Effect of hydrogen on prevention and improvement of diabetes
| Project/Area Number |
20500723
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nippon Medical School |
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Principal Investigator |
KAMIMURA Naomi Nippon Medical School, 老人病研究所, 講師 (60283800)
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| Co-Investigator(Renkei-kenkyūsha) |
OHSAWA Ikuroh 東京都健康長寿医療センター研究所, 老化制御研究チーム, 研究副部長 (30343586)
OHTA Shigeo 日本医科大学, 医学研究科, 教授 (00125832)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 糖尿病 / 酸化ストレス / 抗酸化剤 |
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| Research Abstract |
Oxidative stress is one of the causes of diabetes. While some ROS (reactive oxygen species) such as NO play physiological roles. Thus, cytotoxic radicals such as ?OH must be neutralized without compromising the essential biological activities of physiologically beneficial ROS. In this study we showed that consumption of molecular hydrogen markedly reduces hepatic oxidative stress levels and improves hyperglycemia and obesity in diabetes model mice.
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Report
(4 results)
Research Products
(34 results)
