Analysis of induction mechanism of hypoadiponectinemia by trans-fatty acids.

Research Project

Project/Area Number	20500719
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Eating habits, studies on eating habits
Research Institution	Seitoku University
Principal Investigator	KNOU Kazutaka Seitoku University, 人間栄養学部, 教授 (70111507)
Co-Investigator(Kenkyū-buntansha)	KUBO Hirotaka 聖徳大学, 人文学部, 教授 (70119791)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	脂肪酸 / アディポネクチン / 培養細胞 / PCR / トランス脂肪酸 / PPAR
Research Abstract	Trans-fatty acids may cause atherosclerosis and ischemic heart disease. The governments of Western countries have begun efforts to reduce intake. Analysis of the mechanisms causing these disorders has not been done, however. In this study, we analyze the effects of elaidic acid and found that a cascade involving elaidic acid→TLR4→activation of NF-kB→ TNF-α→secretion→autocrine/paracrine→PPAR-αexpression resulted a decrease of adiponectin production.

Report

(4 results)