Role of dietary protein on the regulation of brain protein synthesis in aged rats
| Project/Area Number |
20500706
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Aichi University of Education |
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Principal Investigator |
HAYASE Kazutoshi Aichi University of Education, 教育学部, 教授 (10144180)
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| Co-Investigator(Renkei-kenkyūsha) |
TUJIOKA Kazuyo 桜花学園大学, 保育学部, 准教授 (90440809)
YOKOGOSHI Hidehiko 静岡県立大学, 食品栄養科学部, 教授 (70109320)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脳タンパク質合成 / タンパク質栄養 / 開始因子 / 成長ホルモン / アミノ酸 / ラット / S6K1 / 4E-BP1 / 脳下垂体摘出 / RNA activity |
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| Research Abstract |
The purpose of present study was to determine the mechanism by which the quality and quantity affect the brain protein synthesis in aged rats. The plasma concentration of growth hormone (GH), the concentration of leucine in the brain, and the phosphorylation of S6K1 and 4E-BP1 in the brains decrined with a decrease of quality and quantity of dietary protein. The protein synthesis rates in the brains of hypophysectomized rats with GH were significantly greater than those in hypophysectomized rats without GH. The results suggest that the GH treatment and the phosphorylation of eukaryotic initiation factors are at least partly related to the brain protein synthesis.
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Report
(4 results)
Research Products
(6 results)
