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The mechanisms of fish oil effects on improvement of glucose and lipid metabolism and fatty liver

Research Project

Project/Area Number 20500626
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionJosai University

Principal Investigator

KASONO Keizo  Josai University, 薬学部・薬学科, 教授 (90177387)

Co-Investigator(Kenkyū-buntansha) 角田 伸代  城西大学, 薬学部, 講師 (60337483)
村木 悦子  城西大学, 薬学部, 助手 (80369157)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords生活習慣病 / 栄養学 / 糖・脂質代謝異常 / 魚油 / 水素添加魚油 / 不飽和脂肪酸 / 抗酸化物質 / 肝臓中脂質 / 脂質代謝 / 糖代謝 / パルミトオレイン酸 / 成分
Research Abstract

(1)Fish oil suppresses weight gain and fat accumulation in the liver on weight rebound.
We investigated the effect of fish oil on weight rebound in KK-Ay mice. The experiments suggest that fish oil suppresses body weight gain and fat accumulation in the liver on the weight rebound phase in mice. Suppression of fat accumulation in the liver is attributed to inhibition of fatty acid synthesis, enhancement of lipolysis and fatty acid oxidation, and normalization of lipoprotein secretion from the liver.
(2)Peroxisome proliferator-activated receptors (PPARs)-independent functions of fish oil on glucose and lipid metabolism in diet-induced obese mice.
The experiments suggest that fish oil decreases lipid levels in plasma and liver via PPARs (PPAR-α and PPAR-γ)pathway-independent mechanism, and that glucose tolerance is inversely regulated by PPARs antagonists under diets containing different oils.
(3)Unsaturated fatty acids in fish oil play a role in adequate fat distribution to plasma, liver an … More d white adipose tissue.
We used hydrogenated fish oil, which has saturated fatty acids with the same carbon chain lengths as the unsaturated fatty acids in fish oil, to clarify the functions of these unsaturated fatty acids on the improvements in lipid and glucose metabolism in mice. Our results indicate that unsaturated fatty acids in the FO diet decrease lipid levels in the liver and maintain the balance of lipid levels in plasma, liver and white adipose tissue. In addition, these results also suggest that C16:1 and C18:1 synthesized in the liver and white adipose tissue may improve glucose tolerance and lipid metabolism in the HFO group.
(4)Regulation of lipid metabolism by palmitoleate and eicosapentaenoic acid (EPA) in mice fed a high-fat diet.
We investigated whether oral administration of palmitoleate improves disorders of lipid and glucose metabolism in mice fed a high-fat diet to clarify the effects of one of the main components of fish oil. This study suggests that orally administered palmitoleate or EPA at relatively low levels improve lipid metabolism impaired with a lard-rich diet. We found that palmitoleate, as a component of fish oil, as well as EPA plays a pivotal role in improving lipid metabolism. Less

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (32 results)

All 2011 2010 2009 2008 Other

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (25 results) Remarks (2 results)

  • [Journal Article] Unsaturated fatty acids in fish oil play a role in adequate fat distribution to plasma, liver and white adipose tissue2011

    • Author(s)
      Sachiko Shiba, Nobuyo Tsunoda, Kanako Ito, Masaki Wakutsu, Etsuko Muraki, Mariko Sonoda, Phyllis. S.Y. Tam, Yoko Fujiwara, Shinji Ikemoto, Keizo Kasono
    • Journal Title

      J.Health Sci. in press

    • NAID

      120005520790

    • Related Report
      2010 Final Research Report
  • [Journal Article] Peroxisome proliferator-activated receptors (PPARs)-independent functions of fish oil on glucose and lipid metabolism in diet-induced obese mice.2010

    • Author(s)
      Masaki Wakutsu, Nobuyo Tsunoda, Sachiko Shiba, Etsuko Muraki, Keizo Kasono
    • Journal Title

      Lipids Health Dis. 9

      Pages: 101-101

    • NAID

      120005518476

    • Related Report
      2010 Final Research Report
  • [Journal Article] Fish oil suppresses weight gain and fat accumulation in the liver on weight rebound in KK-A^y mice2010

    • Author(s)
      Yasuki Mochi, Nobuyo Tsunoda, SachikoShiba, Etsuko Muraki, Keizo Kasono
    • Journal Title

      J.Jpan.Soc.Nutr.Food Sci. 63

      Pages: 69-77

    • NAID

      10026248743

    • Related Report
      2010 Final Research Report
  • [Journal Article] Peroxisome proliferator-activated receptors (PPARs)-independent functions of fish oil on glucose and lipid metabolism in diet-induced obese mice.2010

    • Author(s)
      Wakutsu M, Tsunoda N, Shiba S, Muraki E, Kasono K.
    • Journal Title

      Lipids Health Dis

      Volume: 9(1) Pages: 101-101

    • NAID

      120005518476

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fish oil suppresses weight gain and fat accumulation in the liver on weight rebound in KK-Ay mice.2010

    • Author(s)
      Mochi Y, Tsunoda N, Shiba S, Muraki E, Kasono K.
    • Journal Title

      J Jpn Soc Nutr Food Sci

      Volume: 63(2) Pages: 69-77

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Fish oil diet during the final weight reduction period in weight cycling improves glucose and lipid metabolism.2010

    • Author(s)
      Tsunoda N, Wakutsu M, Muraki E, Kasono K.
    • Organizer
      11th International congress on obesity
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2010-07-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Orally administered physiological dose of palmitoleate improves lipid metabolism in high-fat fed mice.2010

    • Author(s)
      Shiba S, Tsunoda N, Muraki E, Kasono K.
    • Organizer
      11th International congress on obesity
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2010-07-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Orally administered physiological dose of palmitoleate improves lipid metabolism in high-fat fed mice.2010

    • Author(s)
      Shiba S, Tsunoda N, Muraki E, Kasono K
    • Organizer
      11^<th> International congress on obesity
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2010 Final Research Report
  • [Presentation] Fish oil diet during the final weight reduction period in weight cycling improves glucose and lipid metabolism.2010

    • Author(s)
      角田伸代, 和久津昌紀, 村木悦子, 加園恵三
    • Organizer
      11^<th> International congress on obesity
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2010 Final Research Report
  • [Presentation] 魚油に含まれるパルミトオレイン酸の糖・脂質代謝改善作用に対する役割2010

    • Author(s)
      柴祥子, 角田伸代, 村木悦子, 園田麻里子, 譚淑儀, 藤原葉子, 池本真二, 加園恵三
    • Organizer
      第13回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 減量期の魚油摂取におけるウエイトサイクリングへの影響2010

    • Author(s)
      和久津昌紀, 角田伸代, 村木悦子, 加園恵三
    • Organizer
      第13回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Participation of Peroxisome proliferator- activated receptors(PPARs)in glucose and lipid metabolism under fish oil diet2009

    • Author(s)
      和久津昌紀, 角田伸代, 村木悦子, 加園恵三
    • Organizer
      50th International Conference on the Biosciences of Lipids
    • Place of Presentation
      Regensburg Germany
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脂質代謝改善効果に対するペルオキシゾーム増殖剤応答性受容体(PPARs)の影響2009

    • Author(s)
      和久津昌紀, 角田伸代, 村木悦子, 加園恵三
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] What is adequate oil for improvement of lipid and glucose metabolism in the weight loss? Comparison with fish oil and extra virgin olive oil2009

    • Author(s)
      Tsunoda N, Numajiri M, Muraki E, Kasono K
    • Organizer
      50th International Conference on the Biosciences of Lipids
    • Place of Presentation
      Regensburg Germany
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Glucose and lipid metabolism is regulated by not only polyunsaturated fatty acids but also other components in fish oil2009

    • Author(s)
      Shiba S, Tsunoda N, Muraki E, S.Y. TAM P, Sonoda M, Fujiwara Y, Ikemoto S, Kasono K
    • Organizer
      50th International Conference on the Biosciences of Lipids
    • Place of Presentation
      Regensburg Germany
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Participation of Peroxisome proliferator-activated receptors (PPARs) in glucose and lipid metabolism under fish oil diet2009

    • Author(s)
      和久津昌紀, 角田伸代, 村木悦子, 加園恵三
    • Organizer
      50th International Conference on the Biosciences of Lipids
    • Place of Presentation
      Regensburg Germany
    • Related Report
      2010 Final Research Report
  • [Presentation] 水素添加魚油が肝臓及び脂肪組織における脂質代謝とインスリン感受性に与える影響2009

    • Author(s)
      柴祥子, 角田伸代, 譚淑儀, 園田麻里子, 村木悦子, 藤原葉子, 池本真二, 加園恵三
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 魚油の糖・脂質代謝改善効果に対するペルオキシゾーム増殖剤応答性受容体(PPARs)の影響2009

    • Author(s)
      和久津昌紀, 角田伸代, 村木悦子, 加園恵三
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎
    • Related Report
      2010 Final Research Report
  • [Presentation] 魚油の作用に対するPPARsとSREBP1-cの関連性2009

    • Author(s)
      和久津昌紀, 角田伸代, 村木悦子, 加園恵三
    • Organizer
      第12回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 魚摂取または魚油サプリメント摂取が糖・脂質代謝に与える影響の比較検討2009

    • Author(s)
      岡村知広, 青木匡, 吉田明日香, 村木悦子, 角田伸代, 加園恵三
    • Organizer
      第12回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] Fish oil addition or substitution in fat composition of Japanese diet improves lipid metabolism in diabetic KKAy mice2008

    • Author(s)
      Okamura C., Shiba S., Muraki E., Tsunoda N., Kasono K.
    • Organizer
      15th International Congress of Dietetics
    • Place of Presentation
      Yokohama Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] The search for the components in fish oil improving glucose, lipid metabolism and insulin sensitivity in mice2008

    • Author(s)
      Shiba S., Tsunoda N., Phyllis. S.Y. TAM., Sonoda M., Muraki E., Fujiwara Y., Ikemoto S., Kasono K.
    • Organizer
      15th International Congress of Dietetics
    • Place of Presentation
      Yokohama Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Fish oil improves insulin resistance induced by the physical stress in obese KKAy mice2008

    • Author(s)
      Tsunoda N., Hariu K., Seisyu M., Muraki E., Ebata M., Kasono K.
    • Organizer
      16th European Congress on Obesity
    • Place of Presentation
      Geneva Switzerland
    • Related Report
      2010 Final Research Report
  • [Presentation] Dietary fish oil improved glucose and lipid metabolism in diabetic KKAy mice2008

    • Author(s)
      Okamura C., Umezaki T., Muraki E., Ebata M., Tsunoda N., Kasono K.
    • Organizer
      16th European Congress on Obesity
    • Place of Presentation
      Geneva Switzerland
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Search for the components in fish oil improving insulin sensitivity in mice2008

    • Author(s)
      Shiba S., Tsunoda N., Sonoda M., Muraki E., Ikemoto S., Kasono K.
    • Organizer
      16th European Congress on Obesity
    • Place of Presentation
      Geneva Switzerland
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 糖・脂質代謝及びインスリン感受性に影響する魚油成分の検討2008

    • Author(s)
      柴祥子, 角田伸代, 園田麻里子, 村木悦子, 池本真二, 加園恵三
    • Organizer
      第62回日本栄養・食糧学会大会
    • Place of Presentation
      埼玉
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 糖尿病モデルマウスを用いた食事療法に関する研究-食餌中脂肪酸比率の相違における検討-2008

    • Author(s)
      岡村知広, 柴祥子, 村木悦子, 角田伸代, 加園恵三
    • Organizer
      第62回日本栄養・食糧学会大会
    • Place of Presentation
      埼玉
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Fish oil addition or substitution in fat composition of Japanesediet improves lipid metabolism in diabetic KKAy mice.2008

    • Author(s)
      Okamura C., Shiba S., Muraki E., Tsunoda N., Kasono K.
    • Organizer
      15th International Congress of Dietetics
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] The search for the components in fish oil improving glucose, lipid metabolism and insulin sensitivity in mice.2008

    • Author(s)
      Shiba S., Tsunoda N., Phyllis. S. Y. TAM., Sonoda M., Muraki E., Fujiwara Y., Ikemoto S., Kasono K.
    • Organizer
      15th International Congress of Dietetics
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] Fish oil improves insulin resistance induced by the physical stress in obese KKAy mice, 2008. 052008

    • Author(s)
      Tsunoda N., Hariu K., Seisyu M., Muraki E., Ebata M., Kasono K.
    • Organizer
      16th European Congress on Obesity
    • Place of Presentation
      Geneva Switzerland
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks] 城西大学薬学部ホームページ内

    • URL

      http://www.josai.ac.jp/~facpharm/nourish/yv/laboratory_of_nutritional_toxicology.html

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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