| Project/Area Number |
20500632
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Nihon University |
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Principal Investigator |
IRIBE Yuji Nihon University, 医学部, 研究員 (20348618)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUDA Noboru 日本大学, 大学院・総合科学研究科, 教授 (40267050)
MATSUMOTO Taro 日本大学, 医学部, 教授 (50366580)
NORO Chikako 日本大学, 生産工学部, 准教授 (80311356)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 生活習慣病 / 幹細胞 / 子宮内胎児発育遅延 / メタボリック症候群 / EPC |
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| Research Abstract |
In this study, we have investigated the influence of malnutrition during fetal period on stem cell properties of adulthood. Two models of rat intrauterine growth retardation (IUGR), dexamethasone or rapamycin exposure were analysed for gene expression profile of offspring's bone marrow using microarray technology. As a result, protease gene expression, such as cathepsin K and granzyme B, which are indispensable for bone marrow cell migration, were altered significantly in both of IUGR models in common. This result indicates that malnutrition during fetal period may affect the function of stem cell niche in the adulthood bone marrow.
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