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Effect of hydrogen on prevention and improvement of diabetes

Research Project

Project/Area Number 20500723
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionNippon Medical School

Principal Investigator

KAMIMURA Naomi  Nippon Medical School, 老人病研究所, 講師 (60283800)

Co-Investigator(Renkei-kenkyūsha) OHSAWA Ikuroh  東京都健康長寿医療センター研究所, 老化制御研究チーム, 研究副部長 (30343586)
OHTA Shigeo  日本医科大学, 医学研究科, 教授 (00125832)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords糖尿病 / 酸化ストレス / 抗酸化剤
Research Abstract

Oxidative stress is one of the causes of diabetes. While some ROS (reactive oxygen species) such as NO play physiological roles. Thus, cytotoxic radicals such as ?OH must be neutralized without compromising the essential biological activities of physiologically beneficial ROS. In this study we showed that consumption of molecular hydrogen markedly reduces hepatic oxidative stress levels and improves hyperglycemia and obesity in diabetes model mice.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (34 results)

All 2011 2010 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (19 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice.2011

    • Author(s)
      Kamimura N., Nishimaki K., Ohsawa I., Ohta, S.
    • Journal Title

      Obesity (Epub ahead of print)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice2011

    • Author(s)
      Naomi Kamimura
    • Journal Title

      Obesity

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardioprotective effect of intermittent fasting is associated with an elevation of adiponectin levels in rats.2010

    • Author(s)
      Wan R., Ahmet I., Brown M., Cheng A., Kamimura N., Talan M., Mattson M.P.
    • Journal Title

      J.Nutr.Biochem. 21

      Pages: 413-417

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cardioprotective effect of intermittent fasting is associated with an elevation of adiponectin levels in rats.2010

    • Author(s)
      Wan R
    • Journal Title

      J Nutr Biochem. 21

      Pages: 413-417

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice.2009

    • Author(s)
      Nakashima-Kamimura N., Mori T., Ohsawa I., Asoh S., Ohta S.
    • Journal Title

      Cancer Chemother Pharmacol. 64

      Pages: 753-761

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice.2009

    • Author(s)
      Nagata K., Nakashima-Kamimura N., Mikami T., Ohsawa I., Ohta S.
    • Journal Title

      Neuropsychopharmacology. 34

      Pages: 501-508

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice.2009

    • Author(s)
      Nakashima-Kamimura N
    • Journal Title

      Cancer Chemother Pharmacol. 64

      Pages: 753-761

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice.2009

    • Author(s)
      Nakashima-Kamimura N, et al.
    • Journal Title

      Cancer Chemother Phrmacol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice.2009

    • Author(s)
      Nagata K, et al.
    • Journal Title

      Neuropsychopharmacology 34

      Pages: 501-508

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of chemotherapy-induced alopecia by the anti-death FNK protein.2008

    • Author(s)
      Nakashima-Kamimura N., Nishimaki K., Mori T., Asoh S., Ohta S.
    • Journal Title

      Life Sci. 82

      Pages: 218-225

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of chemotherapy-induced alopecia by the anti-death FNK protein.2008

    • Author(s)
      Nakashima-Kamimura N, et al.
    • Journal Title

      Life Sci. 82

      Pages: 218-225

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肝臓における水素分子の動態とその効果2011

    • Author(s)
      上村尚美
    • Organizer
      分子状水素医学シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2011-02-18
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Molecular hydrogen improves obesity and diabetes by inducing FGF21 through reducing oxidative stress in db/db mice.2010

    • Author(s)
      Naomi Kamimura
    • Organizer
      7th ASMRM (Asian symposium of Mitochondrial Research and Medicine) and 10th J-mit (Japanese Mitochondrial Research and Medicine)
    • Place of Presentation
      Fukuoka
    • Year and Date
      2010-12-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 水素分子は、肝臓グリコーゲン中に蓄積し、糖尿病モデルマウスの症状を改善する2010

    • Author(s)
      上村尚美
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Molecular hydrogen improves obesity and diabetes by inducing FGF21 through reducing oxidative stress in db/db mice.2010

    • Author(s)
      上村尚美
    • Organizer
      7th ASMRM & 10th J-mit
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2010-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規細胞死抑制タンパク質を用いたミトコンドリア機能保護というまったく新しいアプローチによる精子保存技術の開発2010

    • Author(s)
      西園啓文
    • Organizer
      第103回 日本繁殖生物学会大会
    • Place of Presentation
      青森
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規細胞死抑制タンパク質を用いたミトコンドリア機能保護というまったく新しいアプローチによる精子保存技術の開発2010

    • Author(s)
      西園啓文
    • Organizer
      第103回日本繁殖生物学会大会
    • Place of Presentation
      青森
    • Year and Date
      2010-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 細胞導入型細胞死抑制タンンパク質PTD-FNKによる精子凍結保存2010

    • Author(s)
      佐藤佑一朗
    • Organizer
      第19回日本Cell Death学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-07-31
    • Related Report
      2010 Final Research Report
  • [Presentation] 細胞導入型細胞死抑制タンパク質PTD-FNKによる精子凍結保存2010

    • Author(s)
      佐藤佑一朗
    • Organizer
      第19回 日本Cell Death学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-07-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖尿病モデルマウスの症状改善に対する水素分子の効果2009

    • Author(s)
      上村尚美
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖尿病モデルマウスの症状改善に対する水素分子の効果2009

    • Author(s)
      上村尚美
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 水素分子による軟骨組織の酸化ストレス傷害の軽減2009

    • Author(s)
      花岡央泰
    • Organizer
      第24回日本整形外科学会基礎学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-11-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 水素分子摂取による身体拘束マウスの海馬依存的学習・記憶能力低下の抑制2008

    • Author(s)
      永田和史
    • Organizer
      第8回日本ミトコンドリア学会年会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-18
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 水素分子は抗癌剤シスプラチンの抗腫瘍効果を抑制することなく副作用である腎障害を軽減する2008

    • Author(s)
      上村尚美
    • Organizer
      第31回日本分子生物学会/第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 抗癌剤シスプラチンに誘導される腎臓でのアポトーシスは水素分子により抑制される2008

    • Author(s)
      上村尚美
    • Organizer
      第17回日本アポトーシス研究会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-08-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Three-dimensional analysis of mitochondrial structure in a HeLa cell by Ultra-High Voltage Electron Microscope.2008

    • Author(s)
      上村尚美
    • Organizer
      Euromit 7/The seventh European Meeting on Mitochondrial Pathology
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2008-06-11
    • Related Report
      2010 Final Research Report
  • [Presentation] Three-dimensional analysis of mitochondrial structure in a HeLa cell by Ultra-High Voltage Electron Microscope.2008

    • Author(s)
      Kamimura, N., et al.
    • Organizer
      The_seventh European Meeting on Mitochondrial Pathology
    • Place of Presentation
      Stockholm Sweden
    • Related Report
      2008 Annual Research Report
  • [Presentation] Hydrogen acts as a therapeutic and preventive antioxidant.2008

    • Author(s)
      Ohta, S., et al.
    • Organizer
      The_seventh European Meeting on Mitochondrial Pathology
    • Place of Presentation
      Stockholm Sweden
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗癌剤シスプラチンにツ誘導される腎臓でのアポトーシスは水素分子により抑制される.2008

    • Author(s)
      上村尚美, 他
    • Organizer
      第17回日本アポトーシス研究会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 水素分子は抗癌剤シスプラチンの抗腫瘍効果を抑制することなく副作用である腎障害を軽減する.2008

    • Author(s)
      上村尚美, 他
    • Organizer
      BMB2008第31回日本分子生物学会/第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://home.nms.ac.jp/ig/saiboseibutsu/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.ig.nms.ac.jp/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.ig.nms.ac.jp/

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞死抑制活性強化タンパク質FNKを用いた脱毛の防止2011

    • Inventor(s)
      太田成男、上村尚美、麻生定光
    • Industrial Property Rights Holder
      日本医科大学
    • Filing Date
      2011-02-25
    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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