ann Thorac Surg 85 Pages: 1367-1373
  • Peer Reviewed
• [Journal Article] gp130 signaling and heart failure (2008)
  • Author(s): K.Yamauchi-Takihara
  • Journal Title: Future Cardiology 4 Pages: 427-437
  • Peer Reviewed
• [Journal Article] Interaction of scaffolding adaptor protein Gab1 with tyrosine phosphatase SHP2 negatively regulate IGF-1-dependentmyogenic differentiation via the ERK1/2 signaling pathway (2008)
  • Author(s): T.Koyama, Y.Nakaoka Y.Fujio, K.Nishida, S.Sugiyama, K.Okamoto, K.Yamauchi-Takihara, M.Yoshimura, S.Mochizuki, M.Hori, T.Hirano, N.Mochizuki
  • Journal Title: J Biol Chem 283 Pages: 24234-24244
  • Peer Reviewed
• [Journal Article] 禁煙を科学する ―循環器疾患― (2008)
  • Author(s): 瀧原圭子
  • Journal Title: 綜合塩床 57 Pages: 2136-2140
• [Journal Article] 特集:心筋症の最前線6-dサイトカイン (2008)
  • Author(s): 瀧原圭子
  • Journal Title: Heart View 12 Pages: 982-987
• [Journal Article] (2008)
  • Author(s): 瀧原圭子
  • Journal Title: 別冊 日本臨床 呼吸器症候群(第2版)V肺循環の異常 肺静脈閉塞性疾患(日本臨床社) Pages: 364-367
• [Presentation] Treatment of Pulmonary Hypertension as an Inflammatory Disease-possibility for specific inhibition of inflammatory cytokine. (2011)
  • Author(s): 瀧原圭子
  • Organizer: 第75回日本循環器学会学術集会シンポジウム
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2011-03-19
• [Presentation] Progression of subclinical atherosclerosis associates not with change of risk factors but with change of adiposity-Two Years Follow-up Study- (2011)
  • Author(s): 西田誠, 外山裕美子, 彦惣俊吾, 杉田義郎, 守山敏樹, 山下静也, 瀧原圭子
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2011-03-18
• [Presentation] Serum apolipoprotein B-48 Level, not remnant like particle cholesterol level associates with subclinical atherosclerosis in non-obese men. (2011)
  • Author(s): 西田誠, 外山裕美子, 彦惣俊吾, 増田大作, 杉田義郎, 守山敏樹, 山下静也, 小室一成, 瀧原圭子
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2011-03-18
• [Presentation] Clinical implication of IL-6 concentration in patients with pulmonary hypertension. (2011)
  • Author(s): 有田陽, 中岡良和, 橋本崇弘, 樋口香織, 塩山渉, 藤尾慈, 瀧原圭子, 小室一成
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2011-03-17
• [Presentation] Progression of Subclinical Atherosclerosis Associates not with Change of Risk Factors but with Change of Adiposity-Two Years Follow-up Study- (2011)
  • Author(s): M.Nishida, K.Yamauchi-Takihara
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Serum Apolipoprotein B-48 Level, not Remnant Like Particle Cholesterol Level Associates with Subclinical Atherosclerosis in Non-obese Men. (2011)
  • Author(s): M.Nishida, I.Komuro, K.Yamauchi-Takihara
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Clinical implication of IL-6 concentration in patients with pulmonary hypertension. (2011)
  • Author(s): Y. Arita, K. Yamauchi-Takihara, I. Komuro
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Gab1 Negatively Regulates Angiotensin II-accelerated Atherosclerosis in Apolipoprotein E Deficient Mice. (2011)
  • Author(s): K. Higuchi, K. Yamauchi-Takihara, R. Morishita, N. Mochizuki, T. Hirano, I. Komuro
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Gab1 is Critically Involved in HGF-dependent Postnatal Angiogenesis after Ischemia. (2011)
  • Author(s): W. Shioyama, K. Yamauchi-Takihara, T. Hirano, N. Mochizuki, I. Komuro
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Treatment of Pulmonary Hypertension as an Inflammatory Disease -possibility for specific inhibition of inflammatory cytokine. (2011)
  • Author(s): K. Yamauchi-Takihara
  • Organizer: 第75回日本循環器学会学術集会シンポジウム
  • Place of Presentation: 横浜
• [Presentation] Smoking promotes subclinical atherosclerosis in apparently healthy men (2010)
  • Author(s): 瀧原圭子, 西田誠, 外山裕美子, 彦惣俊吾, 杉田義郎
  • Organizer: 第74回日本循環器学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-07
• [Presentation] SHP2 plays an essential role for gp130-dependent cardiomyocyte hypertrophy through negative regulation of skeletal alpha-actin gene. (2010)
  • Author(s): Y. Nakaoka, K. Yamauchi-Takihara, N. Mochizuki, I. Komuro
  • Organizer: American Heart Association Scientific Sessions 2010
  • Place of Presentation: Chicago
• [Presentation] Smoking promotes subclinical atherosclerosis in apparently healthy men. (2010)
  • Author(s): K.Yamauchi-Takihara, M.Nishida, Y.Toyama, S.Hikoso, Y.Sugita
  • Organizer: 第74回日本循環器学会学術集会
  • Place of Presentation: 京都
• [Presentation] Interaction of docking protein Gab1 with SHP2 is essential for the HGF-dependent endothelial maintenance through activation of ERK5-KLF2 pathway. (2010)
  • Author(s): W. Shioyama, K. Yamauchi-Takihara, T. Hirano, T. Kodama, N. Mochizuki, I. Komuro
  • Organizer: 第74回日本循環器学会学術集会
  • Place of Presentation: 京都
• [Presentation] 循環器診療における女性を再考する (2009)
  • Author(s): 瀧原圭子
  • Organizer: 第23回日本冠疾患学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-18
• [Presentation] Progression of Subclinical Atherosclerosis Associates with Visceral Fat Accumulation and Lifestyle (2009)
  • Author(s): 西田誠、外山裕美子、彦惣俊吾、杉田義郎、守山敏樹、瀧原圭子
  • Organizer: 第73回日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Presentation] 循環器診療における女性を再考する (2009)
  • Author(s): 瀧原圭子、西田誠、守山敏樹、杉田義郎
  • Organizer: 第23回日本冠疾患学会学術集会コーヒーブレークセミナー
  • Place of Presentation: 大阪
• [Presentation] 初期動脈硬化病変に対するメタボリックシンドローム等のリスクに関する男女差の検討 (2009)
  • Author(s): 西田誠、外山裕美子、彦惣俊吾、守山敏樹、杉田義郎、山下静也、瀧原圭子
  • Organizer: 第23回日本冠疾患学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Interaction of docking protein Gab1with tyrosine phosphatase SHP2 regulates HGF-dependent ERK5 activation and upregulation of KLF2 in the vascular endothelium. (2009)
  • Author(s): W. Shioyama, Y. Nakaoka, Y. Fujio, K. Yamauchi-Takihara, N. Mochizuki, I. Komuro
  • Organizer: American Heart Association Scientific Sessions 2009
  • Place of Presentation: Orlando
• [Presentation] Progression of subclinical atherosclerosis associates not with change of risk factors but with change of adiposity -Two years follow-up study- (2009)
  • Author(s): M.Nishida, S.Yamashita, K.Yamauchi-Takihara
  • Organizer: 第41回日本動脈硬化学会学術集会
  • Place of Presentation: 山口
• [Presentation] 骨髄移植後に肺高血圧症を呈した急性骨髄性白血病の一例 (2009)
  • Author(s): 中岡創・坂田泰史・瀧原圭子
  • Organizer: 第10回肺高血圧症治療研究会
  • Place of Presentation: 東京
• [Presentation] Progression of subclinical atherosclerosis associates with visceral fat accumulation and lifestyle. (2009)
  • Author(s): M.Nishida, K.Yamauchi-Takihara
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Clinical significance of plasma endothelin-1 level after bosentan administration in pulmonary arterial hypertension. (2009)
  • Author(s): Y. Hiramoto, Y. Fujio, K. Yamauchi-Takihara
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Scaffolding docking proteins Gab1 is essential for HGF-mediated endothelial signaling and angiogenesis after hind-limb ischemia. (2009)
  • Author(s): W. Shioyama, K. Yamauchi-Takihara, Y. Nakaoka
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
• [Presentation] メタボリックシンドローム・リスクファクターのなかで最も重要なものは腹部肥満である―炎症マーカーとIMTによる検討― (2008)
  • Author(s): 瀧原圭子、西田誠、守山敏樹、杉田義郎
  • Organizer: 第4回高尿酸血漿・メタボリックシンドロームリサーチフォーラム
  • Place of Presentation: 大阪
  • Year and Date: 2008-07-26
• [Presentation] SHP2 negatively regulate skeletal alpha-actin gene expression downstream of LIF-dependent hypertrophic signaling in cardiomyocytes. (2008)
  • Author(s): W. Shioyama, K. Yamauchi-Takihara, N. Mochizuki
  • Organizer: 第25回国際心臓研究学会日本部会
  • Place of Presentation: 横浜
• [Presentation] Scaffolding docking proteins Gab1 is essential for HGF-mediated endothelial signaling and angiogenesis after hind-limb ischemia. (2008)
  • Author(s): W. Shioyama,, K. Yamauchi-Takihara, N. Mochizuki, M Hori
  • Organizer: American Heart Association Scientific Sessions 2008
  • Place of Presentation: New Orleans
• [Presentation] Effectiveness of Bosentan in Pulmonary Arterial Hypertension. (2008)
  • Author(s): Yamauchi-Takihara K.
  • Organizer: 5th Scientific Symposium. Strategic Perception for PAH Management
  • Place of Presentation: Tokyo
• [Presentation] メタボリックシンドローム・リスクファクターのなかで最も重要なものは腹部肥満である-炎症マーカーとIMT による検討- (2008)
  • Author(s): 瀧原圭子、西田誠、守山敏樹、杉田義郎
  • Organizer: 第4回高尿酸血漿・メタボリックシンドロームリサーチフォーラム
  • Place of Presentation: 大阪
• [Book] 右心不全・肺性心今日の治療指針2011年版 (2011)
  • Author(s): 瀧原圭子
  • Publisher: 医学書院
• [Book] Emerging concepts and new therapeutic targets in pulmonary arterial hypertension(「AHAハイライト2010」)(篠山重威編) (2011)
  • Author(s): 瀧原圭子
  • Publisher: 協和企画 印刷中
• [Book] 新規開発中の内服薬 肺高血圧症診療マニュアル(伊藤浩、松原広己編) (2011)
  • Author(s): 瀧原圭子
  • Publisher: 南江堂 印刷中
• [Book] 今日の治療指針2011年版右心不全・肺性心 (2011)
  • Author(s): 瀧原圭子
  • Total Pages: 1
  • Publisher: 医学書院
• [Book] 形態学から(重症心不全の予防と治療)(北風政史編) (2009)
  • Author(s): 瀧原圭子
  • Publisher: 中外医学社
• [Remarks] ホームページ等