| Project/Area Number |
20500629
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
|
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| Research Institution | Juntendo University |
|---|
Principal Investigator |
SHIMADA Kazunori Juntendo University, 医学部, 准教授 (60327814)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Daichi 順天堂大学, 健康スポーツ科学部, 准教授 (80255653)
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|---|
| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 生活習慣病 / 水中運動 / 動脈硬化 / 免疫応答 |
|---|
| Research Abstract |
Expression of activation markers of dendritic cells (DCs), such as CCL19 and CCR7, were significantly higher in patients with acute coronary syndrome (ACS) than in patients without ACS. Voluntary exercise ameliorated the initiation and progression of atherosclerosis via inhibition of the accumulation of immune cells, such as DCs, macrophages, lymphocytes. In 3D tissue-engineered vessels, wall-embedded DCs responded to lipopolysaccharide, resulting in stimulating autologous CD4 T cells. The levels of CRP and CCL19 were lower in subjects with exercise habits, including water exercise, than those without exercise habits. Therefore, regular exercise, including water exercise, may have anti-inflammatory and immmunomodulating effects.
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