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Studies of food components having anti-oxidant effects on the 'depository gene' expression and its clinical application.

Research Project

Project/Area Number 20500619
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionKyushu University

Principal Investigator

IKUYAMA Shoichiro  Kyushu University, 生体防御医学研究所, 准教授 (20184393)

Co-Investigator(Kenkyū-buntansha) OBA Koichi  九州大学, 病院, 助教 (50444857)
権藤 重喜  九州大学, 大学病院, 助教 (80444842)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords生活習慣病 / 補完代替医療 / 健康食品 / 抗酸化 / 細胞内脂肪滴 / 遺伝子転写調節 / 遺伝子 / 脂質 / マイクロアレイ / 発現制御
Research Abstract

Excessive intracellular lipid accumulation causes various diseases such as atherosclerosis, fatty liver, etc. Specific proteins as we named 'depository genes' are involved in this process. We tested effects of an extract of French maritime pine, a widely used dietary supplement, on the expression of these genes in macrophages and liver cells. The compound suppressed the gene expression and lipid accumulation in both cells by different molecular mechanisms. We also analyzed the change in mRNA expression in white blood cells before and after ingestion of this compound using DNA microarray analysis. We identified 12 increased and 64 decreased genes, although physiological significance remains to be clarified at this moment.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (33 results)

All 2010 2009 2008 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (16 results) Remarks (1 results)

  • [Journal Article] A Toll-like receptor 9-mediated pathway stimulates perilipin 3 (TIP47) expression and induces lipid accumulation in macrophages.2010

    • Author(s)
      Gu JQ, Wang DF, Yan XG, Zhong WL , Zhang J, Fan B, Ikuyama S.
    • Journal Title

      Am J Physiol Endocrinol Meta 299

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Toll-like receptor 9-mediated pathway stimulates perilipin 3 (TIP47) expression and induces lipid accumulation in macrophages.2010

    • Author(s)
      Gu JQ, Wang DF, Yan XG, Zhong WL, Zhang J, Fan B, Ikuyama S.
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oleic acid-induced ADRP expression requires both AP-1 and PPAR-response elements, and is reduced by Pycnogenol through mRNA degradation in NMuLi liver cells.2009

    • Author(s)
      Fan B, Ikuyama S, Gu JQ, Wei P, Oyama J-I, Inoguchi T, Nishimura J.
    • Journal Title

      Am J Physiol EndocrinolMetab 297

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sixty percent of patients with rheumatoid arthritis in Japan have used dietary supplements or health foods.2009

    • Author(s)
      Ikuyama S, Imamura-Takase E, Tokunaga S, Oribe M, Nishimura J.
    • Journal Title

      Modern Rheumatol 19

      Pages: 253-259

    • NAID

      10025112880

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary supplement use in patients with rheumatoid arthritis in Japan.2009

    • Author(s)
      Ikuyama S, Imamura E.
    • Journal Title

      Current Rheumatology Reviews 5

      Pages: 241-245

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pendrin is a novel autoantigen recognized by patients with autoimmune thyroid diseases.2009

    • Author(s)
      Yoshida A, Hisatome I, Taniguchi S, Shirayoshi Y, Yamamoto Y, Miake J, OhkuraT, Akama T, Igawa 0, Shigemasa C, Kamijo K, Ikuyama S, Caturegli P, Suzuki K.
    • Journal Title

      J Clin Endocrinol Metab 94

      Pages: 442-448

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sixty percent of patients with rheumatoid arthritis in Japan have used dietary supplements or health foods2009

    • Author(s)
      Ikuyama S, Imamura-Takase E, Tokunaga S, Oribe M, Nishimura J.
    • Journal Title

      Modern Rheumatol 19

      Pages: 253-259

    • NAID

      10025112880

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oleic acid-induced ADRP expression requires both AP-1 and PPAR-response elements, and is reduced by Pycnogenol through mRNA degradation in NMuLi liver cells2009

    • Author(s)
      Fan B, Ikuyama S, Gu JQ, Wei P, Oyama J-I, Inoguchi T, Nishimura J
    • Journal Title

      Am J Physiol Endocrinol Metab 297

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary supplement use in patients with rheumatoid arthritis in Japan2009

    • Author(s)
      Ikuyama S, Imamura E.
    • Journal Title

      Current Rheumatology Reviews 5

      Pages: 241-245

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] インフリキシマブが奏功したステロイド抵抗性腸管ベーチェット病の1例2009

    • Author(s)
      渡邉秀之, 塩川左斗志, 権藤重喜, 合田英明, 赤木輝久, 西川寛, 本村誠一, 生山祥一郎, 西村純二
    • Journal Title

      九州リウマチ 29

      Pages: 107-112

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sixty percent of patients with rheumatoid arthritis in Japan have used dietary supplements or health foods.2009

    • Author(s)
      Ikuvama S. Imamura-Takase E, Tokunaga S, Oribe M, Nishimura J.
    • Journal Title

      Modern Rheumatol 19

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pendrin is a novel autoantigen recognized by patients with autoimmune thyroid diseases.2009

    • Author(s)
      Yoshida A, Hisatome I, Taniguchi S, Shirayoshi Y, Yamamoto Y, Miake J, Ohkura T, Akama T, Igawa O, Shigemasa C, Kamijo K, Ikuyama S. Caturegli P, Suzuki K.
    • Journal Title

      J Clin Endocrinol Metab 94

      Pages: 442-448

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pycnogenol, an extract from French maritime pine, suppresses Toll-like receptor 4-mediated expression of adipose differentiation-related protein in macrophages.2008

    • Author(s)
      Gu JQ, Ikuyama S, Wei P, Fan B, Oyama J-I, Inoguchi T, Nishimura J.
    • Journal Title

      Am J Physiol Endocrinol Metab 295

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of adipose differentiation-related protein (ADRP) and perilipin in macrophages infected with Mycobacterium leprae.2008

    • Author(s)
      Tanigawa K, Suzuki K, Nakamura K, Akama T, Kawashima A, Wu H, Hayashi M, Takahashi S-I, Ikuyama S, Ito T, Ishii N.
    • Journal Title

      FEMS Microbiol Lett 289

      Pages: 72-79

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pycnogenol, an extract from French maritime pine, suppresses Ton-like receptor 4-mediated expression of adipose differentiation-related protein in macrophages.2008

    • Author(s)
      Gu JQ, Ikuyama S, Wei P, Fan B, Oyama J-I, Inoguchi T, Nishimura J.
    • Journal Title

      Am J Physiol Endocrinol Metab 295

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of adipose differentiation-related protein (ADEP)and perilipin in macrophages infected with Mycobacterium leprae.2008

    • Author(s)
      Tanigawa K, Suzuki K, Nakamura K, Akama T, Kawashima A, Wu H, Hayashi M, Takahashi S-I, Ikuyama S, Ito T, Ishii N.
    • Journal Title

      FEMS Microbiol Lett 289

      Pages: 72-79

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Pycnogenol, an extract from French maritime pine, suppresses osteoclast differentiation.2010

    • Author(s)
      Ikuyama S, Wang Z, Fan B
    • Organizer
      14^<th> International Congress of Endocrinology
    • Place of Presentation
      Kyoto, Japan.
    • Related Report
      2010 Final Research Report
  • [Presentation] Function of adipose differentiation-related protein (ADRP) in myocardial steatosis2010

    • Author(s)
      Suzuki J, Ueno M, Kimura T, Imagawa M, Zenimaru Y, Takahashi S, Ikuyama S, Kraemer FB, Miyamori I
    • Organizer
      14^<th> International Congress of Endocrinology
    • Place of Presentation
      Kyoto, Japan.
    • Related Report
      2010 Final Research Report
  • [Presentation] Pycnogenol, an extract from French maritime pine, suppresses osteoclast differentiation2010

    • Author(s)
      Ikuyama S, Wang Z, Fan B
    • Organizer
      14^<th> International Congress of Endocrinology
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Annual Research Report
  • [Presentation] Function of Adipose Differentiation-Related Protein(ADRP)in Myocardial Steatosis2010

    • Author(s)
      Suzuki J, Ueno M, Kimura T, Imagawa M, Zenimaru Y, Takahashi S, Ikuyama S, Kraemer FB, Miyamori I
    • Organizer
      14^<th> International Congress of Endocrinology
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Annual Research Report
  • [Presentation] ピクノジェノールによる肝細胞の細胞内脂肪滴形成の抑制2009

    • Author(s)
      萢斌、生山祥一郎、谷剣秋、井口登與志、西村純二
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 心筋Adipose differentiation-related protein (ADRP)の機能2009

    • Author(s)
      鈴木仁弥、上野勝巳、木村朋子、今川美智子、銭丸康夫、高橋貞夫、生山祥一郎、宮森勇
    • Organizer
      第52回日本糖尿病学会年次学術集会(プレジデントポスターセッション)
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] ピクノジェノールは肝細胞での細胞内脂肪滴蛋白ADRPの発現を抑制する2009

    • Author(s)
      生山祥一郎、萢斌、西村純二
    • Organizer
      第82回日本内分泌学会学術総会
    • Place of Presentation
      前橋
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 心筋 Adipose differentiation-related protein(ADRP)の機能2009

    • Author(s)
      鈴木仁弥, 上野勝巳, 木村朋子, 今川美智子, 銭丸康夫, 高橋貞夫, 生山祥一郎, 宮森勇
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨関節疾患患者におけるサプリメント利用の実態-薬剤性肝障害を発症した変形性膝関節症(OA)の1例2008

    • Author(s)
      西川寛、生山祥一郎、大庭功一、高瀬恵美子、西村純二
    • Organizer
      第18回日本老年医学会九州地方会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Pycnogenol^R, an extract from the bark of maritime pine, suppresses the expression of Toll-like receptor 4-mediated ADRP expression in macrophages.2008

    • Author(s)
      生山祥一郎, 谷剣秋, 西村純二
    • Organizer
      90th Annual Meeting of The Endocrine Society
    • Place of Presentation
      San Francisco, USA.
    • Related Report
      2010 Final Research Report
  • [Presentation] ピクノジェノールはマクロファージにおけるTLR-4を介する細胞内脂肪滴蛋白ADRPの発現を抑制する2008

    • Author(s)
      生山祥一郎、谷剣秋、西村純二
    • Organizer
      第11回日本補完代替医療学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] ピクノジェノールはマクロファージの細胞内脂肪滴蛋白ADRPの発現を抑制する2008

    • Author(s)
      谷剣秋、生山祥一郎、西村純二
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] ピクノジェノールによるマクロファージの細胞内脂肪滴蛋白ADRPの発現抑制機構2008

    • Author(s)
      生山祥一郎, 谷剣秋, 西村純二
    • Organizer
      第11回日本補完代替医療学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] ハンセン病における細胞内脂質蓄積機構について -らい菌感染マクロファージにおけるADRP, Perilipinの発現誘導-2008

    • Author(s)
      谷川和也, 鈴木幸一, 赤間剛, 川島晃, Huhehasi Wu, 高橋伸一郎, 生山祥一郎, 石井則久
    • Organizer
      第81回日本ハンセン病学会総会・学術大会
    • Place of Presentation
      熊本
    • Related Report
      2008 Annual Research Report
  • [Presentation] らい菌感染マクロファージに発現が変動する様々な分子群2008

    • Author(s)
      谷川和也, 赤間剛, 川島晃, HuhehasiWu, 林もゆる, 関村慎, Pham DangBang, 三島眞代, 石井則久, 生山祥一郎, 武下文彦, 鈴木幸一
    • Organizer
      第49回日本組織細胞化学会総会
    • Place of Presentation
      長崎
    • Related Report
      2008 Annual Research Report
  • [Presentation] Pycnogenol^R, an extract from the bark of maritime pine, suppresses the expression ofToll-like receptor 4-mediated ADRP expression in macrophages.2008

    • Author(s)
      Ikuyama S. Gu J, Nishimura J
    • Organizer
      90th Annual Meeting of The Endocrine Society
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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