| Project/Area Number |
20500733
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
|
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| Research Institution | Matsuyama University |
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Principal Investigator |
AMAKURA Yoshiaki Matsuyama University, 薬学部, 准教授 (50321857)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 健康と食生活 / アリル炭化水素受容体 / 機能性食品 / 食の安全 / 食の安全性評価 / ダイオキシン / レポータージーンアッセイ |
|---|
| Research Abstract |
The aryl hydrocarbon receptor (AhR) mediates the toxic and biological actions of dioxins. We previously demonstrated that several natural aryl hydrocarbon receptor ligands from foods showed a dioxin-like activity at high concentration levels. In this study, to pursue the possible use as a probe for estimating the safety of functional foods, which predicts an excess intake of food constituents, the influence of health food materials on the AhR was evaluated. As a result, most tested samples did not show any AhR activation at high concentration levels, but some samples promoted the AhR activity in the range of high concentration levels at 10^6-10^9-fold compared to that of dioxin. Furthermore, several new natural AhR ligands were characterized from the AhR activated fractions of health food materials.
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