Effect of hydrogen on prevention and improvement of diabetes

• Project/Area Number: 20500723
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Nippon Medical School
• Principal Investigator: KAMIMURA Naomi Nippon Medical School, 老人病研究所, 講師 (60283800)
• Co-Investigator(Renkei-kenkyūsha): OHSAWA Ikuroh 東京都健康長寿医療センター研究所, 老化制御研究チーム, 研究副部長 (30343586) ; OHTA Shigeo 日本医科大学, 医学研究科, 教授 (00125832)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 糖尿病 / 酸化ストレス / 抗酸化剤

Research Abstract

Oxidative stress is one of the causes of diabetes. While some ROS (reactive oxygen species) such as NO play physiological roles. Thus, cytotoxic radicals such as ?OH must be neutralized without compromising the essential biological activities of physiologically beneficial ROS. In this study we showed that consumption of molecular hydrogen markedly reduces hepatic oxidative stress levels and improves hyperglycemia and obesity in diabetes model mice.

Research Products

• [Journal Article] Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. (2011)
  • Author(s): Kamimura N., Nishimaki K., Ohsawa I., Ohta, S.
  • Journal Title: Obesity (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice (2011)
  • Author(s): Naomi Kamimura
  • Journal Title: Obesity Volume: (in press)
  • Peer Reviewed
• [Journal Article] Cardioprotective effect of intermittent fasting is associated with an elevation of adiponectin levels in rats. (2010)
  • Author(s): Wan R., Ahmet I., Brown M., Cheng A., Kamimura N., Talan M., Mattson M.P.
  • Journal Title: J.Nutr.Biochem. 21 Pages: 413-417
  • Peer Reviewed
• [Journal Article] Cardioprotective effect of intermittent fasting is associated with an elevation of adiponectin levels in rats. (2010)
  • Author(s): Wan R
  • Journal Title: J Nutr Biochem. 21 Pages: 413-417
  • Peer Reviewed
• [Journal Article] Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. (2009)
  • Author(s): Nakashima-Kamimura N., Mori T., Ohsawa I., Asoh S., Ohta S.
  • Journal Title: Cancer Chemother Pharmacol. 64 Pages: 753-761
  • Peer Reviewed
• [Journal Article] Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. (2009)
  • Author(s): Nagata K., Nakashima-Kamimura N., Mikami T., Ohsawa I., Ohta S.
  • Journal Title: Neuropsychopharmacology. 34 Pages: 501-508
  • Peer Reviewed
• [Journal Article] Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. (2009)
  • Author(s): Nakashima-Kamimura N
  • Journal Title: Cancer Chemother Pharmacol. 64 Pages: 753-761
  • Peer Reviewed
• [Journal Article] Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. (2009)
  • Author(s): Nakashima-Kamimura N, et al.
  • Journal Title: Cancer Chemother Phrmacol. (in press)
  • Peer Reviewed
• [Journal Article] Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. (2009)
  • Author(s): Nagata K, et al.
  • Journal Title: Neuropsychopharmacology 34 Pages: 501-508
  • Peer Reviewed
• [Journal Article] Prevention of chemotherapy-induced alopecia by the anti-death FNK protein. (2008)
  • Author(s): Nakashima-Kamimura N., Nishimaki K., Mori T., Asoh S., Ohta S.
  • Journal Title: Life Sci. 82 Pages: 218-225
  • Peer Reviewed
• [Journal Article] Prevention of chemotherapy-induced alopecia by the anti-death FNK protein. (2008)
  • Author(s): Nakashima-Kamimura N, et al.
  • Journal Title: Life Sci. 82 Pages: 218-225
  • Peer Reviewed
• [Presentation] 肝臓における水素分子の動態とその効果 (2011)
  • Author(s): 上村尚美
  • Organizer: 分子状水素医学シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2011-02-18
• [Presentation] Molecular hydrogen improves obesity and diabetes by inducing FGF21 through reducing oxidative stress in db/db mice. (2010)
  • Author(s): Naomi Kamimura
  • Organizer: 7th ASMRM (Asian symposium of Mitochondrial Research and Medicine) and 10th J-mit (Japanese Mitochondrial Research and Medicine)
  • Place of Presentation: Fukuoka
  • Year and Date: 2010-12-16
• [Presentation] 水素分子は、肝臓グリコーゲン中に蓄積し、糖尿病モデルマウスの症状を改善する (2010)
  • Author(s): 上村尚美
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] Molecular hydrogen improves obesity and diabetes by inducing FGF21 through reducing oxidative stress in db/db mice. (2010)
  • Author(s): 上村尚美
  • Organizer: 7th ASMRM & 10th J-mit
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2010-11-16
• [Presentation] 新規細胞死抑制タンパク質を用いたミトコンドリア機能保護というまったく新しいアプローチによる精子保存技術の開発 (2010)
  • Author(s): 西園啓文
  • Organizer: 第103回 日本繁殖生物学会大会
  • Place of Presentation: 青森
  • Year and Date: 2010-09-04
• [Presentation] 新規細胞死抑制タンパク質を用いたミトコンドリア機能保護というまったく新しいアプローチによる精子保存技術の開発 (2010)
  • Author(s): 西園啓文
  • Organizer: 第103回日本繁殖生物学会大会
  • Place of Presentation: 青森
  • Year and Date: 2010-09-02
• [Presentation] 細胞導入型細胞死抑制タンンパク質PTD-FNKによる精子凍結保存 (2010)
  • Author(s): 佐藤佑一朗
  • Organizer: 第19回日本Cell Death学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-07-31
• [Presentation] 細胞導入型細胞死抑制タンパク質PTD-FNKによる精子凍結保存 (2010)
  • Author(s): 佐藤佑一朗
  • Organizer: 第19回 日本Cell Death学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-07-31
• [Presentation] 糖尿病モデルマウスの症状改善に対する水素分子の効果 (2009)
  • Author(s): 上村尚美
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-11
• [Presentation] 糖尿病モデルマウスの症状改善に対する水素分子の効果 (2009)
  • Author(s): 上村尚美
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-11
• [Presentation] 水素分子による軟骨組織の酸化ストレス傷害の軽減 (2009)
  • Author(s): 花岡央泰
  • Organizer: 第24回日本整形外科学会基礎学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2009-11-06
• [Presentation] 水素分子摂取による身体拘束マウスの海馬依存的学習・記憶能力低下の抑制 (2008)
  • Author(s): 永田和史
  • Organizer: 第8回日本ミトコンドリア学会年会
  • Place of Presentation: 東京
  • Year and Date: 2008-12-18
• [Presentation] 水素分子は抗癌剤シスプラチンの抗腫瘍効果を抑制することなく副作用である腎障害を軽減する (2008)
  • Author(s): 上村尚美
  • Organizer: 第31回日本分子生物学会/第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] 抗癌剤シスプラチンに誘導される腎臓でのアポトーシスは水素分子により抑制される (2008)
  • Author(s): 上村尚美
  • Organizer: 第17回日本アポトーシス研究会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-08-01
• [Presentation] Three-dimensional analysis of mitochondrial structure in a HeLa cell by Ultra-High Voltage Electron Microscope. (2008)
  • Author(s): 上村尚美
  • Organizer: Euromit 7/The seventh European Meeting on Mitochondrial Pathology
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2008-06-11
• [Presentation] Three-dimensional analysis of mitochondrial structure in a HeLa cell by Ultra-High Voltage Electron Microscope. (2008)
  • Author(s): Kamimura, N., et al.
  • Organizer: The_seventh European Meeting on Mitochondrial Pathology
  • Place of Presentation: Stockholm Sweden
• [Presentation] Hydrogen acts as a therapeutic and preventive antioxidant. (2008)
  • Author(s): Ohta, S., et al.
  • Organizer: The_seventh European Meeting on Mitochondrial Pathology
  • Place of Presentation: Stockholm Sweden
• [Presentation] 抗癌剤シスプラチンにツ誘導される腎臓でのアポトーシスは水素分子により抑制される. (2008)
  • Author(s): 上村尚美, 他
  • Organizer: 第17回日本アポトーシス研究会
  • Place of Presentation: 京都
• [Presentation] 水素分子は抗癌剤シスプラチンの抗腫瘍効果を抑制することなく副作用である腎障害を軽減する. (2008)
  • Author(s): 上村尚美, 他
  • Organizer: BMB2008第31回日本分子生物学会/第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Remarks]
  • URL: http://home.nms.ac.jp/ig/saiboseibutsu/index.html
• [Remarks]
  • URL: http://www.ig.nms.ac.jp/
• [Remarks]
  • URL: http://www.ig.nms.ac.jp/
• [Patent(Industrial Property Rights)] 細胞死抑制活性強化タンパク質FNKを用いた脱毛の防止 (2011)
  • Inventor(s): 太田成男、上村尚美、麻生定光
  • Industrial Property Rights Holder: 日本医科大学
  • Filing Date: 2011-02-25