| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Research Abstract |
There was no significant difference in body weight and food intake between D group and A group till 52 weeks. GTT at 25 weeks showed that blood glucose at fasting and 30 minutes in D group were significantly increased and insulin level at 30 and 60 minutes were also significantly increased, but not in A group. Hindlimb muscles in D group at 25 weeks showed siginificant decrease of muscle weight and reduction of Akt phosphorylation, but not those in A group. The body weight of D group decreased at 98 weeks, but that of A group was maintained. GTT at 98 weeks showed that the insulin level in A group was maintained, but not in D group.
From these results, Asx supplementation of before onset of type 2 diabetes transiently improves insulin resistance and attenuates atrophy, and that maintains Akt phosphorylation in muscles. Long term Asx supplementation conserved insulin secretory function for OLEF rats.
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