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Establishment of system to elucidate mechanism for beneficial effect of collagen peptide by ingestion.

Research Project

Project/Area Number 20500712
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionKyoto Prefectural University

Principal Investigator

SATO Kenji  Kyoto Prefectural University, 大学院・生命環境科学研究科, 教授 (00202094)

Co-Investigator(Kenkyū-buntansha) SHIGEMURA Yasutaka  京都府立大学 (20373178)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsコラーゲン / Pro-Hyp / 線維芽細胞 / ペプチド / 皮膚 / トランスポーター / 細胞間マトリッス / PEPT1 / PTH1 / コラーゲンペプチド / Hyp-Gly / 傷修復 / 遊走
Research Abstract

A novel food-derived collagen peptide ; Hyp-Gly was identified in the human peripheral blood. Hyp-Gly stimulated growth of primary cultured fibroblast on collagen gel. The present study also demonstrated that fibroblast migrated from mouse skin expressed peptide transporter 1 and 2 (PEPT1, 2). However, expression of PEPT1, 2 dramatically decreased after several passages. These facts suggest that absorption of the collagen peptide through PEPT1, 2 might play significant role in cell proliferation by collagen peptide.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (40 results)

All 2011 2010 2009 2008 Other

All Journal Article (19 results) (of which Peer Reviewed: 10 results) Presentation (15 results) Book (2 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Identification of a novel food-derived collagen peptide, hydroxyprolyl-glycine, in human peripheral blood by pre-column derivatisation with phenyl isothiocyanate.2011

    • Author(s)
      Shigemura, Y., Akaba, S., Kawashima, E., Park E.-Y. Nakamura, Y., Sato, K.
    • Journal Title

      Food Chemistry In press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a Novel Food-Derived Collagen Peptide, Hydroxyprolyl-Glycine, in Human Peripberal Blood by Pre-column Derivatization with Phenyl Isothiocyanate2011

    • Author(s)
      Shigemura, Y.Akaba, S., Kawashima, E., Park, E.Y., Nakamura, Y., Sato, K.
    • Journal Title

      Food Chemistry

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate.2010

    • Author(s)
      Ichikawa, S., Morifuji, M., Ohara, H., Matsumoto, H., Takeuchi, Y., Sato, K.
    • Journal Title

      Int.J.Food Sci.Nutri. 61

      Pages: 52-60

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] コラーゲンペプチド経口摂取による生理機能とそのメカニズム2010

    • Author(s)
      重村泰毅, 佐藤健司
    • Journal Title

      食品加工技術 30

      Pages: 1-7

    • Related Report
      2010 Final Research Report
  • [Journal Article] アンチエイジングにおける機能性ペプチドの応用2010

    • Author(s)
      佐藤健司
    • Journal Title

      Functional Food 4(1)

      Pages: 67-71

    • Related Report
      2010 Final Research Report
  • [Journal Article] 高付加価値食品開発のための経口摂取により活性を持つペプチドの同定2010

    • Author(s)
      佐藤健司
    • Journal Title

      New Food Industry 52(9)

      Pages: 12-20

    • NAID

      40017275184

    • Related Report
      2010 Final Research Report
  • [Journal Article] Hydroxyproline-Containing Dipeptides and Tripeptides Quantified at High Concentration in Human Blood after Oral Administration of Gelatin Hydrolysate2010

    • Author(s)
      Ichikawa, S., Morifuji, M., Ohara, H., Matsumoto, H., Takeuchi, Y., Sato, K.
    • Journal Title

      Int.J.Food Sci.Nutri.

      Volume: 61 Pages: 52-60

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] コラーゲンペプチド経口摂取による生理機能とそのメカニズム2010

    • Author(s)
      重村泰毅, 佐藤健司
    • Journal Title

      食品加工技術

      Volume: 30 Pages: 1-7

    • Related Report
      2010 Annual Research Report
  • [Journal Article] コラーゲンペプチド経口摂取による生理機能とそのメカニズム2010

    • Author(s)
      重村泰毅
    • Journal Title

      食品加工技術 30

      Pages: 1-7

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Effect of prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin.2009

    • Author(s)
      Shigemura, Y., Iwai, K., Morimatsu, F., Iwamoto, T., Mori, T., Oda, C. Taira, T., Park, E.Y., Nakamura, Y., Sato, K.
    • Journal Title

      J.Agric.Food Chem. 57(2)

      Pages: 444-449

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] コラーゲンペプチドの生理機能2009

    • Author(s)
      佐藤健司
    • Journal Title

      グルコサミン研究 5

      Pages: 79-88

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Hydroxyproline-cntaining dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate2009

    • Author(s)
      Ichikawa, S.
    • Journal Title

      Int.J.Food Sci.Nutri. 61

      Pages: 52-60

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization and comparison of collagens extracted from the digestive tract and skin of a Japanese amber jack (Seriola quinoqeradiata)2009

    • Author(s)
      Nishimoto, M.
    • Journal Title

      J.Food Biochem. 33

      Pages: 777-789

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒトの末梢血中の食事由来コラーゲンペプチドの構造と機能2009

    • Author(s)
      佐藤健司
    • Journal Title

      Food Style 13

      Pages: 51-54

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Effect of prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin.2009

    • Author(s)
      Shigemura, Y.
    • Journal Title

      J.Agric.Food Chem., 57

      Pages: 444-449

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin.2009

    • Author(s)
      Shigemura, Y, 他
    • Journal Title

      J. Agric. Food Chem. 57

      Pages: 444-449

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒト末梢血中の食事由来コラーゲンペプチドの構造と機能2009

    • Author(s)
      佐藤健司
    • Journal Title

      Food Style 13

      Pages: 51-54

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Identification of food-derived bioactive peptides in blood and other biological samples.2008

    • Author(s)
      Sato, K. Iwai, K., Aito-Inoue, M.
    • Journal Title

      J.AOAC Int. 91(4)

      Pages: 995-1001

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] コラーゲンペプチドの経口摂取による生理機能2008

    • Author(s)
      佐藤健司, 他
    • Journal Title

      グルコサミン研究 4

      Pages: 57-62

    • Related Report
      2008 Annual Research Report
  • [Presentation] Impact of extracellular matrix protein hydrolysates on human health.2011

    • Author(s)
      Sato, K.
    • Organizer
      102nd AOCS Annual Meeting & Expo.
    • Place of Presentation
      Cincinnati, USA
    • Year and Date
      2011-05-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Impact of Extracellular Matrix Protein Hydrolysates on Human Health2011

    • Author(s)
      Sato, K
    • Organizer
      American Oil Chemist's Society, Annual Meeting
    • Place of Presentation
      シンシナティ(米国)
    • Year and Date
      2011-05-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification of Food-derived peptides in human peripheral blood-Good candidate for active peptide with health-promotion activity-.2010

    • Author(s)
      Sato, K.
    • Organizer
      PepCon 2010
    • Place of Presentation
      Beijing, Chaina
    • Year and Date
      2010-03-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Identification of Food-Derived Peptides in Human Peripheral Blood-Good Candidate for Active Peptide with Health-Promotion Activity-2010

    • Author(s)
      Sato, K.
    • Organizer
      PepCon 2010
    • Place of Presentation
      Beijing Chaina
    • Related Report
      2009 Annual Research Report
  • [Presentation] Occurrence of Food-Derived Peptides with Biological Activity in Human Blood.2009

    • Author(s)
      Sato, K.
    • Organizer
      Annual Meeting of International Society for Neutraceuticals and Functional Foods
    • Place of Presentation
      San Francisco
    • Year and Date
      2009-11-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Occurrence of Food-Derived Peptides with Biological Activity in Human Blood.2009

    • Author(s)
      Sato, K.
    • Organizer
      3rd International Congress on Food and Nutrition
    • Place of Presentation
      Antalya Turkey
    • Year and Date
      2009-04-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Occurrence of food-derived peptides with biological. activity in human blood2009

    • Author(s)
      Sato, K.
    • Organizer
      International Congress on Food and Nutrition
    • Place of Presentation
      Antalya Turkey
    • Year and Date
      2009-04-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of Prolyl-Hydroxyproline (Pro-Hyp) on proliferation of skin fibroblasts : A possible mechanism for improvement of skin condition by collagen peptide ingestion2009

    • Author(s)
      Shigemura Y ら
    • Organizer
      American Chemical Society
    • Place of Presentation
      Salt Lake City, USA
    • Year and Date
      2009-03-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Biological Activity of Food-Derived Peptides in Human Blood2009

    • Author(s)
      Sato, K.
    • Organizer
      International Society for Neutraceuticals and Functional Foods
    • Place of Presentation
      San Francisco, CA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Occurrence of Food-Derived Peptides with Biological Activity in Human Blood2009

    • Author(s)
      Sato, K.
    • Organizer
      3rd International Congress on Food and Nutrition
    • Place of Presentation
      Antalya, Turkey
    • Related Report
      2009 Annual Research Report
  • [Presentation] Growth enhancement of skin fibroblast by food-derived collagen peptide in human blood2008

    • Author(s)
      Shigemura Y. ら
    • Organizer
      International Society for Nutraceuticals and Functional Foods
    • Place of Presentation
      Taichung, Taiwan
    • Year and Date
      2008-11-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 食事由来主要コラーゲンペプチド(Pro-Hyp, Hyp-Gly)がマウス皮膚線維芽細胞増殖におよぼす影響2008

    • Author(s)
      重村泰毅ら
    • Organizer
      日本農芸化学会
    • Place of Presentation
      亀岡市
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] コラーゲンペプチドを摂取したヒト末梢血中のコラーゲンペプチド構造の個人差2008

    • Author(s)
      佐藤健司ら
    • Organizer
      日本農芸化学会
    • Place of Presentation
      亀岡市
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Subject to subject change in composition of food-derived collagen peptides in human peripheral blood after ingestion of enzymatic digest of gelatin.2008

    • Author(s)
      Sato, K.
    • Organizer
      Institute of Food Technologist Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2008-07-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Subject to subject change in composition of food-derived collagen peptides in human peripheral blood after ingestion of enzymatic digest of gelatin2008

    • Author(s)
      Sato, K. ら
    • Organizer
      Institute of Food Technologist
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2008-06-30
    • Related Report
      2008 Annual Research Report
  • [Book] Marine Cosmeceuticals : Latest Trends and Prospects2011

    • Author(s)
      Sato, K., Shigemura, Y.
    • Publisher
      CRC Press(印刷中)
    • Related Report
      2010 Annual Research Report
  • [Book] Marine Cosmeceuticals : Latest Trends and Prospects, 共著

    • Author(s)
      ato, K., Shigemura, Y.
    • Publisher
      CRC Press 印刷中
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.senryaku-kyoto.jp/contents/search/index.php?mode=show&seq=1165

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.senryaku-kyoto.jp/contents/search/index.php?mode=show&seq=1165

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://cocktail.kpu.ac.jp/shomuka/gakujyutsu/database_index.html

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 創傷治療用医薬組成物2009

    • Inventor(s)
      佐藤健司ら
    • Industrial Property Rights Holder
      チッソ株式会社
    • Industrial Property Number
      2009-042671
    • Filing Date
      2009-02-25
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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