Estimation of animal experiment models to evaluate the early inflammation stage in adipocytes following obesity and investigation of anti-inflammatory factors in foods
| Project/Area Number |
20500720
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Otsuma Women's University |
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Principal Investigator |
AOE Seiichiro 大妻女子大学, 家政学部, 教授 (90365049)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 栄養学 / 肥満 / 脂肪細胞 / 炎症 / 動物実験 / C57BL/6Jマウス / 初期炎症 / NADPHオキシダーゼ / NOxサブユニット / 卵巣摘出マウス / KK/Taマウス / カルシウム / 大麦 / 食と栄養 / 炎症性マーカー / マクロファージ / F4/80 / MCP-1 / IL-6 / 脂肪組織 / C57BL / 6Jマウス / F4 / 80 / 免疫染色 / DIOマウス / KK / Taマウス / アデイポサイトカイン / C-反応性タンパク質 |
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| Research Abstract |
We investigated the influences of high fat or low fat diet and feeding periods on the mRNA expressions of adipocyte inflammatory parameters in C57BL/6J, KK/Ta, B6db/+(leptin receptor deficient hetero type) mice. Our results indicated that significant increase in abdominal fat mass and mRNA expressions of inflammatory parameters were observed after 4 weeks feeding of the high fat diet. On the short term feeding, detectable inflammatory parameters were NADPH oxidase subunits, MCP-1, IL-6, resistin. Impaired glucose tolerance and adipocyte enlargement were observed on the 8 or 12 weeks feeding. Using these parameters, anti-inflammatory effects of barley and dairy calcium were observed.
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Report
(6 results)
Research Products
(21 results)
