| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
SNARK (SNF1/AMPK-related kinase)-deficient mice exhibit metabolic disorders. IL-6, which has been reported to regulate whole body energy expenditure, was low in these mice. Voluntary exercise restored serum IL-6 level and ameliorated metabolic disorders. Snark-deficient mice also exhibited increased carcinogen-induced colorectal tumorigenesity. Both administration of recombinant IL-6 and voluntary exercise significantly reduced the tumor susceptibility. These findings imply that the restoration of systemic IL-6 level suppressed the tumorigenesity of Snark-deficient mice and the concomitance of tumorigenesis and systemic metabolic disorders were suggested.
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