The effect of activity on skeletal muscle and neuromuscular junctions form in rat following temporary denervation.
| Project/Area Number |
20500639
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Chukyo Women's Junior College |
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Principal Investigator |
NISHIZAWA Tomie Chukyo Women's Junior College, 短期大学部, 准教授 (30283980)
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| Co-Investigator(Kenkyū-buntansha) |
KASUGA Norikatu 愛知教育大学, 教育学部, 教授 (60152659)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 筋細胞・組織 / 運動 / 神経筋接合部形態 / ミオシン重鎖mRNA / 神経筋接合部 / 老化 / 自発性走運動 / 筋発揮張力 / 一過性除神経 / 神経筋再接合 / 筋活動量変化 / 骨格筋筋線維タイプ構成比 |
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| Research Abstract |
Our studies so far have reported that the muscle damage causes the temporary denervation. In the regeneration processes of the muscle fiber, the innervation form becomes multiple innervations. Then, it removes the surplus nerve terminals from muscle fiber, and it becomes the single innervation. It is considered that the selection and the elimination of the surplus nerve terminals affect the muscle fiber type. It may be presumed that the activity of the muscle plays pivotal roles in the affects the selection and elimination of the surplus nerve terminals. And it is further estimated that the muscle fiber also has interactive functions and sends signal to the nerve terminal in the process of regeneration. The purpose of this study was to investigate the effect of activity on neuromuscular junction form and Myosin Heavy Chain (MyHC) mRNA expression quantity following temporary denervation in rat skeletal muscle. The values from the group endurance-downhill-endurance training showed the increase from percentage of Type II a fiber and MyHCType I and MyHCType II A of mRNA .And activity following temporary denervation may have a role in the nerve conversion of the neuromuscular junction injury process.
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Report
(4 results)
Research Products
(9 results)
