Analysis of induction mechanism of hypoadiponectinemia by trans-fatty acids.
| Project/Area Number |
20500719
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Seitoku University |
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Principal Investigator |
KNOU Kazutaka Seitoku University, 人間栄養学部, 教授 (70111507)
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| Co-Investigator(Kenkyū-buntansha) |
KUBO Hirotaka 聖徳大学, 人文学部, 教授 (70119791)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脂肪酸 / アディポネクチン / 培養細胞 / PCR / トランス脂肪酸 / PPAR |
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| Research Abstract |
Trans-fatty acids may cause atherosclerosis and ischemic heart disease. The governments of Western countries have begun efforts to reduce intake. Analysis of the mechanisms causing these disorders has not been done, however. In this study, we analyze the effects of elaidic acid and found that a cascade involving elaidic acid→TLR4→activation of NF-kB→ TNF-α→secretion→autocrine/paracrine→PPAR-αexpression resulted a decrease of adiponectin production.
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Report
(4 results)
Research Products
(4 results)
