| Project/Area Number |
20500726
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kanagawa Institute of Technology |
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Principal Investigator |
KIYOSE Chikako Kanagawa Institute of Technology, 応用バイオ科学部, 教授 (50272745)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ビタミン / 栄養学 / 食品機能 / 生体機能利用 / バイオテクノロジー / ビタミンE / トコトリエノール / プロドラッグ作用 / ナトリウム排泄 / γ-トコトリエノール / γ-トコトフェロール / γ-CEHC / CEHC定量法 / 高食塩食摂取 / 尿中ナトリウム排泄量 / ビタミンE体内代謝物 / CEHC / ECD-HPLC法 |
|---|
| Research Abstract |
It is knouwn thatγ-Tocopherol and γ-tocotrienol, one of the vitamin E analogs, are metabolized to γ-carboxyethyle-hydoroxychroman (γ-CEHC) in vivo. On the other hands, γ-CEHC has the physiological activity for sodium excretion into rat urine. Then, this study was further investigated on the pro-drug action and the production of γ-CEHC fromγ-tocopherol and γ-tocotrienol in vivo. Consequently, it is clear that γ-tocotrienol is metabolized to γ-CEHC more than γ-tocopherol. Moreover, it is suggested that it may exist the functional domain on the pro-drug action of vitamin E analogs.
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