| Project/Area Number |
20500620
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
FUKE Yoko Tokyo Metropolitan University, 大学院・人間健康科学研究科ヘルスプロモーションサイエンス学域, 教授 (20073562)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Yoko 首都大学東京, 大学院・人間健康科学研究科ヘルスプロモーションサイエンス学域, 助教 (00240531)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 生活習慣病 / 生活習慣病予防 / 遺伝子多型 / 爪 / DNA / PPARγ / β3-AR / アディポネクチン / 体組成 |
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| Research Abstract |
This study aimed to investigate whether polymorphic variant related obesity are associated with physical characteristics on 40-60 years Japanese women (>BMI25) compared with healthy young women. The allele frequency of Pro12 of PPARγ2 were shown similar result as young women, but genotypic distribution of Trp/Arg on Arg64 of β_3-AR was lower, and G/G276 SNP of adiponectin gene was shown higher than young women. Young women who are normal weight (BMI19.9±1.60) estimating as the high risk of obesity on 3 candidate gene expression were 24%. To recognize own genetic factor participating in obesity at young time may have induced the changes in life-style to control body weight.
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