Study for the development of a novel treatment to prevent atherosclerosis with guava tea
| Project/Area Number |
20500713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Okayama Prefectural University |
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Principal Investigator |
TAKAHASHI Yoshitaka Okayama Prefectural University, 保健福祉学部, 教授 (10236333)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAKAMI Yuki 岡山県立大学, 保健福祉学部, 助教 (30453202)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 12-リポキシゲナーゼ / アラキドン酸 / 酸化LDL / 動脈硬化 / グアバポリフェノール / グアバ葉 / 12/15-リポキシゲナーゼ / 12 / 15-リポキシゲナーゼ / グアバ茶 / ケルセチン |
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| Research Abstract |
Oxidative modification of low density lipoprotein (LDL) is one of the critical steps for the development of atherosclerosis and leukocyte-type 12-lipoxygenase has been suggested to play an essential role in this process. In this study, we demonstrated that guava leaf extracts inhibited not only the leukocyte-type 12-lipoxygenase activity but also LDL oxidation mediated by the enzyme-overexpressing J774A.1 cells. Oral administration of guava leaf extracts to apo E-knockout mice significantly reduced the area of atherogenic lesions developed in the aorta and aortic sinus. The major components inhibiting leukocyte-type 12-lipoxygenase contained in guava leaf extracts were identified as ethyl gallate and quercetin.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Gastrointestinal Digestion and Absorption of Pen j 1, a Major Allergen from Kuruma Prawn, Penaeus japonicas.2011
Author(s)
Kunimoto A, Yokoro M, Murota K, Yamanishi R, Suzuki-Yamamoto T, Suzuki M, Yutani C, Doi S, Hiemori M, Yamashita H, Takahashi Y, Tsuji H, Kimoto M.
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Journal Title
Biosci. Biotechnol. Biochem in press
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[Journal Article] Functional expression of single-chain antibody to leukotriene C(4)2010
Author(s)
Kawakami Y, Yamashita C, Kashiwase Y, Morinaka T, Suzuki-Yamamoto T, Yamashita H, Kimoto M, Tsuji H, Kurahashi Y, Daiyasu H, Toh H, Sugahara M, Miyano M, Yamamoto S, Takahashi Y.
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Journal Title
Biochem Biophys Res Commun 392
Pages: 421-425
Related Report
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[Journal Article] Tumor-suppressive lipoxygenases inhibit the expression of c-myc mRNA coding region determinant-binding protein/insulin-like growth factor II mRNA-binding protein 1 in human prostate carcinoma PC-3 cells.2009
Author(s)
Kawakami Y, Kubota N, Ekuni N, Suzuki-Yamamoto T, Kimoto M, Yamashita H, Tsuji H, Yoshimoto T, Jisaka M, Tanaka J, Fujimura HF, Miwa Y, Takahashi Y.
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Journal Title
Biosci. Biotechnol. Biochem 73
Pages: 1811-1817
NAID
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[Journal Article] Effects of acetate on lipid metabolism in muscles and adipose tissues of type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats2009
Author(s)
Yamashita H, Maruta H, Jozuka M, Kimura R, Iwabuchi H, Yamato M, Saito T, Fujisawa K, Takahashi Y, Kimoto M, Hiemori M, Tsuji H.
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Journal Title
Biosci Biotechnol Biochem 73
Pages: 570-576
NAID
Related Report
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